Synthetic Biology Tools to Engineer Microbial Communities for Biotechnology.

abstract：:Advances in our capacity to design and use novel strategies for achieving inducible gene expression will improve our ability to define gene function. An extremely efficient system designed by nature -- that of the regulatable phytochrome system in plants -- has provided the basis for developing a novel inducible gene ...

journal_title：Trends in biotechnology

authors： Keyes WM,Mills AA

更新日期：2003-02-01 00:00:00

abstract：:Along with the development of metabolic engineering and synthetic biology tools, various microbes are being used to produce aromatic chemicals. In microbes, aromatics are mainly produced via a common important precursor, chorismate, in the shikimate pathway. Natural or non-natural aromatics have been produced by engin...

journal_title：Trends in biotechnology

authors： Noda S,Kondo A

更新日期：2017-08-01 00:00:00

abstract：:Rising global demand for meat will result in increased environmental pollution, energy consumption, and animal suffering. Cultured meat, produced in an animal-cell cultivation process, is a technically feasible alternative lacking these disadvantages, provided that an animal-component-free growth medium can be develop...

journal_title：Trends in biotechnology

authors： van der Weele C,Tramper J

更新日期：2014-06-01 00:00:00

abstract：:The baculovirus expression system has been used extensively for the expression of recombinant proteins in insect cells. Recently, recombinant baculovirus vectors engineered to contain mammalian cell-active promoter elements, have been used successfully for transient and stable gene delivery in a broad spectrum of prim...

journal_title：Trends in biotechnology

authors： Kost TA,Condreay JP

更新日期：2002-04-01 00:00:00

abstract：:A recent publication has reported the fabrication of a new microbial culture device containing an array of unprecedented density - a million growth chambers. This micro-Petri chip should impact on various fields, including biotechnology, ecology, food microbiology and drug development, by enabling high-throughput scre...

journal_title：Trends in biotechnology

authors： Gefen O,Balaban NQ

更新日期：2008-07-01 00:00:00

abstract：:The glycosylation profile of a recombinant glycoprotein can not only significantly affect its therapeutic profile, but is also extremely sensitive to cell-culture and purification conditions. To define glycosylation patterns and to ensure consistency of recombinant glycoproteins among different preparations requires h...

journal_title：Trends in biotechnology

authors： Parekh RB,Patel TP

更新日期：1992-08-01 00:00:00

abstract：:Modern biocatalysis is developing new and precise tools to improve a wide range of production processes, which reduce energy and raw material consumption and generate less waste and toxic side-products. Biocatalysis is also achieving new advances in environmental fields, from enzymatic bioremediation to the synthesis ...

journal_title：Trends in biotechnology

authors： Alcalde M,Ferrer M,Plou FJ,Ballesteros A

更新日期：2006-06-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease resulting from the destruction of pancreatic insulin-producing beta cells that most frequently occurs in genetically predisposed children. Recent observations illustrating the regenerative capability of the endocrine pancreas in addition to advances in stem cell and gene ...

journal_title：Trends in biotechnology

authors： Pasquali L,Fan Y,Trucco M,Ringquist S

更新日期：2006-11-01 00:00:00

abstract：:Hydrogels are 3D hydrophilic polymer networks that absorb and hold huge amounts of water. Although hydrogels have traditionally been synthesized using chemical and physical methods, rapid developments in enzyme technology that, like chemical-based methods, enable the formation of stable covalent bonds are fast emergin...

journal_title：Trends in biotechnology

authors： Guebitz GM,Nyanhongo GS

更新日期：2018-10-01 00:00:00

abstract：:Vascularisation is key to developing large transplantable tissue constructs capable of providing therapeutic benefits. The vascularised tissue engineering chamber originates from surgical concepts in tissue prefabrication and microsurgery. It serves as an in vivo bioreactor in the form of a closed, protected space sur...

journal_title：Trends in biotechnology

authors： Yap KK,Yeoh GC,Morrison WA,Mitchell GM

更新日期：2018-10-01 00:00:00

abstract：:The ability to detect single-base changes is of fundamental importance in molecular genetics. This is particularly true in human genetics, where interest in linking mutations of identified genes to particular disease phenotypes is most intense, and where a demand exists for clinical diagnosis of defined mutations. In ...

journal_title：Trends in biotechnology

authors： Prosser J

更新日期：1993-06-01 00:00:00

abstract：:Although many microorganisms have been used for the bioindustrial generation of valuable metabolites, the productive potential of cyanobacterial species has remained largely unexplored. Cyanobacteria possess several advantages as organisms for bioindustrial processes, including simple input requirements, tolerance of ...

journal_title：Trends in biotechnology

authors： Ducat DC,Way JC,Silver PA

更新日期：2011-02-01 00:00:00

abstract：:Process analytical technology (PAT) for the manufacture of monoclonal antibodies (mAbs) is defined by an integrated set of advanced and automated methods that analyze the compositions and biophysical properties of cell culture fluids, cell-free product streams, and biotherapeutic molecules that are ultimately formulat...

journal_title：Trends in biotechnology

authors： Maruthamuthu MK,Rudge SR,Ardekani AM,Ladisch MR,Verma MS

更新日期：2020-10-01 00:00:00

abstract：:Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) components in an important interface whose correct functioning is crit...

journal_title：Trends in biotechnology

authors： Potjewyd G,Moxon S,Wang T,Domingos M,Hooper NM

更新日期：2018-04-01 00:00:00

abstract：:Attempts through somatic cell nuclear transfer to expand wild populations that have shrunk to critical numbers is a logical extension of the successful cloning of mammals. However, although the first mammal was cloned 10 years ago, nuclear reprogramming remains phenomenological, with abnormal gene expression and epige...

journal_title：Trends in biotechnology

authors： Loi P,Galli C,Ptak G

更新日期：2007-05-01 00:00:00

abstract：:Integrated biorefineries have the potential to contribute towards sustainable production of transportation fuels, energy, and chemicals. However, because there are currently no commercial biorefining plants in operation, it is not clear how sustainable they really are. This paper sets out to examine key issues associa...

journal_title：Trends in biotechnology

authors： Azapagic A

更新日期：2014-01-01 00:00:00

abstract：:Wheat is one of the major staple food crops grown worldwide; however, productivity in cereal crops has not kept pace with the world population growth. A significant increase in wheat production (>40% by 2020) is needed simply to keep up with the growing demand. This increase is unlikely to be achieved by conventional ...

journal_title：Trends in biotechnology

authors： Bhalla PL

更新日期：2006-07-01 00:00:00

abstract：:Cultured mammalian cells are the main workhorses for producing biologics. The performance of these cell culture processes, in terms of both productivity and product quality attributes, is significantly influenced by cellular metabolism. Glucose is the major carbon source for cellular biosynthesis and energy generation...

journal_title：Trends in biotechnology

authors： Mulukutla BC,Yongky A,Le T,Mashek DG,Hu WS

更新日期：2016-08-01 00:00:00

abstract：:Biosensor technology can offer the livestock industry new types of monitoring and measuring devices of which the specificity, sensitivity, reproducibility, speed and ease of use exceed the current technology. Biosensors can be applied to the detection and identification of infectious diseases in livestock, contaminant...

journal_title：Trends in biotechnology

authors： Velasco-Garcia MN,Mottram T

更新日期：2001-11-01 00:00:00

abstract：:The use of antibodies or antibody fragments for targeting tumors (either for tumor imaging or as carriers for drugs or toxins), has encountered problems of clearance, and non-specific or inefficient binding in clinical trials. A novel approach, linking two antibody variable fragments (Fvs), with a short peptide to gen...

journal_title：Trends in biotechnology

authors： Bird RE,Walker BW

更新日期：1991-04-01 00:00:00

abstract：:In Europe, in light of ethical, political and commercial pressure, every effort should be made to replace animals with alternatives (e.g. in vitro models), to reduce the number of animals used in experiments to a minimum and to refine current testing strategies in a way that ensures animals undergo minimum pain and di...

journal_title：Trends in biotechnology

authors： Kroeger M

更新日期：2006-08-01 00:00:00

abstract：:Transgenic plants that express foreign proteins with industrial or pharmaceutical value represent an economical alternative to fermentation-based production systems. Specific vaccines have been produced in plants as a result of the transient or stable expression of foreign genes. It has recently been shown that genes ...

journal_title：Trends in biotechnology

authors： Mason HS,Arntzen CJ

更新日期：1995-09-01 00:00:00

abstract：:Recent advances in the extraction and purification of decellularized extracellular matrix (dECM) obtained from healthy or malignant tissues open new avenues for engineering physiomimetic 3D in vitro tumor models, which closely recapitulate key biomolecular hallmarks and the dynamic cancer cell-ECM interactions in the ...

journal_title：Trends in biotechnology

authors： Ferreira LP,Gaspar VM,Mano JF

更新日期：2020-12-01 00:00:00

abstract：:Targeting apoptotic cell death pathways provides wide-ranging opportunities for the discovery and development of novel drugs. Some targeted therapies that selectively induce apoptosis in cancer cells are already marketed, and numerous pro-apoptotic drugs for treating cancer are currently being developed. The anti-apop...

journal_title：Trends in biotechnology

authors： Alam JJ

更新日期：2003-11-01 00:00:00

abstract：:Accurate diagnosis and prognosis is essential for cancer management but is subject to sampling and inter-observer error. In a recent study, Baker et al. compared Fourier transform infrared (FTIR) microspectroscopy with histological pathology to evaluate prostate tissue for disease severity. The authors found that bioc...

journal_title：Trends in biotechnology

authors： Mackanos MA,Contag CH

更新日期：2009-12-01 00:00:00

abstract：:Atmospheric pressure gas plasmas are emerging as a promising treatment in cancer that can supplement the existing set of treatment modalities and, when combined with other therapies, enhance their selectivity and efficacy against resistant cancers. With further optimisation in production and administration of plasma t...

journal_title：Trends in biotechnology

authors： Dai X,Bazaka K,Richard DJ,Thompson ERW,Ostrikov KK

更新日期：2018-11-01 00:00:00

abstract：:The existence of a medicinal 'biotech revolution' has been widely accepted and promoted by academics, consultants, industry and government. This has generated expectations about significant improvements in the drug discovery process, healthcare and economic development that influence a considerable amount of policy-ma...

journal_title：Trends in biotechnology

authors： Nightingale P,Martin P

更新日期：2004-11-01 00:00:00

abstract：:Gastrointestinal cancers rank second in overall cancer-related deaths. Carotenoids, sulfated polysaccharides, and polyunsaturated fatty acids (PUFAs) from microalgae exhibit cancer chemopreventive features at different stages of carcinogenesis. For instance, sulfated polysaccharides bear a prophylactic potential via b...

journal_title：Trends in biotechnology

authors： Amaro HM,Barros R,Guedes AC,Sousa-Pinto I,Malcata FX

更新日期：2013-02-01 00:00:00

abstract：:The demands on drug discovery organizations have increased dramatically in recent years, partly because of the need to identify novel targets that are both relevant to disease and chemically tractable. This is leading to an industrial approach to traditional biology and chemistry, inspired in part by the revolution in...

journal_title：Trends in biotechnology

authors： Dean PM,Zanders ED,Bailey DS

更新日期：2001-08-01 00:00:00

abstract：:Genomic research is expected to generate new types of complex observational data, changing the types of experiments as well as our understanding of biological processes. The investigation and definition of relationships among proteins is essential for understanding the function of each gene and the mechanisms of biolo...

journal_title：Trends in biotechnology

authors： Haberkorn U,Altmann A

更新日期：2003-06-01 00:00:00