Advances in the manufacture of MIP nanoparticles.

abstract：:Toxic organic compounds (xenobiotics) pose serious environmental and health risks worldwide. Biological treatment of these materials is severely constrained by their toxic and inhibitory nature and great care is required with respect to the rate at which they are provided to cells. The use of a second, distinct, organ...

journal_title：Trends in biotechnology

authors： Daugulis AJ

更新日期：2001-11-01 00:00:00

abstract：:This review summarizes synthetic chromosome construction in plants and speculates on how they might be applied to various uses in the future, as well as the possible impact for synthetic biology. The procedures to construct foundational platforms for synthetic chromosomes in plants are described, together with some ch...

journal_title：Trends in biotechnology

authors： Birchler JA

更新日期：2015-03-01 00:00:00

abstract：:Stem cell differentiation is regulated by the complex interplay of multiple parameters, including adhesive intercellular interactions, cytoskeletal and extracellular matrix remodeling, and gradients of agonists and antagonists that individually and collectively vary as a function of spatial locale and temporal stages ...

journal_title：Trends in biotechnology

authors： Kinney MA,McDevitt TC

更新日期：2013-02-01 00:00:00

abstract：:The expression 'crystal clear' stems from the science of crystallography, which determines the detailed atomic structures of materials by exposing crystals to X-rays. Protein structures are pivotal to the success of rational drug design and other biotechnology applications; however, obtaining high quality crystals pos...

journal_title：Trends in biotechnology

authors： Saridakis E,Chayen NE

更新日期：2009-02-01 00:00:00

abstract：:The existence of a medicinal 'biotech revolution' has been widely accepted and promoted by academics, consultants, industry and government. This has generated expectations about significant improvements in the drug discovery process, healthcare and economic development that influence a considerable amount of policy-ma...

journal_title：Trends in biotechnology

authors： Nightingale P,Martin P

更新日期：2004-11-01 00:00:00

abstract：:Vascularisation is key to developing large transplantable tissue constructs capable of providing therapeutic benefits. The vascularised tissue engineering chamber originates from surgical concepts in tissue prefabrication and microsurgery. It serves as an in vivo bioreactor in the form of a closed, protected space sur...

journal_title：Trends in biotechnology

authors： Yap KK,Yeoh GC,Morrison WA,Mitchell GM

更新日期：2018-10-01 00:00:00

abstract：:Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues. Many synthetic or natural biomaterials have been developed for this purpose and are used to deliver wound therapeutics in a controlled manner that prevents unwan...

journal_title：Trends in biotechnology

authors： Andreadis ST,Geer DJ

更新日期：2006-07-01 00:00:00

abstract：:Along with the great strides that have been made towards understanding cancer, has come a realization of the complexity of molecular events that lead to malignancy. Proteomics-based approaches, which enable the quantitative investigation of both cellular protein expression levels and protein-protein interactions invol...

journal_title：Trends in biotechnology

authors： Simpson RJ,Dorow DS

更新日期：2001-10-01 00:00:00

abstract：:Building robust manufacturing processes from biological components is a task that is highly complex and requires sophisticated tools to describe processes, inputs, and measurements and administrate management of knowledge, data, and materials. We argue that for bioengineering to fully access biological potential, it w...

journal_title：Trends in biotechnology

authors： Sadowski MI,Grant C,Fell TS

更新日期：2016-03-01 00:00:00

abstract：:The generation of genetically engineered (GE) foods has been raising several concerns and controversies that divide not only the general public but also the scientific community. The fear and importance of the new technology, as well as commercial interests, have supported many of the ongoing discussions. The recent i...

journal_title：Trends in biotechnology

authors： Batista R,Oliveira MM

更新日期：2009-05-01 00:00:00

abstract：:The genetic code is the manual that cells use to incorporate amino acids into proteins. It is possible to artificially expand this manual through cellular, molecular, and chemical manipulations to improve protein functionality. Strategies for in vivo genetic code expansion are under the same functional constraints as ...

journal_title：Trends in biotechnology

authors： Ros E,Torres AG,Ribas de Pouplana L

更新日期：2020-09-04 00:00:00

abstract：:The diffusion of genetically modified (GM) animals has generated a demand for accurate and unique identification to assure compliance with relevant national and international legislation. Individual identification of GM animals is essential to improve safety and traceability, as well as to fulfill the present and futu...

journal_title：Trends in biotechnology

authors： Forabosco F,Sundström FL,Rydhmer L

更新日期：2013-05-01 00:00:00

abstract：:Rising global demand for meat will result in increased environmental pollution, energy consumption, and animal suffering. Cultured meat, produced in an animal-cell cultivation process, is a technically feasible alternative lacking these disadvantages, provided that an animal-component-free growth medium can be develop...

journal_title：Trends in biotechnology

authors： van der Weele C,Tramper J

更新日期：2014-06-01 00:00:00

abstract：:Patterned regular sieves and filters with comparable molecular dimensions hold great promise as an alternative to conventional polymeric gels and fibrous membranes to improve biomolecule separation. Recent developments of microfabricated nanofluidic sieves and filters have demonstrated superior performance for both an...

journal_title：Trends in biotechnology

authors： Fu J,Mao P,Han J

更新日期：2008-06-01 00:00:00

abstract：:The extensive use of chemical insecticides for insect pest management has resulted in insecticide resistance now being recorded in >500 species of insects and mites. Although gut-active toxins such as those derived from Bacillus thuringiensis (Bt) have been successfully used for insect pest management, a diverse range...

journal_title：Trends in biotechnology

authors： Bonning BC,Chougule NP

更新日期：2014-02-01 00:00:00

abstract：:The best long-term prospects for the reduction in the number of deaths due to cancer lie with screening and prevention rather than with therapy of the advanced disease. Screening efficiency will be improved by the identification of individuals at inherited high risk of cancer. Understanding the mechanism of predisposi...

journal_title：Trends in biotechnology

authors： Ponder BA

更新日期：1990-04-01 00:00:00

abstract：:Luminescence has assumed an important role in analytical biochemistry and molecular biology as an extremely sensitive method for determining the concentration of specific ions and molecules. The luminescent system of the jellyfish Aequorea victoria consists of the photoprotein aequorin, which contains the molecule coe...

journal_title：Trends in biotechnology

authors： Jones K,Hibbert F,Keenan M

更新日期：1999-12-01 00:00:00

abstract：:N-linked glycoproteins include such biologically important molecules as cell-surface receptors, cell-adhesion molecules, immunoglobulins and other serum proteins, and tumor antigens. Investigating the role of carbohydrate in glycoprotein function has included the use of glycosylation inhibitors or site-directed mutage...

journal_title：Trends in biotechnology

authors： Elbein AD

更新日期：1991-10-01 00:00:00

abstract：:Unbalanced production of atmospheric CO(2) constitutes a major challenge to global sustainability. Technologies have thus been developed for enhanced biological carbon fixation (also referred to as CO(2) mitigation), and one of the most promising capitalizes on microalgae. However, the "best bioreactor", which would b...

journal_title：Trends in biotechnology

authors： Kumar A,Ergas S,Yuan X,Sahu A,Zhang Q,Dewulf J,Malcata FX,van Langenhove H

更新日期：2010-07-01 00:00:00

abstract：:Short, self-assembling peptides form a variety of stable nanostructures used for the rational design of functional devices. Peptides serve as organic templates for conjugating biorecognition elements, and assembling ordered nanoparticle arrays and hybrid supramolecular structures. We are witnessing the emergence of a ...

journal_title：Trends in biotechnology

authors： Lakshmanan A,Zhang S,Hauser CA

更新日期：2012-03-01 00:00:00

abstract：:Microbial consortia have been used in biotechnology processes, including fermentation, waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly engineering microbial consortia for diverse applications, including the bioproduction of medicines, biofuels, and biomaterials from inexpe...

journal_title：Trends in biotechnology

authors： McCarty NS,Ledesma-Amaro R

更新日期：2019-02-01 00:00:00

abstract：:Most infections are caused by bacteria, many of which are ever-evolving and resistant to nearly all available antibiotics. β-Lactams and glycopeptides are used to combat these infections by inhibiting bacterial cell-wall synthesis. This mechanism remains an interesting target in the search for new antibiotics in light...

journal_title：Trends in biotechnology

authors： Jovetic S,Zhu Y,Marcone GL,Marinelli F,Tramper J

更新日期：2010-12-01 00:00:00

abstract：:Predicting the future use of biocatalysts for the transformation of organic compounds--both natural substrates and other compounds--needs to take many factors into account. To date, relatively few biotransformations have been developed to the industrial scale, primarily because there has been little economic incentive...

journal_title：Trends in biotechnology

authors： Faber K,Franssen MC

更新日期：1993-11-01 00:00:00

abstract：:Challenges in demonstrating interchangeability and safety, as well as the ongoing evolution of regulations governing biosimilars, have meant that the development of the biosimilars industry has not been, and will not be, a carbon copy of the generics industry. Complexity in the development process reduces the cost adv...

journal_title：Trends in biotechnology

authors： Konara CS,Barnard RT,Hine D,Siegel E,Ferro V

更新日期：2016-01-01 00:00:00

abstract：:A major goal of material science is to produce hierarchical materials that are ordered on all length scales, from the molecular (1-100 A) via the nano (10-100 nm) to the meso (1-100 microm). In these materials, the larger-scale properties can be controlled by choosing molecular characteristics. Methods developed to pr...

journal_title：Trends in biotechnology

authors： Dan N

更新日期：2000-09-01 00:00:00

abstract：:The effective management of emerging insect-borne disease is dependent on the use of safe and efficacious chemical insecticides. Given the inherent ability of insects to develop resistance, it is essential to propose innovative strategies because insecticides remain the most important element of integrated approaches ...

journal_title：Trends in biotechnology

authors： Lapied B,Pennetier C,Apaire-Marchais V,Licznar P,Corbel V

更新日期：2009-04-01 00:00:00

abstract：:Although many microorganisms have been used for the bioindustrial generation of valuable metabolites, the productive potential of cyanobacterial species has remained largely unexplored. Cyanobacteria possess several advantages as organisms for bioindustrial processes, including simple input requirements, tolerance of ...

journal_title：Trends in biotechnology

authors： Ducat DC,Way JC,Silver PA

更新日期：2011-02-01 00:00:00

abstract：:Opinions on what synthetic biology actually is range from a natural extension of genetic engineering to a new manufacturing paradigm. It offers, for the first time in the life sciences, rational design and engineering standardisation. It could address problems across a broad spectrum of human concerns, including energ...

journal_title：Trends in biotechnology

authors： Philp JC,Ritchie RJ,Allan JE

更新日期：2013-05-01 00:00:00

abstract：:Vibrational spectroscopy using both infrared and Raman spectroscopies has been used in recent years with the aim to aid clinicians in disease diagnosis. More recently, these techniques have been applied to study stem cell differentiation and to determine stem cell presence in tissues. These studies have demonstrated t...

journal_title：Trends in biotechnology

authors： Sulé-Suso J,Forsyth NR,Untereiner V,Sockalingum GD

更新日期：2014-05-01 00:00:00

abstract：:Despite the recognized potential of viral vectors for gene therapy, growing biological concerns are prompting the exploration of safer, non-viral vectors to deliver therapeutic nucleic acids. In this context, recombinant proteins can be bioproduced on a large scale, without the need for further in vitro modifications,...

journal_title：Trends in biotechnology

authors： Arís A,Villaverde A

更新日期：2004-07-01 00:00:00