Abstract:
:To assess the nature and magnitude of memory impairment in multiple sclerosis (MS), the authors analyzed quantitatively 36 studies comparing the memory performance of MS participants to healthy controls. The authors studied (a) the pattern of impairment across short-term memory (STM), working memory (WM), and long-term memory (LTM); (b) the moderating influence of retrieval support on LTM impairment; (c) the covariation of WM and LTM impairment; and (d) the moderating influence of clinical characteristics of the MS sample on memory impairment. The analyses revealed significant impairment across all memory domains and failed to support a retrieval-based account of LTM dysfunction in MS patients. In addition, robust associations were found between clinical features of MS and memory impairment. The findings suggest a more global pattern of memory deficits in MS than has been previously believed, with deficits clearly associated with neurological disability and disease course.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Thornton AE,Raz Ndoi
10.1037//0894-4105.11.3.357subject
Has Abstractpub_date
1997-07-01 00:00:00pages
357-66issue
3eissn
0894-4105issn
1931-1559journal_volume
11pub_type
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