Abstract:
:Two studies tested the specificity of the neurocognitive profile of women with fragile X syndrome (FXS). First, women with an FXS full mutation were compared with women with a premutation and women without FXS who grew up in FXS families. Women with FXS had a significantly lower IQ than the other groups, and analyses of subtest profiles showed they had a relative weakness on Arithmetic and strength on Picture Completion. Women with FXS performed worse than the other groups on executive function, spatial ability, and visual memory. Next, women with FXS were compared with women without FXS matched on age and IQ. A similar IQ profile was found, but women with FXS were worse than controls only on executive function. The authors also examined which neurocognitive indices were related to the underlying biology of the disorder. Overall, the results indicated that executive rather than visuospatial deficits were primary in the neurocognitive profile of FXS.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Bennetto L,Pennington BF,Porter D,Taylor AK,Hagerman RJsubject
Has Abstractpub_date
2001-04-01 00:00:00pages
290-9issue
2eissn
0894-4105issn
1931-1559journal_volume
15pub_type
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