Engineering biofilm formation and dispersal.

Abstract:

:Anywhere water is in the liquid state, bacteria will exist as biofilms, which are complex communities of cells that are cemented together. Although frequently associated with disease and biofouling, biofilms are also important for engineering applications, such as bioremediation, biocatalysis and microbial fuel cells. Here, we review approaches to alter genetic circuits and cell signaling towards controlling biofilm formation, and emphasize utilizing these tools for engineering applications. Based on a better understanding of the genetic basis of biofilm formation, we find that biofilms might be controlled by manipulating extracellular signals, and that they might be dispersed using conserved intracellular signals and regulators. Biofilms could also be formed at specific locations where they might be engineered to make chemicals or treat human disease.

journal_name

Trends Biotechnol

journal_title

Trends in biotechnology

authors

Wood TK,Hong SH,Ma Q

doi

10.1016/j.tibtech.2010.11.001

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

87-94

issue

2

eissn

0167-7799

issn

1879-3096

pii

S0167-7799(10)00197-6

journal_volume

29

pub_type

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