Rethinking production of Taxol® (paclitaxel) using endophyte biotechnology.

Abstract:

:Taxol® (generic name paclitaxel) represents one of the most clinically valuable natural products known to mankind in the recent past. More than two decades have elapsed since the notable discovery of the first Taxol®-producing endophytic fungus, which was followed by a plethora of reports on other endophytes possessing similar biosynthetic potential. However, industrial-scale Taxol® production using fungal endophytes, although seemingly promising, has not seen the light of the day. In this opinion article, we embark on the current state of knowledge on Taxol® biosynthesis focusing on the chemical ecology of its producers, and ask whether it is actually possible to produce Taxol® using endophyte biotechnology. The key problems that have prevented the exploitation of potent endophytic fungi by industrial bioprocesses for sustained production of Taxol® are discussed.

journal_name

Trends Biotechnol

journal_title

Trends in biotechnology

authors

Kusari S,Singh S,Jayabaskaran C

doi

10.1016/j.tibtech.2014.03.011

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

304-11

issue

6

eissn

0167-7799

issn

1879-3096

pii

S0167-7799(14)00064-X

journal_volume

32

pub_type

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