RNAi and small interfering RNAs in human disease therapeutic applications.

abstract：:Genomic research is expected to generate new types of complex observational data, changing the types of experiments as well as our understanding of biological processes. The investigation and definition of relationships among proteins is essential for understanding the function of each gene and the mechanisms of biolo...

journal_title：Trends in biotechnology

authors： Haberkorn U,Altmann A

更新日期：2003-06-01 00:00:00

abstract：:Patterned regular sieves and filters with comparable molecular dimensions hold great promise as an alternative to conventional polymeric gels and fibrous membranes to improve biomolecule separation. Recent developments of microfabricated nanofluidic sieves and filters have demonstrated superior performance for both an...

journal_title：Trends in biotechnology

authors： Fu J,Mao P,Han J

更新日期：2008-06-01 00:00:00

abstract：:Carotenoids are one of the most diverse classes of natural compounds. Plant carotenoids are composed of a C40 isoprenoid skeleton with or without epoxy, hydroxy and keto groups. They have fundamental roles in human nutrition as antioxidants and vitamin A precursors and their consumption is increasingly associated with...

journal_title：Trends in biotechnology

authors： Giuliano G,Tavazza R,Diretto G,Beyer P,Taylor MA

更新日期：2008-03-01 00:00:00

abstract：:Innovative fermentation processes are necessary for the cost-effective production of bulk chemicals from renewable resources. Current microbial processes are either anaerobic processes, with high yield and productivity, or less-efficient aerobic processes. Oxygen utilization plays an important role in energy generatio...

journal_title：Trends in biotechnology

authors： Weusthuis RA,Lamot I,van der Oost J,Sanders JP

更新日期：2011-04-01 00:00:00

abstract：:Modern biocatalysis is developing new and precise tools to improve a wide range of production processes, which reduce energy and raw material consumption and generate less waste and toxic side-products. Biocatalysis is also achieving new advances in environmental fields, from enzymatic bioremediation to the synthesis ...

journal_title：Trends in biotechnology

authors： Alcalde M,Ferrer M,Plou FJ,Ballesteros A

更新日期：2006-06-01 00:00:00

abstract：:Antibodies are able to both bind antigens and trigger the responses that eliminate them from circulation. All antibodies are glycosylated at conserved positions in their constant regions, and the presence of carbohydrate can be critical for antigen clearance functions such as complement activation. The structure of th...

journal_title：Trends in biotechnology

authors： Wright A,Morrison SL

更新日期：1997-01-01 00:00:00

abstract：:Current biopharmaceutical manufacturing strongly relies on using purification platform processes, offering harmonization of practices and speed-to-market. However, the ability of such processes to respond quickly to anticipated higher quality and capacity demands is under question. Here, we describe novel approaches f...

journal_title：Trends in biotechnology

authors： Nfor BK,Verhaert PD,van der Wielen LA,Hubbuch J,Ottens M

更新日期：2009-12-01 00:00:00

abstract：:Luminescence has assumed an important role in analytical biochemistry and molecular biology as an extremely sensitive method for determining the concentration of specific ions and molecules. The luminescent system of the jellyfish Aequorea victoria consists of the photoprotein aequorin, which contains the molecule coe...

journal_title：Trends in biotechnology

authors： Jones K,Hibbert F,Keenan M

更新日期：1999-12-01 00:00:00

abstract：:In recent years, entrapment of cells within spheres of Ca2+ alginate has become the most widely used technique for immobilizing living cells. This versatile method includes applications ranging from immobilization of living or dead cells in bioreactors, immobilization of plant protoplasts for micropropagation and immo...

journal_title：Trends in biotechnology

authors： Smidsrød O,Skjåk-Braek G

更新日期：1990-03-01 00:00:00

abstract：:Microbial consortia have been used in biotechnology processes, including fermentation, waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly engineering microbial consortia for diverse applications, including the bioproduction of medicines, biofuels, and biomaterials from inexpe...

journal_title：Trends in biotechnology

authors： McCarty NS,Ledesma-Amaro R

更新日期：2019-02-01 00:00:00

abstract：:The existence of a medicinal 'biotech revolution' has been widely accepted and promoted by academics, consultants, industry and government. This has generated expectations about significant improvements in the drug discovery process, healthcare and economic development that influence a considerable amount of policy-ma...

journal_title：Trends in biotechnology

authors： Nightingale P,Martin P

更新日期：2004-11-01 00:00:00

abstract：:Techniques to enable direct communication between the brain and computers/machines, such as the brain-computer interface (BCI) or the brain-machine interface (BMI), are gaining momentum in the neuroscientific realm, with potential applications ranging from medicine to general consumer electronics. Noninvasive BCI tech...

journal_title：Trends in biotechnology

authors： Min BK,Marzelli MJ,Yoo SS

更新日期：2010-11-01 00:00:00

abstract：:Bioelectrochemical power-to-gas (BEP2G) is considered a potentially convenient way of storing renewable surplus electricity in the form of methane. In methane-producing bioelectrochemical systems (BESs), carbon dioxide and electrical energy are converted into methane, using electrodes that supply either electrons or h...

journal_title：Trends in biotechnology

authors： Geppert F,Liu D,van Eerten-Jansen M,Weidner E,Buisman C,Ter Heijne A

更新日期：2016-11-01 00:00:00

abstract：:In situ 3D printing is an emerging technique designed for patient-specific needs and performed directly in the patient's tissues in the operating room. While this technology has progressed rapidly, several improvements are needed to push it forward for widespread utility, including ink formulations and optimization fo...

journal_title：Trends in biotechnology

authors： Agostinacchio F,Mu X,Dirè S,Motta A,Kaplan DL

更新日期：2020-12-02 00:00:00

abstract：:Microbial exopolysaccharides such as xanthan and dextran have been commercial products for many years; the search for new gelling agents has yielded gellan. Exopolysaccharides have many other novel properties to offer, and the discovery of immune modulation and tumouristasis by beta-D-glucans, and the use of bacterial...

journal_title：Trends in biotechnology

authors： Sutherland IW

更新日期：1998-01-01 00:00:00

abstract：:Advances in high-throughput DNA-sequencing techniques have given us the unprecedented ability to rapidly determine the nucleotide sequences of entire bacterial genomes. The application of these methods to the genomes of microbial pathogens, combined with efficient analytical tools and genome-scale approaches for study...

journal_title：Trends in biotechnology

authors： Smith DR

更新日期：1996-08-01 00:00:00

abstract：:Recent innovations in the materials used for bioprinting have enabled transformative gains in the resolution and architecture of 3D-printed engineered tissues. We focus here on one of these innovations, reported by Lee et al., which lowers the resolution limit for printing soft biomaterials. ...

journal_title：Trends in biotechnology

authors： Corbett DC,Olszewski E,Stevens K

更新日期：2019-11-01 00:00:00

abstract：:Psychrophilic anaerobic treatment is an attractive option for wastewaters that are discharged at moderate to low temperature. The expanded granular sludge bed (EGSB) reactor has been shown to be a feasible system for anaerobic treatment of mainly soluble and pre-acidified wastewater at temperatures of 5--10 degrees C....

journal_title：Trends in biotechnology

authors： Lettinga G,Rebac S,Zeeman G

更新日期：2001-09-01 00:00:00

abstract：:Carotenoids are antioxidants with considerable pharmaceutical potential. More than 600 carotenoid structures are known but their availability is limited owing to practical difficulties associated with chemical synthesis and isolation from microorganisms or plant tissue. To overcome some of these problems, heterologous...

journal_title：Trends in biotechnology

authors： Sandmann G,Albrecht M,Schnurr G,Knörzer O,Böger P

更新日期：1999-06-01 00:00:00

abstract：:A switch from a petroleum-based to a biobased economy requires the capacity to produce both high-value low-volume and low-value high-volume products. Recent evidence supports the development of microalgae-based microbial cell factories with the objective of establishing environmentally sustainable manufacturing soluti...

journal_title：Trends in biotechnology

authors： Butler T,Kapoore RV,Vaidyanathan S

更新日期：2020-06-01 00:00:00

abstract：:A major impact of genome projects on human health will be their contribution to the understanding of protein function. Proteins are the engines of biological systems, nearly all pharmaceuticals act on proteins and increasingly proteins themselves are used therapeutically. As biology enters the post-genomic era, resear...

journal_title：Trends in biotechnology

authors： Braun P,LaBaer J

更新日期：2003-09-01 00:00:00

abstract：:Although microorganisms have long been known as producers of edible oils, opportunities for their biotechnological exploitation are limited to the highest-value commodities. A recent attempt to develop a yeast oil cocoa-butter equivalent has not succeeded, not because of the inability to produce the correct formulatio...

journal_title：Trends in biotechnology

authors： Ratledge C

更新日期：1993-07-01 00:00:00

abstract：:Higher fungi with greater than 70000 species are regarded as a rich source of various natural compounds including terpenoids, the production of which represents a wide range of interest in pharmaceutical and healthcare industries. This review summarizes the current knowledge of terpenoids synthesized by higher fungi, ...

journal_title：Trends in biotechnology

authors： Xiao H,Zhong JJ

更新日期：2016-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) involves the use of a class of molecules that are activated by light, and which accumulate in, and are retained by, certain abnormal tissues. When these molecules (known as photosensitizers) are activated by light, they cause the formation of active forms of oxygen, which result in the killi...

journal_title：Trends in biotechnology

authors： Levy JG

更新日期：1995-01-01 00:00:00

abstract：:Opinions on what synthetic biology actually is range from a natural extension of genetic engineering to a new manufacturing paradigm. It offers, for the first time in the life sciences, rational design and engineering standardisation. It could address problems across a broad spectrum of human concerns, including energ...

journal_title：Trends in biotechnology

authors： Philp JC,Ritchie RJ,Allan JE

更新日期：2013-05-01 00:00:00

abstract：:Proteins found in nature have traditionally been the most frequently used biocatalysts to produce numerous natural products ranging from commodity chemicals to pharmaceuticals. Protein engineering has emerged as a powerful biotechnological toolbox in the development of metabolic engineering, particularly for the biosy...

journal_title：Trends in biotechnology

authors： Li C,Zhang R,Wang J,Wilson LM,Yan Y

更新日期：2020-07-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) technology and its application to regulatory T cells (Tregs) has garnered interest among researchers in the field of cell and gene therapy. Merging the benefits of CAR technology with Tregs offers a novel and promising therapeutic option for durable reshaping of undesired immune respons...

journal_title：Trends in biotechnology

authors： Fritsche E,Volk HD,Reinke P,Abou-El-Enein M

更新日期：2020-10-01 00:00:00

abstract：:The generation of genetically engineered (GE) foods has been raising several concerns and controversies that divide not only the general public but also the scientific community. The fear and importance of the new technology, as well as commercial interests, have supported many of the ongoing discussions. The recent i...

journal_title：Trends in biotechnology

authors： Batista R,Oliveira MM

更新日期：2009-05-01 00:00:00

abstract：:Precise control of transgene expression is pivotal to the engineering of plants with increased disease resistance. Many early attempts to boost disease resistance used constitutive overexpression of defence components but frequently this resulted in poor quality plants. It is now clear that the extensive cellular repr...

journal_title：Trends in biotechnology

authors： Gurr SJ,Rushton PJ

更新日期：2005-06-01 00:00:00

abstract：:One of the goals of synthetic biology is to build regulatory circuits that control cell behavior, for both basic research purposes and biomedical applications. The ability to build transcriptional regulatory devices depends on the availability of programmable, sequence-specific, and effective synthetic transcription f...

journal_title：Trends in biotechnology

authors： Jusiak B,Cleto S,Perez-Piñera P,Lu TK

更新日期：2016-07-01 00:00:00