Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness.

Abstract:

OBJECTIVE:The authors examined associations between complementary fronto-temporal structural brain measures (gyrification, cortical thickness) and neurocognitive profiles in a multimorbid, socially marginalized sample. METHOD:Participants were recruited from single-room occupancy hotels and a downtown community courthouse (N = 299) and grouped on multiple neurocognitive domains using cluster analysis. Subsequently, the authors evaluated whether the fronto-temporal brain indices, and proxy measures of neurodevelopment and acquired brain insult/risk exposure differentiated members of the 3 distinct neurocognitive clusters. RESULTS:Greater frontal and temporal gyrification and more proxies of aberrant neurodevelopment were associated with the lowest functioning neurocognitive cluster (Cluster 3). Further, for older participants (50+ years), increased cortical thickness in frontal regions was associated with the higher functioning neurocognitive cluster (Cluster 1). Finally, the greatest acquired brain insult/risk exposure was associated with the cluster characterized by selective decision-making impairment (Cluster 2). CONCLUSIONS:Fronto-temporal structural brain indices, and proxies of neurodevelopment and acquired brain insult/risk exposure were differentially associated with neurocognitive profiles in socially marginalized persons. These findings highlight the unique pathways to neurocognitive impairment in a heterogeneous population and help to clarify the vulnerabilities confronted by different subgroups. (PsycINFO Database Record

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Gicas KM,Giesbrecht CJ,Panenka WJ,Lang DJ,Smith GN,Vila-Rodriguez F,Leonova O,Jones AA,Barr AM,Procyshyn RM,Buchanan T,MacEwan GW,Su W,Vertinsky AT,Rauscher A,Honer WG,Thornton AE

doi

10.1037/neu0000304

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

28-43

issue

1

eissn

0894-4105

issn

1931-1559

pii

2016-45103-001

journal_volume

31

pub_type

杂志文章
  • Time perception and reproduction in young adults with attention deficit hyperactivity disorder.

    abstract::Adults with attention deficit hyperactivity disorder (ADHD; n = 104) were compared with a control group (n = 64) on time estimation and reproduction tasks. Results were unaffected by ADHD subtype or gender. The ADHD group provided larger time estimations than the control group, particularly at long intervals. This bec...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.15.3.351

    authors: Barkley RA,Murphy KR,Bush T

    更新日期:2001-07-01 00:00:00

  • Cognitive, clinical, and functional characteristics of verbally superior schizophrenia patients.

    abstract::The existence of small numbers of schizophrenia patients with superior ability in specific cognitive domains is implied by meta-analytic evidence as well as by occasional empirical reports. The authors identified 25 patients with superior (i.e., > or =90th percentile) ability on the Vocabulary subtest of the Wechsler ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.22.3.321

    authors: Heinrichs RW,Miles AA,Smith D,Zargarian T,Vaz SM,Goldberg JO,Ammari N

    更新日期:2008-05-01 00:00:00

  • Combined genetic influences on episodic memory decline in older adults without dementia.

    abstract:OBJECTIVE:Although heritability explains a large proportion of the variance in old-age cognition, studies on the influence of specific genes have been inconclusive. We investigated the individual and combined effects of four single polymorphisms, previously associated with episodic memory, on cognitive performance and ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000637

    authors: Laukka EJ,Köhncke Y,Papenberg G,Fratiglioni L,Bäckman L

    更新日期:2020-09-01 00:00:00

  • A meta-analysis on the impact of psychiatric disorders and maltreatment on cognition.

    abstract:OBJECTIVE:Few studies have attempted to describe the range of cognitive impairments in individuals with psychiatric disorders who experienced maltreatment as children. The aims of this meta-analysis were to establish the impact of maltreatment and psychiatric disorders on cognition, and to examine the change in impact ...

    journal_title:Neuropsychology

    pub_type: 杂志文章,meta分析

    doi:10.1037/neu0000228

    authors: Masson M,East-Richard C,Cellard C

    更新日期:2016-02-01 00:00:00

  • Neuropsychological impairment among manic, depressed, and mixed-episode inpatients with bipolar disorder.

    abstract::Previous research has demonstrated broad neurobehavioral abnormalities in bipolar affective disorder (cf. G. Cassens, L. Wolfe, & M. Zola, 1990). However, there have been no comparisons of neuropsychological function across patients with manic, depressed, or mixed subtypes. In the present study, 37 manic, 24 mixed-epi...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.16.1.84

    authors: Basso MR,Lowery N,Neel J,Purdie R,Bornstein RA

    更新日期:2002-01-01 00:00:00

  • A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demands.

    abstract::This study identified the brain activations associated with auditory vigilance tasks, using functional magnetic resonance imaging. We created auditory continuous performance tests (CPTs) in which a demanding task (working memory task) was made more difficult than a simple vigilance task by increasing working memory an...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037//0894-4105.12.4.505

    authors: Seidman LJ,Breiter HC,Goodman JM,Goldstein JM,Woodruff PW,O'Craven K,Savoy R,Tsuang MT,Rosen BR

    更新日期:1998-10-01 00:00:00

  • Regional cerebral volume loss associated with verbal learning and memory in dementia of the Alzheimer type.

    abstract::Twenty-seven research participants with dementia of the Alzheimer type were studied with the California Verbal Learning Test (D. C. Delis, J. H. Kramer, E. Kaplan, & B. A. Ober, 1987) and standardized volume measures of the mesial temporal cortical gray matter, neocortical gray matter, thalamus, and caudate nuclei, fr...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037//0894-4105.13.2.188

    authors: Stout JC,Bondi MW,Jernigan TL,Archibald SL,Delis DC,Salmon DP

    更新日期:1999-04-01 00:00:00

  • Evaluation of a model of attention with confirmatory factor analysis.

    abstract::Structural equation modeling (specifically, analysis of moment structures; J. L. Arbuckle, 1996) was used to evaluate the goodness of fit of a model of components of attention (A. F. Mirsky, B. J. Anthony, C. C. Duncan, M. B. Aheam, & S. G. Kellam, 1991) to neuropsychological test data from 2 samples. One sample consi...

    journal_title:Neuropsychology

    pub_type: 杂志文章,meta分析

    doi:10.1037//0894-4105.14.2.201

    authors: Strauss ME,Thompson P,Adams NL,Redline S,Burant C

    更新日期:2000-04-01 00:00:00

  • Individual differences in lateralization: effects of gender and handedness.

    abstract::Male and female left- and right-handers participated in 3 experiments designed to investigate 3 components of performance asymmetry in lateralized tasks. Experiment 1 used a consonant-vowel-consonant (CVC) identification task measuring quantitative differences in hemispheric abilities and hemispheric control and quali...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037//0894-4105.11.4.562

    authors: Eviatar Z,Hellige JB,Zaidel E

    更新日期:1997-10-01 00:00:00

  • Gender-related dissociations of categorical fluency in normal subjects and in subjects with Alzheimer's disease.

    abstract::Semantic fluency tasks, with the categories of birds and furniture as stimuli, were administered to normal subjects and patients with Alzheimer's disease (AD). Normal subjects showed a gender-related double dissociation consistent with the literature data because men were more fluent with the birds category and women ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.21.2.207

    authors: Marra C,Ferraccioli M,Gainotti G

    更新日期:2007-03-01 00:00:00

  • Abstract reasoning in autism: a dissociation between concept formation and concept identification.

    abstract::The concept identification and concept formation aspects of abstract reasoning were examined in 90 nonmentally retarded individuals with autism and 107 normal controls. It was hypothesized that pronounced deficits would be found on concept formation tests, whereas performance on concept identification tests would be r...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.16.3.327

    authors: Minshew NJ,Meyer J,Goldstein G

    更新日期:2002-07-01 00:00:00

  • HIV-associated prospective memory impairment increases risk of dependence in everyday functioning.

    abstract::HIV infection is associated with impairments in prospective memory (ProM), an aspect of episodic memory that refers to the ability to execute a future intention, such as remembering to take a medication at a specific time. The current study sought to examine the relationship between HIV-associated ProM impairment and ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.22.1.110

    authors: Woods SP,Iudicello JE,Moran LM,Carey CL,Dawson MS,Grant I,HIV Neurobehavioral Research Center Group.

    更新日期:2008-01-01 00:00:00

  • Verbal fluency in male and female schizophrenia patients: Different patterns of association with processing speed, working memory span, and clinical symptoms.

    abstract:OBJECTIVE:Decreased processing speed in schizophrenia patients has been identified as a major impairment factor in various neuropsychological domains. Working memory span has been found to be involved in several deep or effortful cognitive processes. We investigated the impact that these 2 cognitive functions may have ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000394

    authors: Brébion G,Stephan-Otto C,Ochoa S,Nieto L,Contel M,Usall J

    更新日期:2018-01-01 00:00:00

  • The thin line between reality and imagination: The imagination inflation effect in Korsakoff's syndrome.

    abstract:OBJECTIVE:The imagination inflation effect, which is a form of memory distortion, occurs when imagining an event that never happened may increase the tendency to falsely remember that it really occurred. We investigated this effect in Korsakoff's syndrome. METHOD:Our procedures consisted of 2 sessions and a recognitio...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000635

    authors: El Haj M,Robin F

    更新日期:2020-07-01 00:00:00

  • Self-imagining enhances recognition memory in memory-impaired individuals with neurological damage.

    abstract:OBJECTIVE:The ability to imagine an elaborative event from a personal perspective relies on several cognitive processes that may potentially enhance subsequent memory for the event, including visual imagery, semantic elaboration, emotional processing, and self-referential processing. In an effort to find a novel strate...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037/a0020318

    authors: Grilli MD,Glisky EL

    更新日期:2010-11-01 00:00:00

  • Normative data for verbal fluency in healthy Latin American adults: Letter M, and fruits and occupations categories.

    abstract:OBJECTIVE:To generate normative data for the verbal fluency tests (VFT-letter M, fruits, and occupations categories) in Spanish-speaking adult populations, with country-specific adjustments for age, education, and sex when appropriate. METHOD:The sample consisted of 3,977 healthy adults from 11 countries in Latin Amer...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000518

    authors: Rivera D,Olabarrieta-Landa L,Van der Elst W,Gonzalez I,Rodríguez-Agudelo Y,Aguayo Arelis A,Rodriguez-Irizarry W,García de la Cadena C,Arango-Lasprilla JC

    更新日期:2019-03-01 00:00:00

  • Reading in developmental prosopagnosia: Evidence for a dissociation between word and face recognition.

    abstract:OBJECTIVE:Recent models suggest that face and word recognition may rely on overlapping cognitive processes and neural regions. In support of this notion, face recognition deficits have been demonstrated in developmental dyslexia. Here we test whether the opposite association can also be found, that is, impaired reading...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000428

    authors: Starrfelt R,Klargaard SK,Petersen A,Gerlach C

    更新日期:2018-02-01 00:00:00

  • Attentional shifting and disengagement in Rett syndrome.

    abstract:OBJECTIVE:The purpose of the present study was to deepen our understanding of attention (a core cognitive ability) in Rett syndrome (RTT), an x-linked neurodevelopmental disorder caused by mutations in the MECP2 gene. We focused on 2 key aspects of visual orienting-shifting and disengaging attention-both of which are c...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000515

    authors: Rose SA,Wass S,Jankowski JJ,Feldman JF,Djukic A

    更新日期:2019-03-01 00:00:00

  • Reading and arithmetic in adolescents with autism spectrum disorders: peaks and dips in attainment.

    abstract::In describing academic attainment in autism spectrum disorders (ASD), results are typically reported at the group mean level. This may mask subgroups of individuals for whom academic achievement is incommensurate with intellectual ability. The authors tested the IQ, literacy, and mathematical abilities of a large grou...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0016360

    authors: Jones CR,Happé F,Golden H,Marsden AJ,Tregay J,Simonoff E,Pickles A,Baird G,Charman T

    更新日期:2009-11-01 00:00:00

  • Contribution of organizational strategy to verbal learning and memory in adults with attention-deficit/hyperactivity disorder.

    abstract::Statistical mediation modeling was used to test the hypothesis that poor use of a semantic organizational strategy contributes to verbal learning and memory deficits in adults with attention-deficit/hyperactivity disorder (ADHD). Comparison of 28 adults with ADHD and 34 healthy controls revealed lower performance by t...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.18.1.78

    authors: Roth RM,Wishart HA,Flashman LA,Riordan HJ,Huey L,Saykin AJ

    更新日期:2004-01-01 00:00:00

  • International growth of neuropsychology.

    abstract:OBJECTIVE:Twenty-five years ago, the field of neuropsychology was well established in North America, Europe, and Australia, with less presence elsewhere. This article discusses the development of neuropsychology over the last 25 years in other regions. METHOD:The growth of neuropsychology in Asia, Africa, the Middle E...

    journal_title:Neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1037/neu0000415

    authors: Ponsford J

    更新日期:2017-11-01 00:00:00

  • The neural correlates of implicit sequence learning in schizophrenia.

    abstract::Twenty-seven schizophrenia spectrum patients and 25 healthy controls performed a probabilistic version of the serial reaction time task (SRT) that included sequence trials embedded within random trials. Patients showed diminished, yet measurable, sequence learning. Postexperimental analyses revealed that a group of pa...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.21.6.761

    authors: Marvel CL,Turner BM,O'Leary DS,Johnson HJ,Pierson RK,Ponto LL,Andreasen NC

    更新日期:2007-11-01 00:00:00

  • The relationship between working memory capacity and broad measures of cognitive ability in healthy adults and people with schizophrenia.

    abstract:OBJECTIVE:Working memory (WM) capacity, typically measured with cognitively complex span tasks, is correlated with higher order cognitive abilities in healthy adults. The goals of this study were to determine whether a more focused measure of visual WM storage capacity would show similar higher order ability correlatio...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0032060

    authors: Johnson MK,McMahon RP,Robinson BM,Harvey AN,Hahn B,Leonard CJ,Luck SJ,Gold JM

    更新日期:2013-03-01 00:00:00

  • Strategy bias in the emotion regulation of high trait anxiety individuals: An investigation of underlying neural signatures using ERPs.

    abstract:OBJECTIVE:Previous studies have employed self-report measures to investigate emotion regulation (ER) strategy biases in individuals with anxiety. We investigated the neural signatures underlying ER strategy biases. METHOD:Twenty individuals with high trait anxiety (HTA) and twenty individuals with low trait anxiety (L...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000471

    authors: Pan DN,Wang Y,Li X

    更新日期:2019-01-01 00:00:00

  • Neurocognitive intra-individual variability within HIV+ adults with and without current substance use.

    abstract:OBJECTIVE:HIV infection and current substance use (SU) are linked to cognitive and functional deficits, yet findings on their combined effects are mixed. Neurocognitive intraindividual variability, measured as dispersion of scores across a neuropsychological battery, is associated with worse cognitive outcomes and func...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000612

    authors: Arce Rentería M,Byrd D,Coulehan K,Miranda C,Fuentes A,Rosario AK,Morris EP,Rivera Mindt M

    更新日期:2020-03-01 00:00:00

  • Diverse attention deficits in patients with neurologically symptomatic and asymptomatic Wilson's disease.

    abstract:OBJECTIVE:Cognitive deficits in patients with Wilson's disease (WD) have been reported in several studies, but there was no detailed analysis of the various components of attention, one of the most significant factors of the executive system. Our study determined the pattern of deficits in attention subsystems in WD pa...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000103

    authors: Iwański S,Seniów J,Leśniak M,Litwin T,Członkowska A

    更新日期:2015-01-01 00:00:00

  • Emotion perception after moderate-severe traumatic brain injury: The valence effect and the role of working memory, processing speed, and nonverbal reasoning.

    abstract:OBJECTIVE:Traumatic brain injury (TBI) impairs emotion perception. Perception of negative emotions (sadness, disgust, fear, and anger) is reportedly affected more than positive (happiness and surprise) ones. It has been argued that this reflects a specialized neural network underpinning negative emotions that is vulner...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000171

    authors: Rosenberg H,Dethier M,Kessels RP,Westbrook RF,McDonald S

    更新日期:2015-07-01 00:00:00

  • Longitudinal analysis of phonemic clustering and switching during word-list generation in Huntington's disease.

    abstract::Two characteristics of word-list generation performance are forming clusters (i.e., contiguous words from the same subcategory) and switching among them. Patients with frontal lobe pathology show reduced switching on letter-cued word generation tasks, and clustering has been associated with temporal lobe functioning. ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.13.4.525

    authors: Rich JB,Troyer AK,Bylsma FW,Brandt J

    更新日期:1999-10-01 00:00:00

  • Mental-orientation: A new approach to assessing patients across the Alzheimer's disease spectrum.

    abstract:OBJECTIVE:This study aims to assess the role of mental-orientation in the diagnosis of mild cognitive impairment and Alzheimer's disease using a novel task. METHOD:A behavioral study (Experiment 1) compared the mental-orientation task to standard neuropsychological tests in patients across the Alzheimer's disease spec...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000463

    authors: Peters-Founshtein G,Peer M,Rein Y,Kahana Merhavi S,Meiner Z,Arzy S

    更新日期:2018-09-01 00:00:00

  • Patients with Parkinson's disease display a dopamine therapy related negative bias and an enlarged range in emotional responses to facial emotional stimuli.

    abstract:OBJECTIVE:The literature on emotional processing in Parkinson's disease (PD) patients shows mixed results. This may be because of various methodological and/or patient-related differences, such as failing to adjust for cognitive functioning, depression, and/or mood. METHOD:In the current study, we tested PD patients a...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000371

    authors: Lundqvist D,Svärd J,Michelgård Palmquist Å,Fischer H,Svenningsson P

    更新日期:2017-09-01 00:00:00