Abstract：
:Spheroids provide a 3D environment with intensive cell-cell contacts. As a result of their excellent regenerative properties and rapid progress in their high-throughput production, spheroids are increasingly suggested as building blocks for tissue engineering. In this review, we focus on innovative biotechnological approaches that increase the quality of spheroids for this specific type of application. These include in particular the fabrication of coculture spheroids, mimicking the complex morphology and physiological tasks of natural tissues. In vitro preconditioning under different culture conditions and incorporation of biomaterials improve the function of spheroids and their directed fusion into macrotissues of desired shapes. The continuous development of these sophisticated approaches may markedly contribute to a broad implementation of spheroid-based tissue engineering in future regenerative medicine.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Laschke MW,Menger MDdoi
10.1016/j.tibtech.2016.08.004subject
Has Abstractpub_date
2017-02-01 00:00:00pages
133-144issue
2eissn
0167-7799issn
1879-3096pii
S0167-7799(16)30129-9journal_volume
35pub_type
杂志文章,评审abstract：:Animals exploit soft structures to move effectively in complex natural environments. These capabilities have inspired robotic engineers to incorporate soft technologies into their designs. The goal is to endow robots with new, bioinspired capabilities that permit adaptive, flexible interactions with unpredictable envi...
journal_title：Trends in biotechnology
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abstract：:Bacteriophages encode many distinct proteins for the successful infection of a bacterial host. Each protein plays a specific role in the phage replication cycle, from host recognition, through takeover of the host machinery, and up to cell lysis for progeny release. As the roles of these proteins are being revealed, m...
journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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更新日期：2016-11-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
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journal_title：Trends in biotechnology
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更新日期：2019-02-01 00:00:00
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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doi：10.1016/j.tibtech.2005.12.007
更新日期：2006-02-01 00:00:00
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
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abstract：:Carotenoids are one of the most diverse classes of natural compounds. Plant carotenoids are composed of a C40 isoprenoid skeleton with or without epoxy, hydroxy and keto groups. They have fundamental roles in human nutrition as antioxidants and vitamin A precursors and their consumption is increasingly associated with...
journal_title：Trends in biotechnology
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doi：10.1016/j.tibtech.2007.12.003
更新日期：2008-03-01 00:00:00
