Abstract：
:Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) components in an important interface whose correct functioning is critical to maintain brain health. Tissue engineering is now offering new tools and insights to advance our understanding of NVU function. Here, we review how the use of novel biomaterials to mimic the mechanical and functional cues of the ECM, coupled with precisely layered deposition of the different cells of the NVU through 3D bioprinting, is revolutionising the study of neurovascular function and dysfunction.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Potjewyd G,Moxon S,Wang T,Domingos M,Hooper NMdoi
10.1016/j.tibtech.2018.01.003subject
Has Abstractpub_date
2018-04-01 00:00:00pages
457-472issue
4eissn
0167-7799issn
1879-3096pii
S0167-7799(18)30024-6journal_volume
36pub_type
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