Bioelectrochemical Power-to-Gas: State of the Art and Future Perspectives.

abstract：:One of the goals of synthetic biology is to build regulatory circuits that control cell behavior, for both basic research purposes and biomedical applications. The ability to build transcriptional regulatory devices depends on the availability of programmable, sequence-specific, and effective synthetic transcription f...

journal_title：Trends in biotechnology

authors： Jusiak B,Cleto S,Perez-Piñera P,Lu TK

更新日期：2016-07-01 00:00:00

abstract：:This article reports on the state-of-the-art technologies that sequence DNA using miniaturized devices. The article considers the miniaturization of existing technologies for sequencing DNA and the opportunities for cost reduction that 'on-chip' devices can deliver. The ability to construct nano-scale structures and p...

journal_title：Trends in biotechnology

authors： Ryan D,Rahimi M,Lund J,Mehta R,Parviz BA

更新日期：2007-09-01 00:00:00

abstract：:Lyases catalyse the cleavage of C-C, C-N, C-O and other bonds by elimination to produce double bonds or, conversely, catalyse the addition of groups to double bonds. These enzymes do not require cofactor recycling, show an absolute stereospecificity and can give a theoretical yield of 100%, compared with only 50% for ...

journal_title：Trends in biotechnology

authors： van der Werf MJ,van den Tweel WJ,Kamphuis J,Hartmans S,de Bont JA

更新日期：1994-03-01 00:00:00

abstract：:The analysis of biomolecules using microarrays and other biosensors has a significant role in molecular biotechnology, and will become even more important in the future as a versatile tool for research and diagnostics. For many applications, the synthetic DNA mimic peptide nucleic acid (PNA) could be advantageous as a...

journal_title：Trends in biotechnology

authors： Brandt O,Hoheisel JD

更新日期：2004-12-01 00:00:00

abstract：:Phytoremediation holds promise for in situ treatment of heavy metal contaminated soils. Recently, the benefits of combining siderophore-producing bacteria (SPB) with plants for metal removal from contaminated soils have been demonstrated. Metal-resistant SPB play an important role in the successful survival and growth...

journal_title：Trends in biotechnology

authors： Rajkumar M,Ae N,Prasad MN,Freitas H

更新日期：2010-03-01 00:00:00

abstract：:The well-studied antigen-combining sites of antibody molecules hold considerable promise as a model system for the design of bioactive peptides. These small, immunoglobulin-derived peptides can be used in the development of alternative treatments for disease and in diagnostic strategies. The general principles derived...

journal_title：Trends in biotechnology

authors： Dougall WC,Peterson NC,Greene MI

更新日期：1994-09-01 00:00:00

abstract：:Attempts through somatic cell nuclear transfer to expand wild populations that have shrunk to critical numbers is a logical extension of the successful cloning of mammals. However, although the first mammal was cloned 10 years ago, nuclear reprogramming remains phenomenological, with abnormal gene expression and epige...

journal_title：Trends in biotechnology

authors： Loi P,Galli C,Ptak G

更新日期：2007-05-01 00:00:00

abstract：:Small molecules are defined as low molecular weight organic compounds (typically <1000 Da), which could be either natural or artificial. Because established imaging methods are not able to selectively detect the positions, concentrations and structures of small molecules in biological samples, new methods have been de...

journal_title：Trends in biotechnology

authors： Svatos A

更新日期：2010-08-01 00:00:00

abstract：:The global movement of people and goods has increased the risk of biosecurity threats and their potential to incur large economic, social, and environmental costs. Conventional manual biosecurity surveillance methods are limited by their scalability in space and time. This article focuses on autonomous surveillance sy...

journal_title：Trends in biotechnology

authors： Jurdak R,Elfes A,Kusy B,Tews A,Hu W,Hernandez E,Kottege N,Sikka P

更新日期：2015-04-01 00:00:00

abstract：:It is possible to improve the sensitivity of immunoassays by several orders of magnitude by exploiting nanoenvironmental effects. This approach can detect trace amounts of compounds and will better illuminate the presence of signal substances in biological systems. Here we describe a method for ultrasensitive immunoas...

journal_title：Trends in biotechnology

authors： Mattiasson B,Teeparuksapun K,Lebogang L,Hedström M

更新日期：2017-11-01 00:00:00

abstract：:Starting with the Protein Data Bank (PDB) as a common ancestor, the evolution of structural databases has been driven by the rapprochement of the structural world and the practical applications. The result is an impressive number of secondary structural databases that is welcomed by structural biologists and bioinform...

journal_title：Trends in biotechnology

authors： Carugo O,Pongor S

更新日期：2002-12-01 00:00:00

abstract：:Research infrastructures are essential for top-level academic and industrial research activities. Throughout the successive framework programmes (FPs) of the EU, actions have been gradually developed to support researchers in accessing top-level European research infrastructures located outside their own country and a...

journal_title：Trends in biotechnology

authors： Péro H,Faure JE

更新日期：2007-05-01 00:00:00

abstract：:Along with the development of metabolic engineering and synthetic biology tools, various microbes are being used to produce aromatic chemicals. In microbes, aromatics are mainly produced via a common important precursor, chorismate, in the shikimate pathway. Natural or non-natural aromatics have been produced by engin...

journal_title：Trends in biotechnology

authors： Noda S,Kondo A

更新日期：2017-08-01 00:00:00

abstract：:Current biopharmaceutical manufacturing strongly relies on using purification platform processes, offering harmonization of practices and speed-to-market. However, the ability of such processes to respond quickly to anticipated higher quality and capacity demands is under question. Here, we describe novel approaches f...

journal_title：Trends in biotechnology

authors： Nfor BK,Verhaert PD,van der Wielen LA,Hubbuch J,Ottens M

更新日期：2009-12-01 00:00:00

abstract：:In recent years, entrapment of cells within spheres of Ca2+ alginate has become the most widely used technique for immobilizing living cells. This versatile method includes applications ranging from immobilization of living or dead cells in bioreactors, immobilization of plant protoplasts for micropropagation and immo...

journal_title：Trends in biotechnology

authors： Smidsrød O,Skjåk-Braek G

更新日期：1990-03-01 00:00:00

abstract：:Are current docking methods capable of building complexes from putative component protein structures? Results of recent computational studies, including those of the CAPRI (Critical Assessment of Protein Interactions) competition, were used to determine the key properties for successful docking and introduce a classif...

journal_title：Trends in biotechnology

authors： Vajda S,Camacho CJ

更新日期：2004-03-01 00:00:00

abstract：:The mapping of the human genome was completed earlier this year and efforts are underway to understand the role of gene products (i.e. proteins) in biological pathways and human disease and to exploit their functional roles to derive protein therapeutics and protein-based drugs. A key component to the next revolution ...

journal_title：Trends in biotechnology

authors： Maggio ET,Ramnarayan K

更新日期：2001-07-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease resulting from the destruction of pancreatic insulin-producing beta cells that most frequently occurs in genetically predisposed children. Recent observations illustrating the regenerative capability of the endocrine pancreas in addition to advances in stem cell and gene ...

journal_title：Trends in biotechnology

authors： Pasquali L,Fan Y,Trucco M,Ringquist S

更新日期：2006-11-01 00:00:00

abstract：:The use of antibodies or antibody fragments for targeting tumors (either for tumor imaging or as carriers for drugs or toxins), has encountered problems of clearance, and non-specific or inefficient binding in clinical trials. A novel approach, linking two antibody variable fragments (Fvs), with a short peptide to gen...

journal_title：Trends in biotechnology

authors： Bird RE,Walker BW

更新日期：1991-04-01 00:00:00

abstract：:Bacterial genomics has provided a plethora of potential targets for antibacterial drug discovery, however, success in the hunt for new antibiotics will hinge on selecting targets with the highest potential. A recent paper by Liu and coworkers describes a new approach to target selection that uncovers strategies used b...

journal_title：Trends in biotechnology

authors： Brown ED

更新日期：2004-09-01 00:00:00

abstract：:Adsorption in stable expanded beds enables proteins to be recovered directly from particulate-containing feedstocks, such as fermentation broths and preparations of disrupted cells, without the need for prior removal of the suspended solids, which would normally result in the blockage of packed beds. The adoption of t...

journal_title：Trends in biotechnology

authors： Chase HA

更新日期：1994-08-01 00:00:00

abstract：:The process of studying dynamic three-dimensional samples has a long history in biological research. Recent advances in hardware and software have made it easier to visualise and record interior detail from multiple focal planes of three-dimensional samples as they change over time (four-dimensional imaging). Once cap...

journal_title：Trends in biotechnology

authors： Thomas CF,White JG

更新日期：1998-04-01 00:00:00

abstract：:Engineered tissues need a vascular network to supply cells with nutrients and oxygen after implantation. A network that can connect to the vasculature of the patient after implantation can be included during in vitro culture. For optimal integration, this network needs to be highly organized, including venules, capill...

journal_title：Trends in biotechnology

authors： Rouwkema J,Khademhosseini A

更新日期：2016-09-01 00:00:00

abstract：:Animals exploit soft structures to move effectively in complex natural environments. These capabilities have inspired robotic engineers to incorporate soft technologies into their designs. The goal is to endow robots with new, bioinspired capabilities that permit adaptive, flexible interactions with unpredictable envi...

journal_title：Trends in biotechnology

authors： Kim S,Laschi C,Trimmer B

更新日期：2013-05-01 00:00:00

abstract：:Allergenicity prediction is one of the most challenging aspects in the safety assessment of foods derived from either biotechnology or novel food proteins. Here we present a bottom-up strategy that defines a priori the specific risk assessment (RA) needs based on a database appropriately built for such purposes. ...

journal_title：Trends in biotechnology

authors： Fernandez A,Mills ENC,Koning F,Moreno FJ

更新日期：2021-01-01 00:00:00

abstract：:The existence of a medicinal 'biotech revolution' has been widely accepted and promoted by academics, consultants, industry and government. This has generated expectations about significant improvements in the drug discovery process, healthcare and economic development that influence a considerable amount of policy-ma...

journal_title：Trends in biotechnology

authors： Nightingale P,Martin P

更新日期：2004-11-01 00:00:00

abstract：:In 2006, the group of Dr C.M. Lieber pioneered the field of nanowire sensors by fabricating devices for the ultra-sensitive label-free detection of biological macromolecules. Since then, nanowire sensors have demonstrated their ability to detect cancer-associated analytes in peripheral blood, tumor tissue, and the exh...

journal_title：Trends in biotechnology

authors： Doucey MA,Carrara S

更新日期：2019-01-01 00:00:00

abstract：:Neurodegenerative diseases are of major socioeconomic importance and represent an enormous challenge for the scientific and medical communities. Advances in molecular genetics during the past decade have begun to provide approaches for the establishment of animal models for these disorders using transgenic technology....

journal_title：Trends in biotechnology

authors： Theuring F,Thunecke M,Kosciessa U,Turner JD

更新日期：1997-08-01 00:00:00

abstract：:The drive for industrial sustainability has pushed biosurfactants to the top of the agenda of many companies. Biosurfactants offer the possibility of replacing chemical surfactants, produced from nonrenewable resources, with alternatives produced from cheap renewable feedstocks. Biosurfactants are also attractive beca...

journal_title：Trends in biotechnology

authors： Marchant R,Banat IM

更新日期：2012-11-01 00:00:00

abstract：:Hydrogels are 3D hydrophilic polymer networks that absorb and hold huge amounts of water. Although hydrogels have traditionally been synthesized using chemical and physical methods, rapid developments in enzyme technology that, like chemical-based methods, enable the formation of stable covalent bonds are fast emergin...

journal_title：Trends in biotechnology

authors： Guebitz GM,Nyanhongo GS

更新日期：2018-10-01 00:00:00