Abstract：
:Type 1 Diabetes (T1D) is an autoimmune disease resulting from the destruction of pancreatic insulin-producing beta cells that most frequently occurs in genetically predisposed children. Recent observations illustrating the regenerative capability of the endocrine pancreas in addition to advances in stem cell and gene therapy technologies enable the exploration of alternatives to allogeneic islet transplantation. Living-cell-mediated approaches can abrogate autoimmunity and the consequent destruction of beta cells without the need for immunosuppressive drugs. Such approaches can be used as a foundation for new protocols that more easily translate to the clinical setting. The twin goals of controlling autoimmune disease and promoting stable regeneration of insulin-producing beta cells should be considered the cornerstones of the successful development of a cure for this chronic disease.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Pasquali L,Fan Y,Trucco M,Ringquist Sdoi
10.1016/j.tibtech.2006.08.007subject
Has Abstractpub_date
2006-11-01 00:00:00pages
516-22issue
11eissn
0167-7799issn
1879-3096pii
S0167-7799(06)00214-9journal_volume
24pub_type
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