Biomimetic approaches to protein and gene delivery for tissue regeneration.

Abstract:

:Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues. Many synthetic or natural biomaterials have been developed for this purpose and are used to deliver wound therapeutics in a controlled manner that prevents unwanted and potentially harmful side-effects. Here, we review the natural and synthetic biomaterials that have been developed for protein and gene delivery to enhance tissue regeneration. Particular emphasis is placed on novel biomimetic materials that respond to environmental stimuli or release their cargo according to cellular demand. Engineering biomaterials to release therapeutic agents in response to physiologic signals mimics the natural healing process and can promote faster tissue regeneration and reduce scarring in severe acute or chronic wounds.

journal_name

Trends Biotechnol

journal_title

Trends in biotechnology

authors

Andreadis ST,Geer DJ

doi

10.1016/j.tibtech.2006.05.001

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

331-7

issue

7

eissn

0167-7799

issn

1879-3096

pii

S0167-7799(06)00124-7

journal_volume

24

pub_type

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