Abstract:
:Low production cost is a key factor driving the development of plants and plant tissue cultures for the synthesis of therapeutic and other foreign proteins. Because product yield and concentration exert a major influence on process economics, improving foreign protein accumulation is crucial for enhancing the commercial success of plant-based production systems. Strategies aimed at increasing transgene expression have been effective; however, a critical but poorly understood factor contributing to low foreign protein yield is post-synthesis and/or post-secretion instability and degradation. Loss of foreign protein as result of biological and physical processes such as proteolytic destruction and irreversible surface adsorption can occur in plants and plant culture systems. This review highlights the need to consider such mechanisms and outlines a range of remedial strategies aimed at minimizing foreign protein degradation and loss.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Doran PMdoi
10.1016/j.tibtech.2006.06.012subject
Has Abstractpub_date
2006-09-01 00:00:00pages
426-32issue
9eissn
0167-7799issn
1879-3096pii
S0167-7799(06)00161-2journal_volume
24pub_type
杂志文章,评审abstract::Anywhere water is in the liquid state, bacteria will exist as biofilms, which are complex communities of cells that are cemented together. Although frequently associated with disease and biofouling, biofilms are also important for engineering applications, such as bioremediation, biocatalysis and microbial fuel cells....
journal_title:Trends in biotechnology
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abstract::Research infrastructures are essential for top-level academic and industrial research activities. Throughout the successive framework programmes (FPs) of the EU, actions have been gradually developed to support researchers in accessing top-level European research infrastructures located outside their own country and a...
journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2007.03.001
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abstract::We discuss the general properties of optical imaging in three-dimensional object domains from an information-theoretic standpoint, expressing system performance in terms of imaging mutual information (IMI). We use IMI to characterize volume holographic imaging, a new optical imaging method with depth discrimination ca...
journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2003.08.006
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2009.11.004
更新日期:2010-02-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/s0167-7799(01)01701-2
更新日期:2001-09-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章
doi:10.1016/j.tibtech.2013.10.009
更新日期:2014-01-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2020.07.003
更新日期:2020-08-14 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2012.04.005
更新日期:2012-07-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章
doi:10.1016/s0167-7799(00)01482-7
更新日期:2000-09-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2008.02.009
更新日期:2008-06-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章
doi:10.1016/j.tibtech.2004.07.004
更新日期:2004-09-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/S0167-7799(97)01077-9
更新日期:1997-11-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2004.12.003
更新日期:2005-02-01 00:00:00
abstract::The BRICS countries (Brazil, Russia, India, China, South Africa) account for 25% of global biotechnology patents. To understand the current and future landscape of the domain, it is important to better understand the capacity of these contributors. Here, we consider the thematic priorities, strategies, and key players...
journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
pub_type: 杂志文章
doi:10.1016/j.tibtech.2019.09.003
更新日期:2019-11-01 00:00:00
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journal_title:Trends in biotechnology
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doi:10.1016/s0167-7799(98)01209-8
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journal_title:Trends in biotechnology
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doi:10.1016/j.tibtech.2011.01.005
更新日期:2011-05-01 00:00:00
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journal_title:Trends in biotechnology
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更新日期:2002-04-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
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更新日期:1995-11-01 00:00:00
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journal_title:Trends in biotechnology
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更新日期:2012-11-01 00:00:00
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journal_title:Trends in biotechnology
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doi:10.1016/0167-7799(96)10038-X
更新日期:1996-08-01 00:00:00
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journal_title:Trends in biotechnology
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更新日期:2014-06-01 00:00:00
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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doi:10.1016/j.tibtech.2010.04.004
更新日期:2010-07-01 00:00:00
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