Biomimetic approaches to protein and gene delivery for tissue regeneration.


:Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues. Many synthetic or natural biomaterials have been developed for this purpose and are used to deliver wound therapeutics in a controlled manner that prevents unwanted and potentially harmful side-effects. Here, we review the natural and synthetic biomaterials that have been developed for protein and gene delivery to enhance tissue regeneration. Particular emphasis is placed on novel biomimetic materials that respond to environmental stimuli or release their cargo according to cellular demand. Engineering biomaterials to release therapeutic agents in response to physiologic signals mimics the natural healing process and can promote faster tissue regeneration and reduce scarring in severe acute or chronic wounds.


Trends Biotechnol


Trends in biotechnology


Andreadis ST,Geer DJ




Has Abstract


2006-07-01 00:00:00














  • Commercialization of microfluidic devices.

    abstract::Microfluidic devices offer automation and high-throughput screening, and operate at low volumes of consumables. Although microfluidics has the potential to reduce turnaround times and costs for analytical devices, particularly in medical, veterinary, and environmental sciences, this enabling technology has had limited...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Volpatti LR,Yetisen AK

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  • Protein-protein docking: is the glass half-full or half-empty?

    abstract::Are current docking methods capable of building complexes from putative component protein structures? Results of recent computational studies, including those of the CAPRI (Critical Assessment of Protein Interactions) competition, were used to determine the key properties for successful docking and introduce a classif...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Vajda S,Camacho CJ

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  • Synthetic biology, the bioeconomy, and a societal quandary.

    abstract::Opinions on what synthetic biology actually is range from a natural extension of genetic engineering to a new manufacturing paradigm. It offers, for the first time in the life sciences, rational design and engineering standardisation. It could address problems across a broad spectrum of human concerns, including energ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Philp JC,Ritchie RJ,Allan JE

    更新日期:2013-05-01 00:00:00

  • Glowing jellyfish, luminescence and a molecule called coelenterazine.

    abstract::Luminescence has assumed an important role in analytical biochemistry and molecular biology as an extremely sensitive method for determining the concentration of specific ions and molecules. The luminescent system of the jellyfish Aequorea victoria consists of the photoprotein aequorin, which contains the molecule coe...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Jones K,Hibbert F,Keenan M

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  • Applications of pHLIP Technology for Cancer Imaging and Therapy.

    abstract::Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, such as antibody targeting. The pH (low) insertion peptides (pHLIP®s) provide new opportunities for targeting acidic tissues. Through the physical mechanism of membran...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Wyatt LC,Lewis JS,Andreev OA,Reshetnyak YK,Engelman DM

    更新日期:2017-07-01 00:00:00

  • Reconstituted viral envelopes--'Trojan horses' for drug delivery and gene therapy?

    abstract::Reconstituted viral envelopes (RVEs) are formed by solubilizing intact virus in detergent and reassembling the envelope on removal of detergent. RVEs can be formed in the presence of agents that become encapsulated and can then be utilized in vitro and in vivo for drug delivery, cell destruction, transfer of membrane ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Blumenthal R,Loyter A

    更新日期:1991-02-01 00:00:00

  • Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis.

    abstract::Stem cell differentiation is regulated by the complex interplay of multiple parameters, including adhesive intercellular interactions, cytoskeletal and extracellular matrix remodeling, and gradients of agonists and antagonists that individually and collectively vary as a function of spatial locale and temporal stages ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Kinney MA,McDevitt TC

    更新日期:2013-02-01 00:00:00

  • Angels and Devils: Dilemmas in Dual-Use Biotechnology.

    abstract::Dual-use research, which results in knowledge that can be used for both good and ill, has become increasingly accessible in the internet age to both scientists and the general public. Here, we outline some major milestones for dual-use policy and present three vignettes that highlight contemporary dual-use issues in b...

    journal_title:Trends in biotechnology

    pub_type: 历史文章,杂志文章


    authors: Getz LJ,Dellaire G

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  • Towards a 'universal' nucleant for protein crystallization.

    abstract::The expression 'crystal clear' stems from the science of crystallography, which determines the detailed atomic structures of materials by exposing crystals to X-rays. Protein structures are pivotal to the success of rational drug design and other biotechnology applications; however, obtaining high quality crystals pos...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Saridakis E,Chayen NE

    更新日期:2009-02-01 00:00:00

  • Nanosilver as a new generation of nanoproduct in biomedical applications.

    abstract::Nanosilver (NS), comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that NS has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Chaloupka K,Malam Y,Seifalian AM

    更新日期:2010-11-01 00:00:00

  • Bioencapsulation within synthetic polymers (Part 1): sol-gel encapsulated biologicals.

    abstract::Since its inception a decade ago, sol-gel encapsulation has opened up an intriguing new way to immobilize biological materials. An array of substances, including catalytic antibodies, DNA, RNA, antigens, live bacterial, fungal, plant and animal cells and whole protozoa, have been encapsulated in silica, metal-oxide, o...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Gill I,Ballesteros A

    更新日期:2000-07-01 00:00:00

  • The myth of the biotech revolution.

    abstract::The existence of a medicinal 'biotech revolution' has been widely accepted and promoted by academics, consultants, industry and government. This has generated expectations about significant improvements in the drug discovery process, healthcare and economic development that influence a considerable amount of policy-ma...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Nightingale P,Martin P

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  • Metabolic footprinting in microbiology: methods and applications in functional genomics and biotechnology.

    abstract::Metabolomics embraces several strategies that aim to quantify cell metabolites in order to increase our understanding of how metabolite levels and interactions influence phenotypes. Metabolic footprinting represents a niche within metabolomics, because it focuses on the analysis of extracellular metabolites. Although ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Mapelli V,Olsson L,Nielsen J

    更新日期:2008-09-01 00:00:00

  • Bioelectrochemical Power-to-Gas: State of the Art and Future Perspectives.

    abstract::Bioelectrochemical power-to-gas (BEP2G) is considered a potentially convenient way of storing renewable surplus electricity in the form of methane. In methane-producing bioelectrochemical systems (BESs), carbon dioxide and electrical energy are converted into methane, using electrodes that supply either electrons or h...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Geppert F,Liu D,van Eerten-Jansen M,Weidner E,Buisman C,Ter Heijne A

    更新日期:2016-11-01 00:00:00

  • Designing and optimizing library selection strategies for generating high-affinity antibodies.

    abstract::Since its invention at the beginning of the 1990s, antibody phage display has revolutionized the generation of monoclonal antibodies and their engineering. It is now possible to create antibodies binding to any chosen target antigen without the use of laboratory animals or hybridomas, in a system that completely by-pa...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Hoogenboom HR

    更新日期:1997-02-01 00:00:00

  • Monitoring the efficacy of bioremediation.

    abstract::The general acceptance of bioremediation technology as an environmentally sound and economic treatment for hazardous waste requires the demonstration of its efficacy, reliability and predictability, as well as its advantages over conventional treatments. An effective monitoring design includes protocols for treatment-...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Heitzer A,Sayler GS

    更新日期:1993-08-01 00:00:00

  • FTIR microspectroscopy for improved prostate cancer diagnosis.

    abstract::Accurate diagnosis and prognosis is essential for cancer management but is subject to sampling and inter-observer error. In a recent study, Baker et al. compared Fourier transform infrared (FTIR) microspectroscopy with histological pathology to evaluate prostate tissue for disease severity. The authors found that bioc...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Mackanos MA,Contag CH

    更新日期:2009-12-01 00:00:00

  • Vibrational spectroscopy in stem cell characterisation: is there a niche?

    abstract::Vibrational spectroscopy using both infrared and Raman spectroscopies has been used in recent years with the aim to aid clinicians in disease diagnosis. More recently, these techniques have been applied to study stem cell differentiation and to determine stem cell presence in tissues. These studies have demonstrated t...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Sulé-Suso J,Forsyth NR,Untereiner V,Sockalingum GD

    更新日期:2014-05-01 00:00:00

  • Rethinking production of Taxol® (paclitaxel) using endophyte biotechnology.

    abstract::Taxol® (generic name paclitaxel) represents one of the most clinically valuable natural products known to mankind in the recent past. More than two decades have elapsed since the notable discovery of the first Taxol®-producing endophytic fungus, which was followed by a plethora of reports on other endophytes possessin...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Kusari S,Singh S,Jayabaskaran C

    更新日期:2014-06-01 00:00:00

  • Learning from Nature to Expand the Genetic Code.

    abstract::The genetic code is the manual that cells use to incorporate amino acids into proteins. It is possible to artificially expand this manual through cellular, molecular, and chemical manipulations to improve protein functionality. Strategies for in vivo genetic code expansion are under the same functional constraints as ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Ros E,Torres AG,Ribas de Pouplana L

    更新日期:2020-09-04 00:00:00

  • The Tortoise and the Hare: Evolving Regulatory Landscapes for Biosimilars.

    abstract::Challenges in demonstrating interchangeability and safety, as well as the ongoing evolution of regulations governing biosimilars, have meant that the development of the biosimilars industry has not been, and will not be, a carbon copy of the generics industry. Complexity in the development process reduces the cost adv...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Konara CS,Barnard RT,Hine D,Siegel E,Ferro V

    更新日期:2016-01-01 00:00:00

  • Potential of siderophore-producing bacteria for improving heavy metal phytoextraction.

    abstract::Phytoremediation holds promise for in situ treatment of heavy metal contaminated soils. Recently, the benefits of combining siderophore-producing bacteria (SPB) with plants for metal removal from contaminated soils have been demonstrated. Metal-resistant SPB play an important role in the successful survival and growth...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Rajkumar M,Ae N,Prasad MN,Freitas H

    更新日期:2010-03-01 00:00:00

  • Advances in Dental Materials through Nanotechnology: Facts, Perspectives and Toxicological Aspects.

    abstract::Nanotechnology is currently driving the dental materials industry to substantial growth, thus reflecting on improvements in materials available for oral prevention and treatment. The present review discusses new developments in nanotechnology applied to dentistry, focusing on the use of nanomaterials for improving the...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Padovani GC,Feitosa VP,Sauro S,Tay FR,Durán G,Paula AJ,Durán N

    更新日期:2015-11-01 00:00:00

  • Antibody separation by hydrophobic charge induction chromatography.

    abstract::Hydrophobic charge induction chromatography using 4-mercapto-ethyl-pyridine as the ligand is an effective method for the separation of antibodies from a variety of feedstocks. Antibodies are adsorbed in physiological conditions without preliminary concentration. Desorption occurs when the pH is lowered, thus inducing ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Boschetti E

    更新日期:2002-08-01 00:00:00

  • Using Prokaryotes for Carbon Capture Storage.

    abstract::Geological storage of CO2 is a fast-developing technology that can mitigate rising carbon emissions. However, there are environmental concerns with the long-term storage and implications of a leak from a carbon capture storage (CCS) site. Traditional monitoring lacks clear protocols and relies heavily on physical meth...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Hicks N,Vik U,Taylor P,Ladoukakis E,Park J,Kolisis F,Jakobsen KS

    更新日期:2017-01-01 00:00:00

  • Scientific Citizenship and good governance: implications for biotechnology.

    abstract::In the wake of public distrust regarding biotechnology, it has been suggested that the debate should be moved "upstream", whereby the public help to set research priorities. Although many scientists see this as an illogical reaction to a loss of faith in science, we argue that the boundaries between science and its te...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Davies KG,Wolf-Phillips J

    更新日期:2006-02-01 00:00:00

  • Platforms for enrichment of phosphorylated proteins and peptides in proteomics.

    abstract::Protein phosphorylation is a complex and highly dynamic process involved in numerous biological events. Abnormal phosphorylation is one of the underlying mechanisms for the development of cancer and metabolic disorders. The identification and absolute quantification of specific phospho-signatures can help elucidate pr...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Batalha IL,Lowe CR,Roque AC

    更新日期:2012-02-01 00:00:00

  • Imaging techniques in the analysis of brain function and behaviour.

    abstract::Techniques such as positron-emission tomography, single-photon-emission computed tomography, functional magnetic-resonance imaging and magnetoencephalography permit the observation of biological processes in the brain in a noninvasive manner. They have yielded new insights into the biological interrelations of sensory...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Müller-Gärtner HW

    更新日期:1998-03-01 00:00:00

  • Harnessing SLE Autoantibodies for Intracellular Delivery of Biologic Therapeutics.

    abstract::Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for biomedical research and the pharmaceutical industry. Approximately two-thirds of disease-associated targets are found inside the cell. Difficulty blocking these targets with available drugs creates a need for technology to...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Gordon RE,Nemeth JF,Singh S,Lingham RB,Grewal IS

    更新日期:2020-08-14 00:00:00

  • Promises and pitfalls of synthetic chromosomes in plants.

    abstract::This review summarizes synthetic chromosome construction in plants and speculates on how they might be applied to various uses in the future, as well as the possible impact for synthetic biology. The procedures to construct foundational platforms for synthetic chromosomes in plants are described, together with some ch...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Birchler JA

    更新日期:2015-03-01 00:00:00