[Circulating citrulline levels: a biomarker for intestinal functionality assessment].

Abstract:

:Circulating citrulline is emerging as an innovating biomarker candidate for assessment of intestinal function. Amino acid synthesized by enterocytes of intestinal mucosal, citrulline is not included in proteins or nutrition products and is a precursor for production of arginine by the kidney. Plasma citrulline is, in clinical situation, an established biomarker of enterocyte functional metabolic mass (trophicity) in children and in adult patients due to its high relation to active functional small bowel remnant length in intestinal diseases (short bowel, extensive enteropathies, intestinal toxicity of chemotherapy and radiotherapy. Plasma citrulline concentration (30-50  μmol/L), independent of nutritional status, if less than 10  μmol/L can give an objective threshold for nutrition parenteral use in case of intestinal failure due to enterocyte abnormalities or lack. Its regular dosage allows the monitoring of intestinal function except in case of significant renal failure.

journal_name

Ann Biol Clin (Paris)

authors

Crenn P,Hanachi M,Neveux N,Cynober L

doi

10.1684/abc.2011.0609

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

513-21

issue

5

eissn

0003-3898

issn

1950-6112

pii

abc.2011.0609

journal_volume

69

pub_type

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