Abstract：
:The biological activities of garlic may be affected by different processing methods. This study, therefore, aimed to evaluate potential anticancer effects of different type of processed garlic extracts on WEHI-164 tumor cells in inbred BALB/c mice and correlate the tumor growth rates with some garlic constituents. In a preclinical trial 60 BALB/c mice were injected with WEHI-164 tumor cells and divided into six groups of 10 animals. Group 1 mice received 200 μL of saline, and groups 2-6 were injected intraperitoneally with fresh, microwaved, 3-month-old, leaves, and boiled garlic extracts, respectively, at 20 mg/kg/0.2 mL. Three weeks following tumor inoculation, the mean tumor size in garlic extract-treated groups was reduced with significant reductions observed in the fresh and microwaved extract groups compared with the control group (P<.05). The antioxidant capacity and the amounts of allicin, flavonoids, and phenolic compounds in differentially processed garlic were evaluated and correlated with their anticancer activities. There was a linear correlation between the amounts of allicin, flavonoids, or phenolic components derived from fresh, microwaved, 3-month-old, leaves, and boiled garlic and cancer growth prevention. In conclusion, garlic has anticancer activity against WEHI-164 tumor cells, and processing such as heating reduces its effect dramatically. The anticancer activities of different kinds of garlic are related to the level of allicin, flavonoids, and phenolic components. Therefore, fresh garlic has the highest content of bioactive components and the greatest anticancer efficacy.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Shirzad H,Taji F,Rafieian-Kopaei Mdoi
10.1089/jmf.2011.1594subject
Has Abstractpub_date
2011-09-01 00:00:00pages
969-74issue
9eissn
1096-620Xissn
1557-7600journal_volume
14pub_type
杂志文章abstract：:cis-Diamminedichloroplatinum (II) (cisplatin) is an effective chemotherapeutic agent successfully used in the treatment of a wide range of tumors. Nevertheless, nephrotoxicity has restricted its clinical use. The use of more than a few antioxidants has shown that reactive oxygen species are involved in cisplatin-induc...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.0033
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abstract：:Tagatose, a low-calorie, full-bulk natural sugar, has just attained GRAS (Generally Recognized As Safe) status under U.S. Food and Drug Administration (FDA) regulations, thereby permitting its use as a sweetener in foods and beverages. This paper presents all current aspects of tagatose with respect to demonstrated fo...
journal_title：Journal of medicinal food
pub_type： 杂志文章,评审
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journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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abstract：:Many studies have focused on the effect of fresh fruits on the risk of developing cancer and other diseases involved with reactive species and free radicals. The intake of frozen fruits has spread widely in the last years, but, until now, their biological activity is not completely known. In this study, 23 samples of ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
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abstract：:Phenethyl isothiocyanate (PITC) is the hydrolysis product of the glucosinolate gluconasturtiin in cruciferous vegetables. This study was conducted to determine whether PITC inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in the mouse ear. Topical application of 5 nmol of TPA to mouse ears mark...
journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2018.4289
更新日期：2019-05-01 00:00:00
abstract：:Telfairia occidentalis (Cucurbitaceae) is a leafy vegetable used in soup and folk medicine in southern Nigeria. Ethnobotanical survey revealed that preparations of the plant are used in the treatment of central nervous system-related disorders including convulsion. This study was conducted to investigate the effect of...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.0211
更新日期：2013-09-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
abstract：:In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury model in rats. Result...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.0175
更新日期：2010-08-01 00:00:00
abstract：:Propolis is a natural bee product, and it has many effects, including antioxidant, anti-inflammatory, antihepatotoxic, and anticancer activity. In this study, we aimed to explore the potential in vivo anti-inflammatory, antioxidant, and antiapoptotic properties of propolis extract on lipopolysaccharide (LPS)-induced i...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.0151
更新日期：2018-11-01 00:00:00
abstract：:Vegetables are considered to be the most affordable and sustainable sources of several micronutrients that are essential for physical and mental development, immune system functioning, and various metabolic processes in humans. However, their effectiveness as dietary sources of minerals is influenced by mineral-minera...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.252
更新日期：2007-09-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.4093
更新日期：2018-07-01 00:00:00
abstract：:Aerial parts of Medicago sativa L. have been used as food and its consumption has been associated with health benefits, one among the most important being menopausal symptoms control. This work was aimed to explore possible pharmacological effects of two new alfalfa-derived products that have recently emerged as daily...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2016.0024
更新日期：2016-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.9.290
更新日期：2006-07-01 00:00:00
abstract：:Since ancient times, oak wood polyphenols are consumed concomitantly with beverages that are stored and aged in oak wood barrels. Among these polyphenols are roburins, which belong to the class of ellagitannins and only occur in oak. To date, water-extracted standardized French Quercus robur wood extract, commercially...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2020.0165
更新日期：2021-01-28 00:00:00
abstract：:Kefir is an association of microrganisms generally grown in milk, with known probiotic activities identified from its soured suspensions. Aqueous media are also able to grow kefir, but little is known about the probiotic properties of its fermented products. This work aimed to evaluate some probiotic properties of a c...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2007.329
更新日期：2008-06-01 00:00:00
abstract：:The plant extracts of 17 commonly used Indian medicinal plants were examined for their possible regulatory effect on nitric oxide (NO) levels using sodium nitroprusside as an NO donor in vitro. Most of the plant extracts tested demonstrated direct scavenging of NO and exhibited significant activity. The potency of sca...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2004.7.343
更新日期：2004-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.0125
更新日期：2015-05-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/109662001753165747
更新日期：2001-10-01 00:00:00
abstract：:Overwhelming evidence indicates that consumption of fruits and vegetables with antioxidant properties correlates with reduced risk for cancers, including leukemia. Carrots contain beneficial agents, such as β-carotene and polyacetylenes, which could be effective in the treatment of leukemia. This study investigated th...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2010.0284
更新日期：2011-11-01 00:00:00
abstract：:Frondoside A, a major triterpene glycoside from North Atlantic commercially harvested sea cucumber Cucumaria frondosa, possesses strong immunomodulatory properties in subtoxic doses. Frondoside A stimulates lysosomal activity of mouse macrophages in vivo at a maximal effective stimulatory dose of 0.2 microg per mouse ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2007.0530
更新日期：2008-09-01 00:00:00
abstract：:Allium cepa (Family Liliaceae) is a reputed Indian medicinal herb that is prescribed as an effective remedy for several ailments in the Ayurvedic system of medicine. The aim of this study was to evaluate its efficacy against various events responsible for Type I allergic reactions. A herbal fraction (ALC-02) from A. c...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2007.0642
更新日期：2009-04-01 00:00:00
abstract：:Safety of intravenous (i.v.) or intrapulmonary administration of different concentrations of honey and their effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride (CCl(4))-induced liver damage were studied. Healthy sheep of either sex, 6-8 months old, wer...
journal_title：Journal of medicinal food
pub_type： 杂志文章
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更新日期：2003-10-01 00:00:00
abstract：:Commercial coenzyme Q(10) (CoQ(10)) and alpha-tocopherol (vitamin E) formulations often show poor intestinal absorption. Delivery of CoQ(10) and vitamin E was enhanced when used with a new formulation, NanoSolve (Lipoid GmbH, Ludwigshafen, Germany), as shown by an open, comparative monocenter, crossover study of 24 vo...
journal_title：Journal of medicinal food
pub_type： 杂志文章,随机对照试验
doi：10.1089/jmf.2006.254
更新日期：2007-12-01 00:00:00
abstract：:This study investigated the effects and possible mechanism of ferulic acid, a naturally occurring phenolic compound, on endogenous glutamate release in the nerve terminals of the cerebral cortex in rats. Results show that ferulic acid inhibited the release of glutamate evoked by the K⁺ channel blocker 4-aminopyridine ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.2387
更新日期：2013-02-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.0132
更新日期：2015-08-01 00:00:00
abstract：:Dietary patterns high in fat influence local and systemic oxidative stress through adipose tissue (AT) accrual and increased reactive oxygen species generation. Lycopene, a carotenoid with antioxidant functionality, may mitigate excess oxidative stress, yet the lipophilic nature of this compound may limit its function...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2020.0064
更新日期：2020-07-15 00:00:00
abstract：:Although hydrogen peroxide (H₂O₂) is one of the major antibacterial factors in most honeys, it does not accumulate in medical-grade manuka honey. The goal of this study was to investigate the effect of artificially added methylglyoxal (MGO) on H₂O₂ accumulation in natural non-manuka honeys. H₂O₂ concentrations in the ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.0201
更新日期：2014-02-01 00:00:00
