Abstract:
:Here, we discuss recent advances in the development of artificial red blood cell (RBC) substitutes, illustrating lessons learned from initial attempts using perfluorocarbon (PFC) emulsions and acellular hemoglobin-based oxygen carriers (HBOCs). We also highlight novel oxygen-containing microparticles, nanoparticles, and stem cell-derived RBC products, with emphasis on improvements in biocompatibility and oxygen delivery. In addition, we envision future developments for the rational design of advanced blood substitutes that aim to address unmet clinical needs.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Tao Z,Ghoroghchian PPdoi
10.1016/j.tibtech.2014.05.001subject
Has Abstractpub_date
2014-09-01 00:00:00pages
466-73issue
9eissn
0167-7799issn
1879-3096pii
S0167-7799(14)00088-2journal_volume
32pub_type
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