Abstract:
:Benzylisoquinoline alkaloids (BIAs) are a family of ∼2500 alkaloids with both potential and realized pharmaceutical value, including most notably the opiates such as codeine and morphine. Only a few BIAs accumulate readily in plants, which limits the pharmaceutical potential of the family. Shifting BIA production to microbial sources could provide a scalable and flexible source of these compounds in the future. This review details the current status of microbial BIA synthesis and derivatization, including rapid developments in the past 6 months culminating in the synthesis of opioids from glucose in a microbial host.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Narcross L,Fossati E,Bourgeois L,Dueber JE,Martin VJJdoi
10.1016/j.tibtech.2015.12.005subject
Has Abstractpub_date
2016-03-01 00:00:00pages
228-241issue
3eissn
0167-7799issn
1879-3096pii
S0167-7799(15)00262-0journal_volume
34pub_type
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