Noninvasive imaging of protein-protein interactions in living organisms.


:Genomic research is expected to generate new types of complex observational data, changing the types of experiments as well as our understanding of biological processes. The investigation and definition of relationships among proteins is essential for understanding the function of each gene and the mechanisms of biological processes that specific genes are involved in. Recently, a study by Paulmurugan et al. demonstrated a tool for in vivo noninvasive imaging of protein-protein interactions and intracellular networks.


Trends Biotechnol


Trends in biotechnology


Haberkorn U,Altmann A




Has Abstract


2003-06-01 00:00:00














  • Enhanced Strategies for Antibiotic Removal from Swine Wastewater in Anaerobic Digestion.

    abstract::There is a need for techniques that ensure antibiotic removal in anaerobic digesters for robust methane production. In this article, we discuss recent strategies for enhanced antibiotic removal from swine wastewater and offer insights on anaerobic digestion (AD) process design for improved antibiotic removal. ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Zhou Q,Li X,Wu S,Zhong Y,Yang C

    更新日期:2021-01-01 00:00:00

  • Antibody separation by hydrophobic charge induction chromatography.

    abstract::Hydrophobic charge induction chromatography using 4-mercapto-ethyl-pyridine as the ligand is an effective method for the separation of antibodies from a variety of feedstocks. Antibodies are adsorbed in physiological conditions without preliminary concentration. Desorption occurs when the pH is lowered, thus inducing ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Boschetti E

    更新日期:2002-08-01 00:00:00

  • Mastitis detection: current trends and future perspectives.

    abstract::Bovine mastitis, the most significant disease of dairy herds, has huge effects on farm economics due to reduction in milk production and treatment costs. Traditionally, methods of detection have included estimation of somatic cell counts, an indication of inflammation, measurement of biomarkers associated with the ons...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Viguier C,Arora S,Gilmartin N,Welbeck K,O'Kennedy R

    更新日期:2009-08-01 00:00:00

  • The human proteomics initiative (HPI).

    abstract::The availability of the human genome sequence has enabled the exploration and exploitation of the human genome and proteome to begin. Research has now focussed on the annotation of the genome and in particular of the proteome. With expert annotation extracted from the literature by biologists as the foundation, it has...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: O'Donovan C,Apweiler R,Bairoch A

    更新日期:2001-05-01 00:00:00

  • Microbial pathogen genomes--new strategies for identifying therapeutics and vaccine targets.

    abstract::Advances in high-throughput DNA-sequencing techniques have given us the unprecedented ability to rapidly determine the nucleotide sequences of entire bacterial genomes. The application of these methods to the genomes of microbial pathogens, combined with efficient analytical tools and genome-scale approaches for study...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Smith DR

    更新日期:1996-08-01 00:00:00

  • Rational and systematic protein purification process development: the next generation.

    abstract::Current biopharmaceutical manufacturing strongly relies on using purification platform processes, offering harmonization of practices and speed-to-market. However, the ability of such processes to respond quickly to anticipated higher quality and capacity demands is under question. Here, we describe novel approaches f...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Nfor BK,Verhaert PD,van der Wielen LA,Hubbuch J,Ottens M

    更新日期:2009-12-01 00:00:00

  • Cystic fibrosis--the way forward from the gene.

    abstract::Cloning of the cystic fibrosis (CF) gene and elucidation of the physiological functions of the encoded protein is a triumph, not only for molecular biology, but also for people affected by CF. For them, not only is there now the possibility of screening for the commonest mutations, but they may also look forward to th...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Dorin JR,Porteous DJ

    更新日期:1991-02-01 00:00:00

  • High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research.

    abstract::Cellular microarrays are powerful experimental tools for high-throughput screening of large numbers of test samples. Miniaturization increases assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a wide range of assays in drug discovery, toxicology, ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Fernandes TG,Diogo MM,Clark DS,Dordick JS,Cabral JM

    更新日期:2009-06-01 00:00:00

  • Biosensors in the livestock industry: an automated ovulation prediction system for dairy cows.

    abstract::Biosensor technology can offer the livestock industry new types of monitoring and measuring devices of which the specificity, sensitivity, reproducibility, speed and ease of use exceed the current technology. Biosensors can be applied to the detection and identification of infectious diseases in livestock, contaminant...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Velasco-Garcia MN,Mottram T

    更新日期:2001-11-01 00:00:00

  • Transgenic animals as models of neurodegenerative diseases in humans.

    abstract::Neurodegenerative diseases are of major socioeconomic importance and represent an enormous challenge for the scientific and medical communities. Advances in molecular genetics during the past decade have begun to provide approaches for the establishment of animal models for these disorders using transgenic technology....

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Theuring F,Thunecke M,Kosciessa U,Turner JD

    更新日期:1997-08-01 00:00:00

  • Musculoskeletal molecular imaging: a comprehensive overview.

    abstract::Molecular imaging permits non-invasive visualization and measurement of molecular and cell biology in living subjects, thereby complementing conventional anatomical imaging. Herein, we review the emerging application of molecular imaging for the study of musculoskeletal biology. Utilizing mainly bioluminescence and fl...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Reumann MK,Weiser MC,Mayer-Kuckuk P

    更新日期:2010-02-01 00:00:00

  • Dynamic transcriptome of mice.

    abstract::Life science in the 21st century is developing rapidly through the structural analysis of biomolecules, the completion of the human genome sequence and the analysis of transcriptomes. The mouse transcriptome has been comprehensively analyzed using a gene discovery approach to collect full-length cDNA (FL-cDNA) clones....

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Hayashizaki Y,Kanamori M

    更新日期:2004-04-01 00:00:00

  • RNAi/CRISPR Screens: from a Pool to a Valid Hit.

    abstract::High-throughput genetic screens interfering with gene expression are invaluable tools to identify gene function and phenotype-to-genotype interactions. Implementing such screens in the laboratory is challenging, and the choice between currently available technologies based on RNAi and CRISPR/Cas9 (CRISPR-associated pr...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Schuster A,Erasimus H,Fritah S,Nazarov PV,van Dyck E,Niclou SP,Golebiewska A

    更新日期:2019-01-01 00:00:00

  • The Emerging Role of Gas Plasma in Oncotherapy.

    abstract::Atmospheric pressure gas plasmas are emerging as a promising treatment in cancer that can supplement the existing set of treatment modalities and, when combined with other therapies, enhance their selectivity and efficacy against resistant cancers. With further optimisation in production and administration of plasma t...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Dai X,Bazaka K,Richard DJ,Thompson ERW,Ostrikov KK

    更新日期:2018-11-01 00:00:00

  • Malaria transmission-blocking vaccines.

    abstract::Antibodies to surface proteins of the sexual stages of Plasmodium falciparum block completely the transmission of these malaria parasites. Transmission-blocking vaccines therefore represent a powerful and novel approach to controlling the spread of this lethal disease. ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Kaslow DC,Bathurst IC,Barr PJ

    更新日期:1992-11-01 00:00:00

  • Rethinking production of Taxol® (paclitaxel) using endophyte biotechnology.

    abstract::Taxol® (generic name paclitaxel) represents one of the most clinically valuable natural products known to mankind in the recent past. More than two decades have elapsed since the notable discovery of the first Taxol®-producing endophytic fungus, which was followed by a plethora of reports on other endophytes possessin...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Kusari S,Singh S,Jayabaskaran C

    更新日期:2014-06-01 00:00:00

  • Bioelectrochemical Power-to-Gas: State of the Art and Future Perspectives.

    abstract::Bioelectrochemical power-to-gas (BEP2G) is considered a potentially convenient way of storing renewable surplus electricity in the form of methane. In methane-producing bioelectrochemical systems (BESs), carbon dioxide and electrical energy are converted into methane, using electrodes that supply either electrons or h...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Geppert F,Liu D,van Eerten-Jansen M,Weidner E,Buisman C,Ter Heijne A

    更新日期:2016-11-01 00:00:00

  • Mechatronics design principles for biotechnology product development.

    abstract::Traditionally, biotechnology design has focused on the manufacture of chemicals and biologics. Still, a majority of biotechnology products that appear on the market today is the result of mechanical-electric (mechatronic) construction. For these, the biological components play decisive roles in the design solution; th...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Mandenius CF,Björkman M

    更新日期:2010-05-01 00:00:00

  • Protein-protein docking: is the glass half-full or half-empty?

    abstract::Are current docking methods capable of building complexes from putative component protein structures? Results of recent computational studies, including those of the CAPRI (Critical Assessment of Protein Interactions) competition, were used to determine the key properties for successful docking and introduce a classif...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Vajda S,Camacho CJ

    更新日期:2004-03-01 00:00:00

  • Four-dimensional imaging: the exploration of space and time.

    abstract::The process of studying dynamic three-dimensional samples has a long history in biological research. Recent advances in hardware and software have made it easier to visualise and record interior detail from multiple focal planes of three-dimensional samples as they change over time (four-dimensional imaging). Once cap...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Thomas CF,White JG

    更新日期:1998-04-01 00:00:00

  • Soluble receptors for IL-1 and IL-4: biological activity and therapeutic potential.

    abstract::Cytokine research has yielded a range of products which have now reached the stage of clinical trials and a plethora of novel therapeutics may be expected. Recently, cytokine receptors have also become an area of intensive research. Preliminary results indicate that recombinant soluble receptors can interfere with the...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Maliszewski CR,Fanslow WC

    更新日期:1990-11-01 00:00:00

  • Rapid prototyping as a tool for manufacturing bioartificial livers.

    abstract::Rapid prototyping (RP) technologies are a set of manufacturing processes that can produce very complex structures directly from computer-aided design models without structure-specific tools or knowledge. These technologies might eventually enable the manufacture of human livers to create functional substitutes for tre...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Wang X,Yan Y,Zhang R

    更新日期:2007-11-01 00:00:00

  • Biosensing with cell phones.

    abstract::Continued progress in cell-phone devices has made them powerful mobile computers, equipped with sophisticated, permanent physical sensors embedded as the default configuration. By contrast, the incorporation of permanent biosensors in cell-phone units has been prevented by the multivocal nature of the stimuli and the ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Preechaburana P,Suska A,Filippini D

    更新日期:2014-07-01 00:00:00

  • Genetic engineering of wheat--current challenges and opportunities.

    abstract::Wheat is one of the major staple food crops grown worldwide; however, productivity in cereal crops has not kept pace with the world population growth. A significant increase in wheat production (>40% by 2020) is needed simply to keep up with the growing demand. This increase is unlikely to be achieved by conventional ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Bhalla PL

    更新日期:2006-07-01 00:00:00

  • The evolution of structural databases.

    abstract::Starting with the Protein Data Bank (PDB) as a common ancestor, the evolution of structural databases has been driven by the rapprochement of the structural world and the practical applications. The result is an impressive number of secondary structural databases that is welcomed by structural biologists and bioinform...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Carugo O,Pongor S

    更新日期:2002-12-01 00:00:00

  • Transgenic plants as vaccine production systems.

    abstract::Transgenic plants that express foreign proteins with industrial or pharmaceutical value represent an economical alternative to fermentation-based production systems. Specific vaccines have been produced in plants as a result of the transient or stable expression of foreign genes. It has recently been shown that genes ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Mason HS,Arntzen CJ

    更新日期:1995-09-01 00:00:00

  • Biomimetic approaches to protein and gene delivery for tissue regeneration.

    abstract::Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues. Many synthetic or natural biomaterials have been developed for this purpose and are used to deliver wound therapeutics in a controlled manner that prevents unwan...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Andreadis ST,Geer DJ

    更新日期:2006-07-01 00:00:00

  • Artificial molecular sieves and filters: a new paradigm for biomolecule separation.

    abstract::Patterned regular sieves and filters with comparable molecular dimensions hold great promise as an alternative to conventional polymeric gels and fibrous membranes to improve biomolecule separation. Recent developments of microfabricated nanofluidic sieves and filters have demonstrated superior performance for both an...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Fu J,Mao P,Han J

    更新日期:2008-06-01 00:00:00

  • Facts and fiction of genetically engineered food.

    abstract::The generation of genetically engineered (GE) foods has been raising several concerns and controversies that divide not only the general public but also the scientific community. The fear and importance of the new technology, as well as commercial interests, have supported many of the ongoing discussions. The recent i...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Batista R,Oliveira MM

    更新日期:2009-05-01 00:00:00

  • Mutasynthesis - uniting chemistry and genetics for drug discovery.

    abstract::Mutasynthesis couples the power of chemical synthesis with molecular biology to generate derivatives of medicinally valuable, natural products. Recently, this technique has been exploited by Cambridge-based biotech company Biotica Technology Ltd, and their collaborators, to generate promising new variants of the polyk...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Weissman KJ

    更新日期:2007-04-01 00:00:00