Abstract:
:In this study, the cognitive and neurochemical factors underlying learned irrelevance, one of the mechanisms thought to be responsible for attentional set-shifting deficits in Parkinson's disease (PD), were investigated. In a visual discrimination learning task, the extent to which a target dimension was irrelevant prior to an extra-dimensional shift was varied. Twenty patients with PD and 22 healthy participants performed the task twice, with patients tested on and off L-dopa. The patients made more errors than control participants in the condition in which the target dimension was completely irrelevant prior to the extradimensional shift, but not when it was partially reinforced. Moreover, L-dopa had no effect on the patients' task performance, despite improving their working memory. These results confirm that learned irrelevance is a significant factor in accounting for attentional set-shifting deficits in patients with PD, although unlike other executive impairments in this group, the phenomenon appears to be unrelated to their central dopaminergic deficit.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Slabosz A,Lewis SJ,Smigasiewicz K,Szymura B,Barker RA,Owen AMdoi
10.1037/0894-4105.20.5.578subject
Has Abstractpub_date
2006-09-01 00:00:00pages
578-88issue
5eissn
0894-4105issn
1931-1559pii
2006-10978-008journal_volume
20pub_type
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