Profile of cognitive functioning in women with the fragile X mutation.

Abstract:

:Two studies tested the specificity of the neurocognitive profile of women with fragile X syndrome (FXS). First, women with an FXS full mutation were compared with women with a premutation and women without FXS who grew up in FXS families. Women with FXS had a significantly lower IQ than the other groups, and analyses of subtest profiles showed they had a relative weakness on Arithmetic and strength on Picture Completion. Women with FXS performed worse than the other groups on executive function, spatial ability, and visual memory. Next, women with FXS were compared with women without FXS matched on age and IQ. A similar IQ profile was found, but women with FXS were worse than controls only on executive function. The authors also examined which neurocognitive indices were related to the underlying biology of the disorder. Overall, the results indicated that executive rather than visuospatial deficits were primary in the neurocognitive profile of FXS.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Bennetto L,Pennington BF,Porter D,Taylor AK,Hagerman RJ

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

290-9

issue

2

eissn

0894-4105

issn

1931-1559

journal_volume

15

pub_type

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