Abstract:
OBJECTIVE:Visual spatial learning is impaired in mild cognitive impairment (MCI) although the nature of this impairment is not clear. This study investigated the nature and magnitude of errors made by adults with amnestic MCI (aMCI) when learning pattern-location paired associations in a continuous manner. METHOD:Visual associate learning was measured using the Continuous Paired Associate Learning (CPAL) task in which 30 adults who met clinical criteria for aMCI and 30 matched controls were required to learn a set of associations between patterns and locations across increasing memory loads (two, four, six, and eight). RESULTS:As hypothesized, the aMCI group made more total errors than controls for all memory loads above two. However, the rate of increase in errors with memory load in the aMCI group was approximately twice that for controls. CONCLUSIONS:In controls, errors on the CPAL task reflected almost exclusively difficulty in memory. In the aMCI group, errors on the CPAL reflected limitations in associative learning but also in short-term memory and response monitoring. These results suggest that impairments in specific aspects of executive function and working memory might contribute to poor performance on visual paired associate learning in aMCI.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Harel BT,Darby D,Pietrzak RH,Ellis KA,Snyder PJ,Maruff Pdoi
10.1037/a0024237subject
Has Abstractpub_date
2011-11-01 00:00:00pages
752-62issue
6eissn
0894-4105issn
1931-1559pii
2011-13414-001journal_volume
25pub_type
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