Abstract:
:Taxol® (generic name paclitaxel) represents one of the most clinically valuable natural products known to mankind in the recent past. More than two decades have elapsed since the notable discovery of the first Taxol®-producing endophytic fungus, which was followed by a plethora of reports on other endophytes possessing similar biosynthetic potential. However, industrial-scale Taxol® production using fungal endophytes, although seemingly promising, has not seen the light of the day. In this opinion article, we embark on the current state of knowledge on Taxol® biosynthesis focusing on the chemical ecology of its producers, and ask whether it is actually possible to produce Taxol® using endophyte biotechnology. The key problems that have prevented the exploitation of potent endophytic fungi by industrial bioprocesses for sustained production of Taxol® are discussed.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Kusari S,Singh S,Jayabaskaran Cdoi
10.1016/j.tibtech.2014.03.011subject
Has Abstractpub_date
2014-06-01 00:00:00pages
304-11issue
6eissn
0167-7799issn
1879-3096pii
S0167-7799(14)00064-Xjournal_volume
32pub_type
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