Synthetic Biology Tools to Engineer Microbial Communities for Biotechnology.

Abstract:

:Microbial consortia have been used in biotechnology processes, including fermentation, waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly engineering microbial consortia for diverse applications, including the bioproduction of medicines, biofuels, and biomaterials from inexpensive carbon sources. An improved understanding of natural microbial ecosystems, and the development of new tools to construct synthetic consortia and program their behaviors, will vastly expand the functions that can be performed by communities of interacting microorganisms. Here, we review recent advancements in synthetic biology tools and approaches to engineer synthetic microbial consortia, discuss ongoing and emerging efforts to apply consortia for various biotechnological applications, and suggest future applications.

journal_name

Trends Biotechnol

journal_title

Trends in biotechnology

authors

McCarty NS,Ledesma-Amaro R

doi

10.1016/j.tibtech.2018.11.002

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

181-197

issue

2

eissn

0167-7799

issn

1879-3096

pii

S0167-7799(18)30312-3

journal_volume

37

pub_type

杂志文章,评审
  • Taking your breath away: metabolomics breathes life in to personalized medicine.

    abstract::Breath-based metabolomics (breathomics) is an exciting developing area of biotechnology that centers on the capture, identification, and quantification of volatile organic compound (VOC) patterns in human breath and their utilization as tools in the diagnosis of a broad spectrum of medical problems. With the age of pe...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2014.08.003

    authors: Rattray NJ,Hamrang Z,Trivedi DK,Goodacre R,Fowler SJ

    更新日期:2014-10-01 00:00:00

  • Bioelectrochemical Power-to-Gas: State of the Art and Future Perspectives.

    abstract::Bioelectrochemical power-to-gas (BEP2G) is considered a potentially convenient way of storing renewable surplus electricity in the form of methane. In methane-producing bioelectrochemical systems (BESs), carbon dioxide and electrical energy are converted into methane, using electrodes that supply either electrons or h...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2016.08.010

    authors: Geppert F,Liu D,van Eerten-Jansen M,Weidner E,Buisman C,Ter Heijne A

    更新日期:2016-11-01 00:00:00

  • Harnessing Prefrontal Cognitive Signals for Brain-Machine Interfaces.

    abstract::Brain-machine interfaces (BMIs) enable humans to interact with devices by modulating their brain signals. Despite impressive technological advancements, several obstacles remain. The most commonly used BMI control signals are derived from the brain areas involved in primary sensory- or motor-related processing. Howeve...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2017.03.008

    authors: Min BK,Chavarriaga R,Millán JDR

    更新日期:2017-07-01 00:00:00

  • Biocatalytic transformations in ionic liquids.

    abstract::Room temperature ionic liquids are non-volatile, thermally stable and highly polar; they are also moderately hydrophilic solvents. Here, we discuss their use as reaction media for biocatalysis. Enzymes of widely diverging types are catalytically active in ionic liquids or aqueous biphasic ionic liquid systems. Lipases...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/S0167-7799(03)00008-8

    authors: van Rantwijk F,Madeira Lau R,Sheldon RA

    更新日期:2003-03-01 00:00:00

  • In vivo-applied functional RNAs as tools in proteomics and genomics research.

    abstract::Non-natural, functional RNA molecules, such as short interfering (si) RNAs, aptazymes, maxizymes and intramers, allow modulation of gene function at the mRNA or protein level. This review discusses recent advances made in the expression and application of these functional RNAs and illustrates how engineered, intracell...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/s0167-7799(02)02063-2

    authors: Famulok M,Verma S

    更新日期:2002-11-01 00:00:00

  • Microbial pathogen genomes--new strategies for identifying therapeutics and vaccine targets.

    abstract::Advances in high-throughput DNA-sequencing techniques have given us the unprecedented ability to rapidly determine the nucleotide sequences of entire bacterial genomes. The application of these methods to the genomes of microbial pathogens, combined with efficient analytical tools and genome-scale approaches for study...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/0167-7799(96)10038-X

    authors: Smith DR

    更新日期:1996-08-01 00:00:00

  • Biomaterials aspects of porous microcarriers for animal cell culture.

    abstract::Porous microcarriers are new support materials with important advantages in both industrial cell-culture processes and the culture of cells of medical importance. Porous microcarriers are now commercially available with internal architecture and surface chemistry suitable for culture of both anchorage-dependent and an...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/0167-7799(90)90154-p

    authors: Cahn F

    更新日期:1990-05-01 00:00:00

  • Adding synchrotron radiation to infrared microspectroscopy: what's new in biomedical applications?

    abstract::Infrared spectroscopy and microscopy have heralded a period of rapid advances in tissue and cellular characterization during the past decade. However, vibrational spectroscopy is still an analytical tool that is neither familiar nor understood in the medical environment. For many years this field has been mainly drive...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2006.11.002

    authors: Dumas P,Sockalingum GD,Sulé-Suso J

    更新日期:2007-01-01 00:00:00

  • Industrial-scale, genomics-based drug design and discovery.

    abstract::The demands on drug discovery organizations have increased dramatically in recent years, partly because of the need to identify novel targets that are both relevant to disease and chemically tractable. This is leading to an industrial approach to traditional biology and chemistry, inspired in part by the revolution in...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/s0167-7799(01)01696-1

    authors: Dean PM,Zanders ED,Bailey DS

    更新日期:2001-08-01 00:00:00

  • Potential of siderophore-producing bacteria for improving heavy metal phytoextraction.

    abstract::Phytoremediation holds promise for in situ treatment of heavy metal contaminated soils. Recently, the benefits of combining siderophore-producing bacteria (SPB) with plants for metal removal from contaminated soils have been demonstrated. Metal-resistant SPB play an important role in the successful survival and growth...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2009.12.002

    authors: Rajkumar M,Ae N,Prasad MN,Freitas H

    更新日期:2010-03-01 00:00:00

  • Platelet-Derived Products in Veterinary Medicine: A New Trend or an Effective Therapy?

    abstract::Platelet-derived products (PDPs) have gained popularity, mainly due to their high concentrations of bioactive molecules such as growth factors and cytokines, which play important roles in tissue healing and regeneration. PDPs are obtained through minimally invasive procedures and their therapeutic effect has been wide...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2020.07.011

    authors: Soares CS,Babo PS,Reis RL,Carvalho PP,Gomes ME

    更新日期:2020-08-28 00:00:00

  • Isolating ligands specific for human vasculature using in vivo phage selection.

    abstract::The endothelium lining blood vessels expresses molecules that are restricted in their expression to a particular tissue or organ. These molecules are attractive targets for therapy and diagnosis because they allow agents to be delivered specifically to the blood vessels supplying the desired tissue. However, it is dif...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/S0167-7799(03)00079-9

    authors: George AJ,Lee L,Pitzalis C

    更新日期:2003-05-01 00:00:00

  • Biosensors based on binding-modulated donor-acceptor distances.

    abstract::The promising recognition characteristics exhibited by biomolecules have caused significant interest in biomolecule-based sensor strategies. Here we review several emerging biosensor designs that use modulated electron or energy transfer to a bio-specific ligand as the signaling mechanism. The efficiencies of both ele...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2005.02.005

    authors: Fan C,Plaxco KW,Heeger AJ

    更新日期:2005-04-01 00:00:00

  • Cultured meat: every village its own factory?

    abstract::Rising global demand for meat will result in increased environmental pollution, energy consumption, and animal suffering. Cultured meat, produced in an animal-cell cultivation process, is a technically feasible alternative lacking these disadvantages, provided that an animal-component-free growth medium can be develop...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2014.04.009

    authors: van der Weele C,Tramper J

    更新日期:2014-06-01 00:00:00

  • Enhanced Strategies for Antibiotic Removal from Swine Wastewater in Anaerobic Digestion.

    abstract::There is a need for techniques that ensure antibiotic removal in anaerobic digesters for robust methane production. In this article, we discuss recent strategies for enhanced antibiotic removal from swine wastewater and offer insights on anaerobic digestion (AD) process design for improved antibiotic removal. ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2020.07.002

    authors: Zhou Q,Li X,Wu S,Zhong Y,Yang C

    更新日期:2021-01-01 00:00:00

  • Two-phase partitioning bioreactors: a new technology platform for destroying xenobiotics.

    abstract::Toxic organic compounds (xenobiotics) pose serious environmental and health risks worldwide. Biological treatment of these materials is severely constrained by their toxic and inhibitory nature and great care is required with respect to the rate at which they are provided to cells. The use of a second, distinct, organ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/s0167-7799(01)01789-9

    authors: Daugulis AJ

    更新日期:2001-11-01 00:00:00

  • Phaeodactylum tricornutum: A Diatom Cell Factory.

    abstract::A switch from a petroleum-based to a biobased economy requires the capacity to produce both high-value low-volume and low-value high-volume products. Recent evidence supports the development of microalgae-based microbial cell factories with the objective of establishing environmentally sustainable manufacturing soluti...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2019.12.023

    authors: Butler T,Kapoore RV,Vaidyanathan S

    更新日期:2020-06-01 00:00:00

  • Against the grain: safeguarding rice from rice blast disease.

    abstract::Rice is the staple diet of more than three billion people. Yields must double over the next 40 years if we are to sustain the nutritional needs of the ever-expanding global population. Between 10% and 30% of the annual rice harvest is lost due to infection by the rice blast fungus Magnaporthe oryzae. Evaluation of gen...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2008.12.002

    authors: Skamnioti P,Gurr SJ

    更新日期:2009-03-01 00:00:00

  • Biosensors in the livestock industry: an automated ovulation prediction system for dairy cows.

    abstract::Biosensor technology can offer the livestock industry new types of monitoring and measuring devices of which the specificity, sensitivity, reproducibility, speed and ease of use exceed the current technology. Biosensors can be applied to the detection and identification of infectious diseases in livestock, contaminant...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/s0167-7799(01)01841-8

    authors: Velasco-Garcia MN,Mottram T

    更新日期:2001-11-01 00:00:00

  • Synthetic biology, the bioeconomy, and a societal quandary.

    abstract::Opinions on what synthetic biology actually is range from a natural extension of genetic engineering to a new manufacturing paradigm. It offers, for the first time in the life sciences, rational design and engineering standardisation. It could address problems across a broad spectrum of human concerns, including energ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2013.01.011

    authors: Philp JC,Ritchie RJ,Allan JE

    更新日期:2013-05-01 00:00:00

  • Optimizing scale-up fermentation processes.

    abstract::There are many aims associated with the optimization of fermentation processes. Optimization is expected to increase the yield of the final product but the process must be compliant with good manufacturing practices, the available equipment and the expected final scale of operation. Dealing with genetically modified m...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/s0167-7799(02)01913-3

    authors: Thiry M,Cingolani D

    更新日期:2002-03-01 00:00:00

  • Drugs against superbugs: private lessons from bacteriophages.

    abstract::Bacterial genomics has provided a plethora of potential targets for antibacterial drug discovery, however, success in the hunt for new antibiotics will hinge on selecting targets with the highest potential. A recent paper by Liu and coworkers describes a new approach to target selection that uncovers strategies used b...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2004.07.004

    authors: Brown ED

    更新日期:2004-09-01 00:00:00

  • Information content of volume holographic imaging.

    abstract::We discuss the general properties of optical imaging in three-dimensional object domains from an information-theoretic standpoint, expressing system performance in terms of imaging mutual information (IMI). We use IMI to characterize volume holographic imaging, a new optical imaging method with depth discrimination ca...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/s0167-7799(01)01743-7

    authors: Barbastathis G,Sinha A

    更新日期:2001-10-01 00:00:00

  • Non-invasive wearable electrochemical sensors: a review.

    abstract::Wearable sensors have garnered considerable recent interest owing to their tremendous promise for a plethora of applications. Yet the absence of reliable non-invasive chemical sensors has greatly hindered progress in the area of on-body sensing. Electrochemical sensors offer considerable promise as wearable chemical s...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2014.04.005

    authors: Bandodkar AJ,Wang J

    更新日期:2014-07-01 00:00:00

  • Non-GMO genetically edited crop plants.

    abstract::Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2015.04.002

    authors: Kanchiswamy CN,Malnoy M,Velasco R,Kim JS,Viola R

    更新日期:2015-09-01 00:00:00

  • Factoring Ecological, Societal, and Economic Considerations into Inoculant Development.

    abstract::There are many paths toward effective microbial inoculants for agriculture. Considering what is practical for the present day technological and farming landscape should not limit our creativity in developing innovative technologies. However, factors including production costs, practicality of implementation, and techn...

    journal_title:Trends in biotechnology

    pub_type: 评论,信件

    doi:10.1016/j.tibtech.2019.02.009

    authors: Bell TH,Kaminsky LM,Gugino BK,Carlson JE,Malik RJ,Hockett KL,Trexler RV

    更新日期:2019-06-01 00:00:00

  • Malaria transmission-blocking vaccines.

    abstract::Antibodies to surface proteins of the sexual stages of Plasmodium falciparum block completely the transmission of these malaria parasites. Transmission-blocking vaccines therefore represent a powerful and novel approach to controlling the spread of this lethal disease. ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/0167-7799(92)90280-9

    authors: Kaslow DC,Bathurst IC,Barr PJ

    更新日期:1992-11-01 00:00:00

  • A giant step towards artificial life?

    abstract::Step by step, the components of an artificial form of cellular life are being assembled by researchers. Lipid vesicles the size of small bacteria can be prepared and under certain conditions are able to grow and divide, then grow again. Polymerase enzymes encapsulated in the vesicles can synthesize RNA from externally...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2005.05.008

    authors: Deamer D

    更新日期:2005-07-01 00:00:00

  • Photodynamic therapy.

    abstract::Photodynamic therapy (PDT) involves the use of a class of molecules that are activated by light, and which accumulate in, and are retained by, certain abnormal tissues. When these molecules (known as photosensitizers) are activated by light, they cause the formation of active forms of oxygen, which result in the killi...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/S0167-7799(00)88895-2

    authors: Levy JG

    更新日期:1995-01-01 00:00:00

  • Quality assurance mechanisms for the unregulated research environment.

    abstract::Discussions on research quality and reproducibility are appearing in the pages of scientific journals with heightened significance and gaining media attention. Many institutions have developed guidelines to address the topic of quality in basic research, but questions remain about how best to implement and monitor com...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2013.06.007

    authors: Riedl DH,Dunn MK

    更新日期:2013-10-01 00:00:00