Two-phase partitioning bioreactors: a new technology platform for destroying xenobiotics.

abstract：:The best long-term prospects for the reduction in the number of deaths due to cancer lie with screening and prevention rather than with therapy of the advanced disease. Screening efficiency will be improved by the identification of individuals at inherited high risk of cancer. Understanding the mechanism of predisposi...

journal_title：Trends in biotechnology

authors： Ponder BA

更新日期：1990-04-01 00:00:00

abstract：:The free-radical gas nitric oxide (NO) plays an important role in a wide and diverse range of physiological processes. As progress is made in understanding the biological function of NO, there is growing interest in the possibility that inhibitors of NO synthase (NOS) may be of clinical use in the therapy of certain d...

journal_title：Trends in biotechnology

authors： Ogden JE,Moore PK

更新日期：1995-02-01 00:00:00

abstract：:Proteins found in nature have traditionally been the most frequently used biocatalysts to produce numerous natural products ranging from commodity chemicals to pharmaceuticals. Protein engineering has emerged as a powerful biotechnological toolbox in the development of metabolic engineering, particularly for the biosy...

journal_title：Trends in biotechnology

authors： Li C,Zhang R,Wang J,Wilson LM,Yan Y

更新日期：2020-07-01 00:00:00

abstract：:A key aspect of the genomics revolution is the transformation of large amounts of biological information into an electronic format, leading to an information-based approach to biomedical problems. Large-scale RNA assays and gene-expression-microarray studies, in particular, represent the second wave of the genomics re...

journal_title：Trends in biotechnology

authors： Zweiger G

更新日期：1999-11-01 00:00:00

abstract：:In situ 3D printing is an emerging technique designed for patient-specific needs and performed directly in the patient's tissues in the operating room. While this technology has progressed rapidly, several improvements are needed to push it forward for widespread utility, including ink formulations and optimization fo...

journal_title：Trends in biotechnology

authors： Agostinacchio F,Mu X,Dirè S,Motta A,Kaplan DL

更新日期：2020-12-02 00:00:00

abstract：:Tremendous advances in our understanding of the human immunodeficiency viruses (HIVs) have been made through the use of animal models. However, there are limitations inherent in many of the current models that use either nonhuman primates, or viruses other than HIV-1. Researchers continue to search for improved models...

journal_title：Trends in biotechnology

authors： Lewis AD,Johnson PR

更新日期：1995-04-01 00:00:00

abstract：:Graphene is the basic building block of 0D fullerene, 1D carbon nanotubes, and 3D graphite. Graphene has a unique planar structure, as well as novel electronic properties, which have attracted great interests from scientists. This review selectively analyzes current advances in the field of graphene bioapplications. I...

journal_title：Trends in biotechnology

authors： Wang Y,Li Z,Wang J,Li J,Lin Y

更新日期：2011-05-01 00:00:00

abstract：:Rice is the staple diet of more than three billion people. Yields must double over the next 40 years if we are to sustain the nutritional needs of the ever-expanding global population. Between 10% and 30% of the annual rice harvest is lost due to infection by the rice blast fungus Magnaporthe oryzae. Evaluation of gen...

journal_title：Trends in biotechnology

authors： Skamnioti P,Gurr SJ

更新日期：2009-03-01 00:00:00

abstract：:Soft biofunctional and biocompatible interfaces on solids designed by the deposition of ultrathin soft polymer films or supported membranes have numerous scientific and practical applications. These include the immobilization of glycolipids, membrane receptors and proteins to generate models of cell and tissue surface...

journal_title：Trends in biotechnology

authors： Sackmann E,Tanaka M

更新日期：2000-02-01 00:00:00

abstract：:Antimicrobial resistance (AMR) has developed into a huge threat to global health, and reducing it is an urgent priority for public health authorities. The importance of a healthy and balanced gut microbiome has been identified as a key protective factor against AMR development, but this can be significantly affected b...

journal_title：Trends in biotechnology

authors： Kelly SA,Rodgers AM,O'Brien SC,Donnelly RF,Gilmore BF

更新日期：2020-04-01 00:00:00

abstract：:Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues. Many synthetic or natural biomaterials have been developed for this purpose and are used to deliver wound therapeutics in a controlled manner that prevents unwan...

journal_title：Trends in biotechnology

authors： Andreadis ST,Geer DJ

更新日期：2006-07-01 00:00:00

abstract：:Benzylisoquinoline alkaloids (BIAs) are a family of ∼2500 alkaloids with both potential and realized pharmaceutical value, including most notably the opiates such as codeine and morphine. Only a few BIAs accumulate readily in plants, which limits the pharmaceutical potential of the family. Shifting BIA production to m...

journal_title：Trends in biotechnology

authors： Narcross L,Fossati E,Bourgeois L,Dueber JE,Martin VJJ

更新日期：2016-03-01 00:00:00

abstract：:Plant-based environmental remediation, or phytoremediation, has been widely pursued in recent years as a favorable clean-up technology and is an area of intensive scientific investigation. For the vast majority of field applications, vegetative 'phyto-crops' are selected specifically for their capacity for site decont...

journal_title：Trends in biotechnology

authors： Rugh CL

更新日期：2004-10-01 00:00:00

abstract：:Reconstituted viral envelopes (RVEs) are formed by solubilizing intact virus in detergent and reassembling the envelope on removal of detergent. RVEs can be formed in the presence of agents that become encapsulated and can then be utilized in vitro and in vivo for drug delivery, cell destruction, transfer of membrane ...

journal_title：Trends in biotechnology

authors： Blumenthal R,Loyter A

更新日期：1991-02-01 00:00:00

abstract：:Pressure is a thermodynamic parameter whose unique effects on biological systems are increasingly being studied in a growing number of scientific fields. As such, the effects of high pressure are currently being investigated at different levels, ranging from proteins, enzymes and viruses to microorganisms, mammalian c...

journal_title：Trends in biotechnology

authors： Aertsen A,Meersman F,Hendrickx ME,Vogel RF,Michiels CW

更新日期：2009-07-01 00:00:00

abstract：:Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms...

journal_title：Trends in biotechnology

authors： Cardenas ME,Sanfridson A,Cutler NS,Heitman J

更新日期：1998-10-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease resulting from the destruction of pancreatic insulin-producing beta cells that most frequently occurs in genetically predisposed children. Recent observations illustrating the regenerative capability of the endocrine pancreas in addition to advances in stem cell and gene ...

journal_title：Trends in biotechnology

authors： Pasquali L,Fan Y,Trucco M,Ringquist S

更新日期：2006-11-01 00:00:00

abstract：:Recent innovations in the materials used for bioprinting have enabled transformative gains in the resolution and architecture of 3D-printed engineered tissues. We focus here on one of these innovations, reported by Lee et al., which lowers the resolution limit for printing soft biomaterials. ...

journal_title：Trends in biotechnology

authors： Corbett DC,Olszewski E,Stevens K

更新日期：2019-11-01 00:00:00

abstract：:Marine natural products (NP) are unanimously acknowledged as the 'blue gold' in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolit...

journal_title：Trends in biotechnology

authors： Leal MC,Calado R,Sheridan C,Alimonti A,Osinga R

更新日期：2013-10-01 00:00:00

abstract：:Cyanobacteria promise to be an important industrial platform for the production of a variety of biobased products such as fuels, plastics, and isoprenoids. Recent advances in synthetic biology have resulted in various cyanobacterial strain improvements. Nevertheless, these new strains are still hampered by product inh...

journal_title：Trends in biotechnology

authors： van den Berg C,Eppink MHM,Wijffels RH

更新日期：2019-05-01 00:00:00

abstract：:Vascularisation is key to developing large transplantable tissue constructs capable of providing therapeutic benefits. The vascularised tissue engineering chamber originates from surgical concepts in tissue prefabrication and microsurgery. It serves as an in vivo bioreactor in the form of a closed, protected space sur...

journal_title：Trends in biotechnology

authors： Yap KK,Yeoh GC,Morrison WA,Mitchell GM

更新日期：2018-10-01 00:00:00

abstract：:Photodynamic therapy (PDT) involves the use of a class of molecules that are activated by light, and which accumulate in, and are retained by, certain abnormal tissues. When these molecules (known as photosensitizers) are activated by light, they cause the formation of active forms of oxygen, which result in the killi...

journal_title：Trends in biotechnology

authors： Levy JG

更新日期：1995-01-01 00:00:00

abstract：:Along with the great strides that have been made towards understanding cancer, has come a realization of the complexity of molecular events that lead to malignancy. Proteomics-based approaches, which enable the quantitative investigation of both cellular protein expression levels and protein-protein interactions invol...

journal_title：Trends in biotechnology

authors： Simpson RJ,Dorow DS

更新日期：2001-10-01 00:00:00

abstract：:Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which relies on the use of nanotechnologies to fight disease, was envisaged to fulfill this coveted goal. Despite substantial progress, the struc...

journal_title：Trends in biotechnology

authors： Lussier F,Staufer O,Platzman I,Spatz JP

更新日期：2020-09-07 00:00:00

abstract：:Europe has led many aspects of gene research and yet it has been unable to translate these discoveries into a globally dominant industrial sector. There are valid societal, political and financial reasons for its reluctance to deploy agricultural biotechnology but this reluctance might have unintended consequences. It...

journal_title：Trends in biotechnology

authors： Enriquez J

更新日期：2001-04-01 00:00:00

abstract：:Dual-use research, which results in knowledge that can be used for both good and ill, has become increasingly accessible in the internet age to both scientists and the general public. Here, we outline some major milestones for dual-use policy and present three vignettes that highlight contemporary dual-use issues in b...

journal_title：Trends in biotechnology

authors： Getz LJ,Dellaire G

更新日期：2018-12-01 00:00:00

abstract：:The hand-held gene gun provides a rapid and efficient method of incorporating fluorescent dyes into cells, a technique that is becoming known as diolistics. Transporting fluorescent dyes into cells has, in the past, used predominantly injection or chemical methods. The use of the gene gun, combined with the new genera...

journal_title：Trends in biotechnology

authors： O'Brien JA,Lummis SC

更新日期：2007-11-01 00:00:00

abstract：:Cyclodextrins, macrocyclic carbohydrates with apolar internal cavities, can form complexes with, and solubilize many normally water-insoluble compounds. Ferrocene and its derivatives, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with ...

journal_title：Trends in biotechnology

authors： Luong JH,Brown RS,Male KB,Cattaneo MV,Zhao S

更新日期：1995-11-01 00:00:00

abstract：:Challenges in demonstrating interchangeability and safety, as well as the ongoing evolution of regulations governing biosimilars, have meant that the development of the biosimilars industry has not been, and will not be, a carbon copy of the generics industry. Complexity in the development process reduces the cost adv...

journal_title：Trends in biotechnology

authors： Konara CS,Barnard RT,Hine D,Siegel E,Ferro V

更新日期：2016-01-01 00:00:00

abstract：:The spatial distribution of molecules and cells is fundamental to understanding biological systems. Traditionally, microscopies based on electromagnetic waves such as visible light have been used to localize cellular components by direct visualization. However, these techniques suffer from limitations of transmissibil...

journal_title：Trends in biotechnology

authors： Boulgakov AA,Ellington AD,Marcotte EM

更新日期：2020-02-01 00:00:00