Effects of age, gender and time on receptor expression and anti-Aspergillus functions of human phagocytes.

abstract：:Accessory cell (A-cell) function in a Con A response was analyzed. Irradiated P388D1 cells efficiently induced a proliferative response to Con A of T cells purified from spleen cells, whereas paraformaldehyde-fixed P388D1 cells failed to serve as A cells. Although IL-1 containing culture supernatant (SN) of a macropha...

journal_title：Cellular immunology

authors： Kohno K,Kakiuchi T,Takeuchi M,Taira S,Nariuchi H

更新日期：1987-05-01 00:00:00

abstract：:The pim-1 gene encodes a serine/threonine protein kinase with expression restricted primarily to cells of hematopoietic lineage and is thought to play a role in the signal transduction events associated with lymphocyte activation. A rapid increase in pim-1 mRNA levels was found after stimulation of normal unseparated ...

journal_title：Cellular immunology

authors： Wingett D,Stone D,Davis WC,Magnuson NS

更新日期：1995-04-15 00:00:00

abstract：:Sialoadhesin (Sn) is a surface receptor expressed on macrophages in steady state conditions, but during inflammation, Sn can be upregulated both on macrophages and on circulating monocytes. It was shown for different species that Sn becomes internalized after binding with monoclonal antibodies. These features suggest ...

journal_title：Cellular immunology

authors： De Schryver M,Cappoen D,Elewaut D,Nauwynck HJ,Maes L,Caljon G,Cos P,Delputte PL

更新日期：2017-02-01 00:00:00

abstract：:Veto cells suppress generation of CD8(+) T cell immune responses in an antigen-specific manner, with specificity dictated by antigens on the veto cell surface. Activated bone marrow (ABM) veto cells belong to the NK cell type lineage and veto by clonally deleting antigen-specific precursor cytotoxic T cell lymphocyte ...

journal_title：Cellular immunology

authors： Chrobak P,Gress RE

更新日期：2001-03-15 00:00:00

abstract：:Aging leads to an increase in the proportion of cells that have the surface phenotype (CD45RBlo, CD44hi) characteristic of memory T lymphocytes and also to a decline in both the production of IL-2 and the response to this lymphokine. Several groups have reported an increase, with age, in the secretion of IL-4 in short...

journal_title：Cellular immunology

authors： Li SP,Miller RA

更新日期：1993-10-01 00:00:00

abstract：:Human leucocytes from peripheral blood and tonsil were examined for the presence of the IL-3 receptor using monoclonal antibodies directed to epitopes of the alpha and beta chains of the receptor. We found that the beta chain, common to IL-3, IL-5, and GM-CSF, was either present at low levels or not detected on the ma...

journal_title：Cellular immunology

authors： Macardle PJ,Chen Z,Shih CY,Huang CM,Weedon H,Sun Q,Lopez AF,Zola H

更新日期：1996-02-25 00:00:00

abstract：:Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

journal_title：Cellular immunology

authors： Miller CG,Justus DE,Jayaraman S,Kotwal GJ

更新日期：1995-05-01 00:00:00

abstract：:Heterotrimeric G-proteins control diverse biological processes by conveying signals from seven-transmembrane receptors to intracellular effectors. Although their signaling roles were originally ascribed to their GTP-bound alpha-subunits, more recent evidence points to the equally active roles played by their betagamma...

journal_title：Cellular immunology

authors： Dubeykovskiy A,McWhinney C,Robishaw JD

更新日期：2006-04-01 00:00:00

abstract：:Previous work in our laboratory established that individual complement components can be regulated in vivo by administration of specific antibody or immunocompetent cells to newborns and in vitro by administration of specific antibody to cultured peritoneal macrophages or splenic fragments. Antibody-induced suppressio...

journal_title：Cellular immunology

authors： Goldman JN,O'Rourke KS,Goldman MB

更新日期：1985-11-01 00:00:00

abstract：:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytoly...

journal_title：Cellular immunology

authors： Gallily R,Sher T,Ben-Av P,Loewenstein J

更新日期：1989-06-01 00:00:00

abstract：:We systematically investigated the impact of the relative maturation levels of dendritic cells (DCs) on their cell surface phenotype, expression of cytokines and chemokines/chemokine receptors (by DNA array and RNase protection analyses), biological activities, and abilities to induce tumor immunity. Mature DCs expres...

journal_title：Cellular immunology

authors： Chen Z,Dehm S,Bonham K,Kamencic H,Juurlink B,Zhang X,Gordon JR,Xiang J

更新日期：2001-11-25 00:00:00

abstract：:Natural suppressor (NS) cells, which nonspecifically suppress immune responses, are present in the spleen following exposure to radiation, chronic graft-versus-host disease, or cancer and in normal bone marrow. A model system is described which allows the study of cytokines activating and inhibiting NS cells, cytokine...

journal_title：Cellular immunology

authors： Moore SC,Theus SA,Barnett JB,Soderberg LS

更新日期：1992-05-01 00:00:00

abstract：:Previous studies with the lymphokine, histamine-releasing activity (HRA), showed that HRA consisted of a heterogeneous group of molecules. The possibility of using thoracic duct lymphocytes (TDL) as a source of large quantities of HRA has been investigated. Antigen-stimulated TDL synthesize and release HRA in quantiti...

journal_title：Cellular immunology

authors： Lett-Brown MA,Thueson DO,Plank DE,Langford MP,Grant JA

更新日期：1984-09-01 00:00:00

abstract：:It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cel...

journal_title：Cellular immunology

authors： Takeuchi T,Schlossman SF,Morimoto C

更新日期：1987-06-01 00:00:00

abstract：:Recently, we reported that the CD5 protein can bind to the B cell antigen CD72. So far, no functional evidence has been given for this interaction. We used soluble native CD5 and two anti-CD72 monoclonal antibodies, JT3 and WL225, produced and characterized in our laboratory in order to investigate the role of CD5 in ...

journal_title：Cellular immunology

authors： Van de Velde H,Thielemans K

更新日期：1996-08-25 00:00:00

abstract：:Varying the concentration of anti-CD3 immobilized on Sepharose beads allowed us to study both the inhibitory and the stimulatory effects of IL-4 on purified T cells and contrast IL-4 versus IL-2-driven T-cell proliferative responses. In the presence of low density immobilized anti-CD3, IL-4 was unable to stimulate pur...

journal_title：Cellular immunology

authors： Jones-Tiffany LA,Mehrotra PT,Horohov DW,Siegel J,Kozak RW

更新日期：1993-04-01 00:00:00

abstract：:We have examined signal transduction via membrane IgM (mIgM) in resting and cycling human B cells. Crosslinking mIgM on all of the cell types studied transduced a signal through the phosphatidylinositol pathway, producing inositol 1,4,5-trisphosphate and release of intracellular free calcium. These second messengers w...

journal_title：Cellular immunology

authors： Valentine MA,Bursten SL,Harris WE,Draves KE,Pollok BA,Ostrowski J,Bomsztyk K,Clark EA

更新日期：1992-05-01 00:00:00

abstract：:Nickel (Ni) can cause delayed-type hypersensitivity reactions, which are thought to be mediated by the accumulation of T cells into inflamed skin. Accumulated T cells at the developmental stages in metal allergy are poorly characterized because a suitable animal model has not been established. To investigate the accum...

journal_title：Cellular immunology

authors： Eguchi T,Kumagai K,Kobayashi H,Shigematsu H,Kitaura K,Suzuki S,Horikawa T,Hamada Y,Ogasawara K,Suzuki R

更新日期：2013-07-01 00:00:00

abstract：:Monoclonal-nonspecific suppressor factor (MNSF) is a lymphokine derived from murine T cell hybridoma. The target tissues are both LPS-stimulated B cells and Con A-stimulated T cells. Since the action of MNSF may be mediated by its binding to specific cell surface receptors, we characterized the mode of this binding. T...

journal_title：Cellular immunology

authors： Nakamura M,Ogawa H,Tsunematsu T

更新日期：1990-10-15 00:00:00

abstract：:In this paper, we examined the contribution of the lymphokine interleukin-6 (IL-6) to the growth of four virulent strains of Mycobacterium avium and the nature of the binding moieties on the mycobacteria. First, we showed that human or mouse recombinant interleukin-6 are potent growth factors for four strains of virul...

journal_title：Cellular immunology

authors： Denis M

更新日期：1992-04-15 00:00:00

abstract：:Earlier work from this laboratory revealed an increase in the level of null (Thy-1-, IgM-) lymphocytes in the maternal lymphoid organs during the first pregnancy in the mouse that was more pronounced during allogeneic pregnancy than during syngeneic pregnancy. In view of the suggestive evidence for the bone marrow ori...

journal_title：Cellular immunology

authors： Chatterjee-Hasrouni S,Parhar R,Lala PK

更新日期：1984-04-01 00:00:00

abstract：:Five thiol compounds including 2-mercaptoethanol (2-ME) were examined for their augmenting effects on in vitro antibody response to sheep erythrocytes. Three compounds were effective with the following order of activity; 2-ME greater than dithiothreitol greater than cysteamine. Glutathione and thioglycollate failed to...

journal_title：Cellular immunology

authors： Ohmori H,Yamamoto I

更新日期：1983-07-01 00:00:00

abstract：:Immunity to Schistosoma mansoni is regulated by an auto-anti-idiotypic network. The T cells in this network interact through soluble regulatory factors. These studies describe a soluble suppressor-inducer factor (TsiF) derived from TCR+ suppressor-inducer clone Q37. Q37 is the fusion product of CD4+ T cells derived fr...

journal_title：Cellular immunology

authors： Perrin PJ,Phillips SM

更新日期：1993-06-01 00:00:00

abstract：:Receptors for the Fc domain of IgG mediate target recognition, signal transduction, and effector functions including antibody-dependent cytolysis, phagocytosis, and phagolysosome formation. To better understand FcR-mediated functions and to identify potential therapeutic strategies, we employed cell-penetrating ("Troj...

journal_title：Cellular immunology

authors： Clark AJ,Petty HR

更新日期：2010-01-01 00:00:00

abstract：:Mice homozygous for either the generalized lymphoproliferative disease (gld) or the lymphoproliferation (lpr) nonallelic mutations develop similar syndromes combining systemic autoimmunity and lymphoproliferative disease. Though essentially recessive, the lpr and gld mutations may be expressed in the heterozygous stat...

journal_title：Cellular immunology

authors： Rosenblatt N,Hartmann KU,Loor F

更新日期：1994-07-01 00:00:00

abstract：:Dexamethasone is a potent anti-inflammatory and immunosupressive agent that has complex, yet incompletely defined, effects on the immune response. Here, we explored the effect of dexamethasone on the expression of TCR zeta chain and TCR/CD3-induced early signaling events in human T lymphocytes. Immunoblotting studies ...

journal_title：Cellular immunology

authors： Nambiar MP,Enyedy EJ,Fisher CU,Warke VG,Juang YT,Tsokos GC

更新日期：2001-02-25 00:00:00

abstract：:Immunosuppression is a well-established risk factor for Visceral Leishmaniasis. Post-immunosuppression leishmaniasis is characterized by an increase of parasite burden, hematopoietic disorders and unusual clinical manifestations. Although there are many reports on bone marrow findings in VL, less is known about the re...

journal_title：Cellular immunology

authors： Carvalho-Gontijo R,Moreira DR,Resende M,Costa-Silva MF,Peruhype-Magalhães V,Ribeiro CMF,Ribeiro DD,Silvestre R,Cordeiro-da-Silva A,Martins-Filho OA,Teixeira-Carvalho A

更新日期：2018-04-01 00:00:00

abstract：:This paper investigates the presence of HLA class I-restricted and tumor-specific cytotoxic T lymphocytes (CTL) in tumor sites of esophageal cancers. Five CTL lines were established from the metastatic lymph nodes or pleural effusion by incubation with interleukin-2 of tumor-infiltrating lymphocytes: cases 1 and 5, HL...

journal_title：Cellular immunology

authors： Toh U,Yamana H,Nakao M,Imai Y,Seki N,Takasu H,Kaneshige T,Fujita H,Shirouzu K,Itoh K

更新日期：1997-05-01 00:00:00

abstract：:Piper nigrum (Piperaceae) is commonly used as a spice and traditional medicine in many countries. P. nigrum has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the effect of P. nigrum on allergic asthma has not been known. This s...

journal_title：Cellular immunology

authors： Bui TT,Piao CH,Song CH,Shin HS,Shon DH,Chai OH

更新日期：2017-12-01 00:00:00

abstract：:Osteopontin (OPN) expression in tumors is associated with more aggressive tumor growth; however, several studies have suggested that OPN as a host protein can regulate tumor growth as well. OPN is produced by macrophages and T cells, and reportedly modifies macrophage function. Here, we have investigated the effect of...

journal_title：Cellular immunology

authors： Bourassa B,Monaghan S,Rittling SR

更新日期：2004-01-01 00:00:00