Drugs against superbugs: private lessons from bacteriophages.

abstract：:Stem cell differentiation is regulated by the complex interplay of multiple parameters, including adhesive intercellular interactions, cytoskeletal and extracellular matrix remodeling, and gradients of agonists and antagonists that individually and collectively vary as a function of spatial locale and temporal stages ...

journal_title：Trends in biotechnology

authors： Kinney MA,McDevitt TC

更新日期：2013-02-01 00:00:00

abstract：:The general acceptance of bioremediation technology as an environmentally sound and economic treatment for hazardous waste requires the demonstration of its efficacy, reliability and predictability, as well as its advantages over conventional treatments. An effective monitoring design includes protocols for treatment-...

journal_title：Trends in biotechnology

authors： Heitzer A,Sayler GS

更新日期：1993-08-01 00:00:00

abstract：:Carotenoids are micronutrients important for human health. The continuous improvements in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome-editing techniques make rapid, DNA/transgene-free and targeted multiplex genetic modification a reality, thus promising to accelerate the breeding an...

journal_title：Trends in biotechnology

authors： Zheng X,Kuijer HNJ,Al-Babili S

更新日期：2020-12-29 00:00:00

abstract：:In recent years, entrapment of cells within spheres of Ca2+ alginate has become the most widely used technique for immobilizing living cells. This versatile method includes applications ranging from immobilization of living or dead cells in bioreactors, immobilization of plant protoplasts for micropropagation and immo...

journal_title：Trends in biotechnology

authors： Smidsrød O,Skjåk-Braek G

更新日期：1990-03-01 00:00:00

abstract：:Selective delivery of lethal levels of drugs to tumors, without concomitant damage to normal tissues, is a major challenge in cancer chemotherapy. Prodrugs used in conjunction with enzyme-monoclonal antibody conjugates that can target tumors and convert prodrugs to their active drug forms in situ, offer exceptional pr...

journal_title：Trends in biotechnology

authors： Huennekens FM

更新日期：1994-06-01 00:00:00

abstract：:Targeting apoptotic cell death pathways provides wide-ranging opportunities for the discovery and development of novel drugs. Some targeted therapies that selectively induce apoptosis in cancer cells are already marketed, and numerous pro-apoptotic drugs for treating cancer are currently being developed. The anti-apop...

journal_title：Trends in biotechnology

authors： Alam JJ

更新日期：2003-11-01 00:00:00

abstract：:Flow cytometry is a rapid method for the quantitative measurement of light scattering and fluorescent properties of cells. Although this technique has been widely applied to biomedical and environmental studies, its potential as a tool in ecotoxicological studies has not yet been fully exploited. This article describe...

journal_title：Trends in biotechnology

authors： Stauber JL,Franklin NM,Adams MS

更新日期：2002-04-01 00:00:00

abstract：:The diffusion of genetically modified (GM) animals has generated a demand for accurate and unique identification to assure compliance with relevant national and international legislation. Individual identification of GM animals is essential to improve safety and traceability, as well as to fulfill the present and futu...

journal_title：Trends in biotechnology

authors： Forabosco F,Sundström FL,Rydhmer L

更新日期：2013-05-01 00:00:00

abstract：:A switch from a petroleum-based to a biobased economy requires the capacity to produce both high-value low-volume and low-value high-volume products. Recent evidence supports the development of microalgae-based microbial cell factories with the objective of establishing environmentally sustainable manufacturing soluti...

journal_title：Trends in biotechnology

authors： Butler T,Kapoore RV,Vaidyanathan S

更新日期：2020-06-01 00:00:00

abstract：:In situ 3D printing is an emerging technique designed for patient-specific needs and performed directly in the patient's tissues in the operating room. While this technology has progressed rapidly, several improvements are needed to push it forward for widespread utility, including ink formulations and optimization fo...

journal_title：Trends in biotechnology

authors： Agostinacchio F,Mu X,Dirè S,Motta A,Kaplan DL

更新日期：2020-12-02 00:00:00

abstract：:One of the goals of synthetic biology is to build regulatory circuits that control cell behavior, for both basic research purposes and biomedical applications. The ability to build transcriptional regulatory devices depends on the availability of programmable, sequence-specific, and effective synthetic transcription f...

journal_title：Trends in biotechnology

authors： Jusiak B,Cleto S,Perez-Piñera P,Lu TK

更新日期：2016-07-01 00:00:00

abstract：:Modern biocatalysis is developing new and precise tools to improve a wide range of production processes, which reduce energy and raw material consumption and generate less waste and toxic side-products. Biocatalysis is also achieving new advances in environmental fields, from enzymatic bioremediation to the synthesis ...

journal_title：Trends in biotechnology

authors： Alcalde M,Ferrer M,Plou FJ,Ballesteros A

更新日期：2006-06-01 00:00:00

abstract：:The lantibiotics are a unique class of bacterium-derived peptide antibiotics, all of which contain the rare amino acid lanthionine, as well as a number of other nonprotein amino acids. Unlike most other peptide antibiotics, lantibiotics are produced on the ribosome as a prepeptide, and a series of post-translational m...

journal_title：Trends in biotechnology

authors： Jack RW,Sahl HG

更新日期：1995-07-01 00:00:00

abstract：:One of the central problems in bioinformatics is data retrieval and integration. The existing biological databases are geographically distributed across the Internet, complex and heterogeneous in data types and data structures, and constantly changing. With the current rapid growth of biomedical data, the challenge is...

journal_title：Trends in biotechnology

authors： Chung SY,Wong L

更新日期：1999-09-01 00:00:00

abstract：:Nitrous oxide (N(2)O), the third most abundant greenhouse gas (GHG), is highly stable and plays a significant role in stratospheric ozone destruction. The primary anthropogenic source of N(2)O stems from use of nitrogen fertilizers in soil. The bacterial enzyme nitrous oxide reductase (N(2)OR), naturally found in some...

journal_title：Trends in biotechnology

authors： Wan S,Ward TL,Altosaar I

更新日期：2012-08-01 00:00:00

abstract：:Atherosclerosis and heart disease are still the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts but the patency of such grafts is limited compared to natural materials. Tissue engineering, whereby living tissue replacements can be co...

journal_title：Trends in biotechnology

authors： Sales KM,Salacinski HJ,Alobaid N,Mikhail M,Balakrishnan V,Seifalian AM

更新日期：2005-09-01 00:00:00

abstract：:Soft biofunctional and biocompatible interfaces on solids designed by the deposition of ultrathin soft polymer films or supported membranes have numerous scientific and practical applications. These include the immobilization of glycolipids, membrane receptors and proteins to generate models of cell and tissue surface...

journal_title：Trends in biotechnology

authors： Sackmann E,Tanaka M

更新日期：2000-02-01 00:00:00

abstract：:Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They are resistant to nuclease and protease attack in serum...

journal_title：Trends in biotechnology

authors： Buchardt O,Egholm M,Berg RH,Nielsen PE

更新日期：1993-09-01 00:00:00

abstract：:The concept of ecological 'traps' is based in theory from ecology and conservation biology that has now found application to infectious diseases with a study from Paul Turner's group. This study is important because it offers a mathematical model of ecological traps, applies this model to viruses, and tests the model ...

journal_title：Trends in biotechnology

authors： Long CD,Turner-Shelef K,Relman DA

更新日期：2007-12-01 00:00:00

abstract：:Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) components in an important interface whose correct functioning is crit...

journal_title：Trends in biotechnology

authors： Potjewyd G,Moxon S,Wang T,Domingos M,Hooper NM

更新日期：2018-04-01 00:00:00

abstract：:In this article, the current status of membrane bioreactor (MBR) technology for wastewater treatment is reviewed. Fundamental facets of the MBR process and membrane and process configurations are outlined and the advantages and disadvantages over conventional suspended growth-based biotreatment are briefly identified....

journal_title：Trends in biotechnology

authors： Judd S

更新日期：2008-02-01 00:00:00

abstract：:A recent publication has reported the fabrication of a new microbial culture device containing an array of unprecedented density - a million growth chambers. This micro-Petri chip should impact on various fields, including biotechnology, ecology, food microbiology and drug development, by enabling high-throughput scre...

journal_title：Trends in biotechnology

authors： Gefen O,Balaban NQ

更新日期：2008-07-01 00:00:00

abstract：:Mutasynthesis couples the power of chemical synthesis with molecular biology to generate derivatives of medicinally valuable, natural products. Recently, this technique has been exploited by Cambridge-based biotech company Biotica Technology Ltd, and their collaborators, to generate promising new variants of the polyk...

journal_title：Trends in biotechnology

authors： Weissman KJ

更新日期：2007-04-01 00:00:00

abstract：:The baculovirus expression system has been used extensively for the expression of recombinant proteins in insect cells. Recently, recombinant baculovirus vectors engineered to contain mammalian cell-active promoter elements, have been used successfully for transient and stable gene delivery in a broad spectrum of prim...

journal_title：Trends in biotechnology

authors： Kost TA,Condreay JP

更新日期：2002-04-01 00:00:00

abstract：:Colloidal gas aphrons are microbubbles encapsulated by surfactant multilayers. They provide a large interfacial area to adsorb charged and/or hydrophobic molecules; the extent and mechanism of the adsorption depends on the surfactant multilayer. The physical properties of colloidal gas aphrons have recently been chara...

journal_title：Trends in biotechnology

authors： Jauregi P,Varley J

更新日期：1999-10-01 00:00:00

abstract：:Technology is a social practice that embodies the capacity of societies to transform themselves by creating and manipulating not only physical objects, but also symbols and cultural forms. It is an illusion that scientific and socioeconomic drivers are the sole elements determining the destiny of a technology. Althoug...

journal_title：Trends in biotechnology

authors： Mordini E

更新日期：2007-12-01 00:00:00

abstract：:Enantiomerically pure cyanohydrins are important synthetic intermediates for pharmaceuticals and agrochemicals. They are produced by enzyme-catalysed synthesis using oxynitrilases. Sufficient quantities of enzyme are available via cheap natural sources and there have been recent advances in overexpression production o...

journal_title：Trends in biotechnology

authors： Griengl H,Schwab H,Fechter M

更新日期：2000-06-01 00:00:00

abstract：:Bioremediation differs from other industrial biotechnologies in that, although bioremediation contractors must profit from the activity, the primary driver is regulatory compliance rather than manufacturing profit. It is an attractive technology in the context of a bioeconomy but currently has limitations at the field...

journal_title：Trends in biotechnology

authors： Gillespie IM,Philp JC

更新日期：2013-06-01 00:00:00

abstract：:We have isolated several microorganisms that are adapted to living in the extremes of the deep-sea environment. They include barophilic bacteria, which are able to grow at high hydrostatic pressure, but that are unable to grow at atmospheric pressure, and organic-solvent-tolerant bacteria, which are able to grow in th...

journal_title：Trends in biotechnology

authors： Kato C,Inoue A,Horikoshi K

更新日期：1996-01-01 00:00:00

abstract：:In vitro selection from molecular libraries has rapidly come of age as a protein-engineering tool. Dramatic increases in protein affinity can be engineered using phage-display libraries, and specific antibodies can be selected directly from a single 'naïve' library of their genes. Repertoires of small molecules are a ...

journal_title：Trends in biotechnology

authors： Clackson T,Wells JA

更新日期：1994-05-01 00:00:00