Abstract：
:Antimicrobial resistance (AMR) has developed into a huge threat to global health, and reducing it is an urgent priority for public health authorities. The importance of a healthy and balanced gut microbiome has been identified as a key protective factor against AMR development, but this can be significantly affected by antibiotic therapy, resulting in dysbiosis and reduction of taxonomic richness. The way in which antibiotics are administered could form an important part of future antimicrobial stewardship strategies, where drug delivery is ideally placed to play a key role in the fight against AMR. This review focuses on drug delivery strategies for antibiotic administration, including avoidance of the gut microbiome and targeted delivery approaches, which may reduce AMR.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Kelly SA,Rodgers AM,O'Brien SC,Donnelly RF,Gilmore BFdoi
10.1016/j.tibtech.2019.10.008subject
Has Abstractpub_date
2020-04-01 00:00:00pages
447-462issue
4eissn
0167-7799issn
1879-3096pii
S0167-7799(19)30249-5journal_volume
38pub_type
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