Engineering biofilm formation and dispersal.


:Anywhere water is in the liquid state, bacteria will exist as biofilms, which are complex communities of cells that are cemented together. Although frequently associated with disease and biofouling, biofilms are also important for engineering applications, such as bioremediation, biocatalysis and microbial fuel cells. Here, we review approaches to alter genetic circuits and cell signaling towards controlling biofilm formation, and emphasize utilizing these tools for engineering applications. Based on a better understanding of the genetic basis of biofilm formation, we find that biofilms might be controlled by manipulating extracellular signals, and that they might be dispersed using conserved intracellular signals and regulators. Biofilms could also be formed at specific locations where they might be engineered to make chemicals or treat human disease.


Trends Biotechnol


Trends in biotechnology


Wood TK,Hong SH,Ma Q




Has Abstract


2011-02-01 00:00:00














  • From genes to protein structure and function: novel applications of computational approaches in the genomic era.

    abstract::The genome-sequencing projects are providing a detailed 'parts list' of life. A key to comprehending this list is understanding the function of each gene and each protein at various levels. Sequence-based methods for function prediction are inadequate because of the multifunctional nature of proteins. However, just kn...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Skolnick J,Fetrow JS

    更新日期:2000-01-01 00:00:00

  • Platelet-Derived Products in Veterinary Medicine: A New Trend or an Effective Therapy?

    abstract::Platelet-derived products (PDPs) have gained popularity, mainly due to their high concentrations of bioactive molecules such as growth factors and cytokines, which play important roles in tissue healing and regeneration. PDPs are obtained through minimally invasive procedures and their therapeutic effect has been wide...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Soares CS,Babo PS,Reis RL,Carvalho PP,Gomes ME

    更新日期:2020-08-28 00:00:00

  • Protein Engineering for Improving and Diversifying Natural Product Biosynthesis.

    abstract::Proteins found in nature have traditionally been the most frequently used biocatalysts to produce numerous natural products ranging from commodity chemicals to pharmaceuticals. Protein engineering has emerged as a powerful biotechnological toolbox in the development of metabolic engineering, particularly for the biosy...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Li C,Zhang R,Wang J,Wilson LM,Yan Y

    更新日期:2020-07-01 00:00:00

  • Coral aquaculture to support drug discovery.

    abstract::Marine natural products (NP) are unanimously acknowledged as the 'blue gold' in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolit...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Leal MC,Calado R,Sheridan C,Alimonti A,Osinga R

    更新日期:2013-10-01 00:00:00

  • Microbiome Tools for Forensic Science.

    abstract::Microbes are present at every crime scene and have been used as physical evidence for over a century. Advances in DNA sequencing and computational approaches have led to recent breakthroughs in the use of microbiome approaches for forensic science, particularly in the areas of estimating postmortem intervals (PMIs), l...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Metcalf JL,Xu ZZ,Bouslimani A,Dorrestein P,Carter DO,Knight R

    更新日期:2017-09-01 00:00:00

  • Unearthing Hidden Chemical Potential from Discarded Actinobacterial Libraries.

    abstract::The redundancy of natural product biosynthesis in microbes poses a practical challenge for discovering new antimicrobial compounds from bacteria. The recent application of clustered regularly interspaced short palindromic repeats (CRISPR) technology by Culp et al. to inactivate the production of abundant antibiotics g...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Timmermans ML,Ross AC

    更新日期:2020-01-01 00:00:00

  • Learning from Nature to Expand the Genetic Code.

    abstract::The genetic code is the manual that cells use to incorporate amino acids into proteins. It is possible to artificially expand this manual through cellular, molecular, and chemical manipulations to improve protein functionality. Strategies for in vivo genetic code expansion are under the same functional constraints as ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Ros E,Torres AG,Ribas de Pouplana L

    更新日期:2020-09-04 00:00:00

  • Rethinking production of Taxol® (paclitaxel) using endophyte biotechnology.

    abstract::Taxol® (generic name paclitaxel) represents one of the most clinically valuable natural products known to mankind in the recent past. More than two decades have elapsed since the notable discovery of the first Taxol®-producing endophytic fungus, which was followed by a plethora of reports on other endophytes possessin...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Kusari S,Singh S,Jayabaskaran C

    更新日期:2014-06-01 00:00:00

  • Nanoenvironmental Effects Dramatically Influence the Sensitivity of Immunoassays.

    abstract::It is possible to improve the sensitivity of immunoassays by several orders of magnitude by exploiting nanoenvironmental effects. This approach can detect trace amounts of compounds and will better illuminate the presence of signal substances in biological systems. Here we describe a method for ultrasensitive immunoas...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Mattiasson B,Teeparuksapun K,Lebogang L,Hedström M

    更新日期:2017-11-01 00:00:00

  • Decellularized Extracellular Matrix for Bioengineering Physiomimetic 3D in Vitro Tumor Models.

    abstract::Recent advances in the extraction and purification of decellularized extracellular matrix (dECM) obtained from healthy or malignant tissues open new avenues for engineering physiomimetic 3D in vitro tumor models, which closely recapitulate key biomolecular hallmarks and the dynamic cancer cell-ECM interactions in the ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Ferreira LP,Gaspar VM,Mano JF

    更新日期:2020-12-01 00:00:00

  • Toward nanoscale genome sequencing.

    abstract::This article reports on the state-of-the-art technologies that sequence DNA using miniaturized devices. The article considers the miniaturization of existing technologies for sequencing DNA and the opportunities for cost reduction that 'on-chip' devices can deliver. The ability to construct nano-scale structures and p...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Ryan D,Rahimi M,Lund J,Mehta R,Parviz BA

    更新日期:2007-09-01 00:00:00

  • Inducible systems see the light.

    abstract::Advances in our capacity to design and use novel strategies for achieving inducible gene expression will improve our ability to define gene function. An extremely efficient system designed by nature -- that of the regulatable phytochrome system in plants -- has provided the basis for developing a novel inducible gene ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Keyes WM,Mills AA

    更新日期:2003-02-01 00:00:00

  • Colloidal gas aphrons: potential applications in biotechnology

    abstract::Colloidal gas aphrons are microbubbles encapsulated by surfactant multilayers. They provide a large interfacial area to adsorb charged and/or hydrophobic molecules; the extent and mechanism of the adsorption depends on the surfactant multilayer. The physical properties of colloidal gas aphrons have recently been chara...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Jauregi P,Varley J

    更新日期:1999-10-01 00:00:00

  • Technology and fear: is wonder the key?

    abstract::Technology is a social practice that embodies the capacity of societies to transform themselves by creating and manipulating not only physical objects, but also symbols and cultural forms. It is an illusion that scientific and socioeconomic drivers are the sole elements determining the destiny of a technology. Althoug...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Mordini E

    更新日期:2007-12-01 00:00:00

  • Transgenic plants as vaccine production systems.

    abstract::Transgenic plants that express foreign proteins with industrial or pharmaceutical value represent an economical alternative to fermentation-based production systems. Specific vaccines have been produced in plants as a result of the transient or stable expression of foreign genes. It has recently been shown that genes ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Mason HS,Arntzen CJ

    更新日期:1995-09-01 00:00:00

  • The Tortoise and the Hare: Evolving Regulatory Landscapes for Biosimilars.

    abstract::Challenges in demonstrating interchangeability and safety, as well as the ongoing evolution of regulations governing biosimilars, have meant that the development of the biosimilars industry has not been, and will not be, a carbon copy of the generics industry. Complexity in the development process reduces the cost adv...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Konara CS,Barnard RT,Hine D,Siegel E,Ferro V

    更新日期:2016-01-01 00:00:00

  • Combinatorial biocatalysis: a natural approach to drug discovery.

    abstract::Nature's most potent molecules are produced by enzyme-catalysed reactions, coupled with the natural selection of those products that possess optimal biological activity. Combinatorial biocatalysis harnesses the natural diversity of enzymatic reactions for the iterative synthesis of organic libraries. Iterative reactio...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Michels PC,Khmelnitsky YL,Dordick JS,Clark DS

    更新日期:1998-05-01 00:00:00

  • Microdroplet-Assisted Screening of Biomolecule Production for Metabolic Engineering Applications.

    abstract::Success in synthetic biology and metabolic engineering is quickly becoming 'test' limited within the design-build-test cycle. Commonly used methods for high-throughput screening, including fluorescence-activated cell sorting (FACS) and microtiter plates, have intracellular product and throughput limitations. A growing...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Bowman EK,Alper HS

    更新日期:2020-07-01 00:00:00

  • Alginate as immobilization matrix for cells.

    abstract::In recent years, entrapment of cells within spheres of Ca2+ alginate has become the most widely used technique for immobilizing living cells. This versatile method includes applications ranging from immobilization of living or dead cells in bioreactors, immobilization of plant protoplasts for micropropagation and immo...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Smidsrød O,Skjåk-Braek G

    更新日期:1990-03-01 00:00:00

  • The Glass Menagerie: diatoms for novel applications in nanotechnology.

    abstract::Diatoms are unicellular, eukaryotic, photosynthetic algae that are found in aquatic environments. Diatoms have enormous ecological importance on this planet and display a diversity of patterns and structures at the nano- to millimetre scale. Diatom nanotechnology, a new interdisciplinary area, has spawned collaboratio...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Gordon R,Losic D,Tiffany MA,Nagy SS,Sterrenburg FA

    更新日期:2009-02-01 00:00:00

  • Microbial Factories for the Production of Benzylisoquinoline Alkaloids.

    abstract::Benzylisoquinoline alkaloids (BIAs) are a family of ∼2500 alkaloids with both potential and realized pharmaceutical value, including most notably the opiates such as codeine and morphine. Only a few BIAs accumulate readily in plants, which limits the pharmaceutical potential of the family. Shifting BIA production to m...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Narcross L,Fossati E,Bourgeois L,Dueber JE,Martin VJJ

    更新日期:2016-03-01 00:00:00

  • Neuroimaging-based approaches in the brain-computer interface.

    abstract::Techniques to enable direct communication between the brain and computers/machines, such as the brain-computer interface (BCI) or the brain-machine interface (BMI), are gaining momentum in the neuroscientific realm, with potential applications ranging from medicine to general consumer electronics. Noninvasive BCI tech...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Min BK,Marzelli MJ,Yoo SS

    更新日期:2010-11-01 00:00:00

  • The status of membrane bioreactor technology.

    abstract::In this article, the current status of membrane bioreactor (MBR) technology for wastewater treatment is reviewed. Fundamental facets of the MBR process and membrane and process configurations are outlined and the advantages and disadvantages over conventional suspended growth-based biotreatment are briefly identified....

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Judd S

    更新日期:2008-02-01 00:00:00

  • Antibody separation by hydrophobic charge induction chromatography.

    abstract::Hydrophobic charge induction chromatography using 4-mercapto-ethyl-pyridine as the ligand is an effective method for the separation of antibodies from a variety of feedstocks. Antibodies are adsorbed in physiological conditions without preliminary concentration. Desorption occurs when the pH is lowered, thus inducing ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Boschetti E

    更新日期:2002-08-01 00:00:00

  • Phase and antigenic variation--the impact on strategies for bacterial vaccine design.

    abstract::Many pathogens have the ability to vary the antigenic composition of surface-associated antigens. Often, this variation is mediated by the regulation of gene expression. By varying its antigenicity, the pathogen is able to avoid host immune responses more efficiently; however, this makes the design of vaccines against...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Maskell D,Frankel G,Dougan G

    更新日期:1993-12-01 00:00:00

  • The myth of the biotech revolution.

    abstract::The existence of a medicinal 'biotech revolution' has been widely accepted and promoted by academics, consultants, industry and government. This has generated expectations about significant improvements in the drug discovery process, healthcare and economic development that influence a considerable amount of policy-ma...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Nightingale P,Martin P

    更新日期:2004-11-01 00:00:00

  • Semiconductor quantum dots for in vitro diagnostics and cellular imaging.

    abstract::The need for companion diagnostics, point-of-care testing (POCT) and high-throughput screening in clinical diagnostics and personalized medicine has pushed the need for more biological information from a single sample at extremely low concentrations and volumes. Optical biosensors based on semiconductor quantum dots (...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Jin Z,Hildebrandt N

    更新日期:2012-07-01 00:00:00

  • Varying virulence: epigenetic control of expression noise and disease processes.

    abstract::Gene expression noise is a significant source of phenotypic heterogeneity in otherwise identical populations of cells. Phenotypic heterogeneity can cause reversible drug resistance in diseased cells, and thus a better understanding of its origins might improve treatment strategies. In eukaryotes, data strongly suggest...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Miller-Jensen K,Dey SS,Schaffer DV,Arkin AP

    更新日期:2011-10-01 00:00:00

  • Can Bottom-Up Synthetic Biology Generate Advanced Drug-Delivery Systems?

    abstract::Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which relies on the use of nanotechnologies to fight disease, was envisaged to fulfill this coveted goal. Despite substantial progress, the struc...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Lussier F,Staufer O,Platzman I,Spatz JP

    更新日期:2020-09-07 00:00:00

  • Enzymes as Green Catalysts and Interactive Biomolecules in Wound Dressing Hydrogels.

    abstract::Hydrogels are 3D hydrophilic polymer networks that absorb and hold huge amounts of water. Although hydrogels have traditionally been synthesized using chemical and physical methods, rapid developments in enzyme technology that, like chemical-based methods, enable the formation of stable covalent bonds are fast emergin...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Guebitz GM,Nyanhongo GS

    更新日期:2018-10-01 00:00:00