The Post-genomic Era of Trichoderma reesei: What's Next?

Abstract:

:The ascomycete Trichoderma reesei is one of the most well studied cellulolytic microorganisms. This fungus is widely used in the biotechnology industry, mainly in the production of biofuels. Due to its importance, its genome was sequenced in 2008, opening new avenues to study this microorganism. In this 'post-genomic' era, a transcriptomic and proteomic era has emerged. Here, we present an overview of new findings in the gene expression regulation network of T. reesei. We also discuss new rational strategies to obtain mutants that produce hydrolytic enzymes with a higher yield, using metabolic engineering. Finally, we present how synthetic biology strategies can be used to create engineered promoters to efficiently synthesize enzymes for biomass degradation to produce bioethanol.

journal_name

Trends Biotechnol

journal_title

Trends in biotechnology

authors

Gupta VK,Steindorff AS,de Paula RG,Silva-Rocha R,Mach-Aigner AR,Mach RL,Silva RN

doi

10.1016/j.tibtech.2016.06.003

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

970-982

issue

12

eissn

0167-7799

issn

1879-3096

pii

S0167-7799(16)30085-3

journal_volume

34

pub_type

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