The role of learned irrelevance in attentional set-shifting impairments in Parkinson's disease.

Abstract:

:In this study, the cognitive and neurochemical factors underlying learned irrelevance, one of the mechanisms thought to be responsible for attentional set-shifting deficits in Parkinson's disease (PD), were investigated. In a visual discrimination learning task, the extent to which a target dimension was irrelevant prior to an extra-dimensional shift was varied. Twenty patients with PD and 22 healthy participants performed the task twice, with patients tested on and off L-dopa. The patients made more errors than control participants in the condition in which the target dimension was completely irrelevant prior to the extradimensional shift, but not when it was partially reinforced. Moreover, L-dopa had no effect on the patients' task performance, despite improving their working memory. These results confirm that learned irrelevance is a significant factor in accounting for attentional set-shifting deficits in patients with PD, although unlike other executive impairments in this group, the phenomenon appears to be unrelated to their central dopaminergic deficit.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Slabosz A,Lewis SJ,Smigasiewicz K,Szymura B,Barker RA,Owen AM

doi

10.1037/0894-4105.20.5.578

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

578-88

issue

5

eissn

0894-4105

issn

1931-1559

pii

2006-10978-008

journal_volume

20

pub_type

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