Abstract:
:There are many aims associated with the optimization of fermentation processes. Optimization is expected to increase the yield of the final product but the process must be compliant with good manufacturing practices, the available equipment and the expected final scale of operation. Dealing with genetically modified microorganisms that overproduce recombinant protein has the advantage that the vast majority of the processes use only three different species, namely Escherichia coli, Saccharomyces cerevisiae and Pichia pastoris. Standard processes for each organism are described in textbooks and serve as a basis for the development of a tailored process. This article outlines the general philosophy that we have devised to ensure an efficient approach of scaling up fermentation processes for biopharmaceutical purposes, in a multidisciplinary environment.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Thiry M,Cingolani Ddoi
10.1016/s0167-7799(02)01913-3subject
Has Abstractpub_date
2002-03-01 00:00:00pages
103-5issue
3eissn
0167-7799issn
1879-3096pii
S0167-7799(02)01913-3journal_volume
20pub_type
杂志文章abstract::Targeting apoptotic cell death pathways provides wide-ranging opportunities for the discovery and development of novel drugs. Some targeted therapies that selectively induce apoptosis in cancer cells are already marketed, and numerous pro-apoptotic drugs for treating cancer are currently being developed. The anti-apop...
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journal_title:Trends in biotechnology
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pub_type: 杂志文章,评审
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