[Determination of serum methadone with an immunologic kit and comparison with a liquid chromatography method].

Abstract:

:Therapeutic monitoring of patients participating in methadone maintenance programmes requires the qualitative or quantitative determination of methadone in urine before and during treatment. Generally immunoassay techniques are used for this determination, but more and more often measurement of plasma or serum levels are required by the physician. The possibility of adapting a commercially available FPIA kit (TDX ABBOTT) for urinary assays to the serum determinations was investigated. The specific modifications of the method and the dilution conditions for high concentrations are described. Results were compared with those obtained by liquid chromatography.

journal_name

Ann Biol Clin (Paris)

authors

Dessalles MC,Gasdeblay S,Mahuzier G

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

203-9

issue

5

eissn

0003-3898

issn

1950-6112

journal_volume

54

pub_type

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