Abstract:
OBJECTIVE:Repetitive transcranial magnetic stimulation (rTMS) has been shown to have clinically beneficial effects in altering the perception of auditory hallucinations (AH) in patients with schizophrenia. However, the mode of action is not clear. Recent neuroimaging findings indicate that rTMS has the potential to induce not only local effects but also changes in remote, functionally connected brain regions. Frontotemporal dysconnectivity has been proposed as a mechanism leading to psychotic symptoms in schizophrenia. The current study examines functional connectivity between temporal and frontal brain regions after rTMS and the implications for AH in schizophrenia. METHOD:A connectivity analysis was conducted on the fMRI data of 11 healthy controls receiving rTMS, compared with 11 matched subjects receiving sham TMS, to the temporoparietal junction, before engaging in a task associated with robust frontotemporal activation. RESULTS:Compared to the control group, the rTMS group showed an altered frontotemporal connectivity with stronger connectivity between the right temporoparietal cortex and the dorsolateral prefrontal cortex and the angular gyrus. CONCLUSION:This finding provides preliminary evidence for the hypothesis that normalizing the functional connectivity between the temporoparietal and frontal brain regions may underlie the therapeutic effect of rTMS on AH in schizophrenia.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Gromann PM,Tracy DK,Giampietro V,Brammer MJ,Krabbendam L,Shergill SSdoi
10.1037/a0026603subject
Has Abstractpub_date
2012-01-01 00:00:00pages
127-32issue
1eissn
0894-4105issn
1931-1559pii
2011-29901-002journal_volume
26pub_type
杂志文章,随机对照试验相关文献
NEUROPSYCHOLOGY文献大全abstract::One of the great mysteries of the brain, which has puzzled all-time students of brain form and function, is the contralateral organization of the forebrain and the crossings of its major afferent and efferent connections. As a novel explanation, two recent studies have proposed that the rostral part of the head, inclu...
journal_title:Neuropsychology
pub_type: 评论,杂志文章
doi:10.1037/neu0000163
更新日期:2015-09-01 00:00:00
abstract::Impairment in the inhibitory mechanism of visual selective attention in patients with Parkinson's disease (PD) is controversial. The present study sought to understand disparate findings in a manner analogous to the relative preservation of exogenously evoked movement and impairment of endogenously evoked movement. Th...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/0894-4105.20.3.370
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:HIV infection and current substance use (SU) are linked to cognitive and functional deficits, yet findings on their combined effects are mixed. Neurocognitive intraindividual variability, measured as dispersion of scores across a neuropsychological battery, is associated with worse cognitive outcomes and func...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000612
更新日期:2020-03-01 00:00:00
abstract::Two studies tested the specificity of the neurocognitive profile of women with fragile X syndrome (FXS). First, women with an FXS full mutation were compared with women with a premutation and women without FXS who grew up in FXS families. Women with FXS had a significantly lower IQ than the other groups, and analyses ...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:Deficits in cognitive flexibility have been suggested to underlie the repetitive and stereotyped behavior in individuals with autism spectrum disorders (ASD). Because cognitive flexibility is primarily mediated by the frontal lobe, where structural and functional abnormalities have been extensively found in t...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000231
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To characterize the mediation of attention and action in space following traumatic brain injury (TBI). METHOD:Two exploratory analyses were performed to determine the influence of spatial 'Aiming' motor versus spatial 'Where' bias on line bisection in TBI participants. The first experiment compared performan...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000252
更新日期:2016-09-01 00:00:00
abstract::The hypothesis that music training can improve verbal memory was tested in children. The results showed that children with music training demonstrated better verbal but not visual memory than did their counterparts without such training. When these children were followed up after a year, those who had begun or continu...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/0894-4105.17.3.439
更新日期:2003-07-01 00:00:00
abstract::To evaluate the effect of age at various conditioned stimulus (CS)-unconditioned stimulus (US) intervals, 144 young, middle-aged, and older adults were tested on eyeblink classical conditioning at CS-US intervals of 500, 1,000, or 1,500 ms. Reaction time, response timing, motor learning, declarative memory, and attent...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037//0894-4105.13.1.90
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Two-alternative forced-choice tasks are widely used to gain insight into specific areas of enhancement or impairment in individuals with autism spectrum disorder (ASD). Data arising from these tasks have been used to support myriad theories regarding the integrity, or otherwise, of particular brain areas or c...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000320
更新日期:2017-02-01 00:00:00
abstract::In describing academic attainment in autism spectrum disorders (ASD), results are typically reported at the group mean level. This may mask subgroups of individuals for whom academic achievement is incommensurate with intellectual ability. The authors tested the IQ, literacy, and mathematical abilities of a large grou...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/a0016360
更新日期:2009-11-01 00:00:00
abstract::Attentional problems are a common sequelae of closed-head injury (CHI). Research in the area of selective attention has pointed to the role of inhibitory mechanisms in the suppression of irrelevant information. In the current study, a negative priming paradigm was used to assess the inhibitory mechanisms of individual...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037//0894-4105.14.2.310
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:A critical barrier to the understanding of disruptions to cognitive flexibility following sports-related concussion is the use of assessments that conflate shifts of visuospatial attention and contextual rules. Because these dissociable forms of cognitive flexibility are subserved by distinct neural networks,...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000475
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Cognitive deficits in patients with Wilson's disease (WD) have been reported in several studies, but there was no detailed analysis of the various components of attention, one of the most significant factors of the executive system. Our study determined the pattern of deficits in attention subsystems in WD pa...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000103
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The ability to imagine an elaborative event from a personal perspective relies on several cognitive processes that may potentially enhance subsequent memory for the event, including visual imagery, semantic elaboration, emotional processing, and self-referential processing. In an effort to find a novel strate...
journal_title:Neuropsychology
pub_type: 临床试验,杂志文章
doi:10.1037/a0020318
更新日期:2010-11-01 00:00:00
abstract::The authors evaluated multiple memory processes and explored their contributions to everyday functional limitations in persons with mild cognitive impairment (MCI). Participants included individuals with amnestic MCI, nonamnestic MCI, and healthy older adults. As expected, the amnestic MCI group performed more poorly ...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/a0014186
更新日期:2009-03-01 00:00:00
abstract::The role of semantic organization in verbal memory efficiency in schizophrenia was investigated. Patients and healthy controls were administered a free-recall task involving 1 nonsemantically organizable list, 1 list organizable in semantic categories with typical instances, and 1 list organizable in semantic categori...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/0894-4105.18.2.378
更新日期:2004-04-01 00:00:00
abstract:: Objective: White matter (WM) changes detected using diffusion tensor imaging (DTI) are reportedly related to cognitive outcomes following traumatic brain injury (TBI), but much existing research is underpowered or has only examined general outcomes, rather than cognitive f...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000690
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To characterize variability in daily life functioning among individuals with serious mental illness based on a naturalistic performance measure of grocery shopping and standard neuropsychological tasks using cluster analytic methods. METHODS:A naturalistic performance measure, the Test of Grocery Shopping Sk...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000700
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The authors examined associations between complementary fronto-temporal structural brain measures (gyrification, cortical thickness) and neurocognitive profiles in a multimorbid, socially marginalized sample. METHOD:Participants were recruited from single-room occupancy hotels and a downtown community courth...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000304
更新日期:2017-01-01 00:00:00
abstract::This exploratory study was conducted to increase understanding of neuropsychological test performance in those with blast-related mild traumatic brain injury (mTBI). The two variables of interest for their impact on test performance were presence of mTBI symptoms and history of posttraumatic stress disorder (PTSD). Fo...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/a0017966
更新日期:2010-03-01 00:00:00
abstract::This study examined the relationship between morphological structure of languages and performance asymmetries of native speakers in lateralized tasks. In 2 experiments, native speakers of English (concatenative morphology stem plus affix) and of Hebrew and Arabic (nonconcatenative root plus word-form morphology) were ...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/0894-4105.21.4.470
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:An increasing number of results show that specific language impairment (SLI) is often associated with impairments in executive functions (EF), but the nature, extent, and generality of these deficits is yet unclear. The aim of the paper is to present results from verbal and nonverbal tasks examining EF in chi...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000232
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Deficits in the ability to perceive time have been proposed as an etiologic mechanism in the development of the cognitive and behavioral characteristics associated with ADHD. However, previous studies testing the presence of timing deficits have produced idiosyncratic results. This is in large part due to the...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000562
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:It is well established that it is common for healthy adults to obtain one or more low scores when multiple neuropsychological tests are administered; however, very little is known about the normal frequency of high scores. The current study reports high-score base rates for the National Institutes of Health T...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000691
更新日期:2020-07-30 00:00:00
abstract:OBJECTIVE:The last 25 years have seen profound changes in neurocognitive rehabilitation that continue to motivate its evolution. Although the concept of nervous system plasticity was discussed by William James (1890), the foundation for experience-based plasticity had not reached the critical empirical mass to seriousl...
journal_title:Neuropsychology
pub_type: 杂志文章,评审
doi:10.1037/neu0000396
更新日期:2017-11-01 00:00:00
abstract::Individuals with dementia of the Alzheimer type (DAT; n = 53, ages 55-91), healthy older adults (n = 75, ages 59-91), and younger adults (n = 24, ages 18-24) performed a word-primed picture-naming task. Word primes were neutral (ready), semantically or phonologically related, or unrelated to the correct picture name. ...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/0894-4105.18.3.526
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:The current study examined whether year-to-year variability in cognitive performance differ between individuals cognitively unimpaired and individuals who subsequently develop dementia. METHOD:Analyses included a case-control sample of Baltimore Longitudinal Study of Aging (BLSA; mean [M] age = 69.90, standa...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/a0028686
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Behavioral studies of spatial navigation in aging indicate that orientation using an allocentric reference frame (object-centered orientation) is impaired, whereas orientation using egocentric processes (self-centered orientation) is not. It has been proposed that navigational deficits may result from more ge...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000084
更新日期:2014-09-01 00:00:00
abstract::Statistical mediation modeling was used to test the hypothesis that poor use of a semantic organizational strategy contributes to verbal learning and memory deficits in adults with attention-deficit/hyperactivity disorder (ADHD). Comparison of 28 adults with ADHD and 34 healthy controls revealed lower performance by t...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/0894-4105.18.1.78
更新日期:2004-01-01 00:00:00
abstract::The present study examined prospective and episodic memory in relation to age, functional independence, and hippocampal volume in younger to middle-aged adults with spina bifida myelomeningocele (SBM) and typically developing (TD) adults. Prospective and episodic memory, as well as hippocampal volume, was reduced in a...
journal_title:Neuropsychology
pub_type: 杂志文章
doi:10.1037/neu0000111
更新日期:2015-01-01 00:00:00