Abstract:
:Attempts through somatic cell nuclear transfer to expand wild populations that have shrunk to critical numbers is a logical extension of the successful cloning of mammals. However, although the first mammal was cloned 10 years ago, nuclear reprogramming remains phenomenological, with abnormal gene expression and epigenetic deregulation being associated with the cloning process. In addition, although cloning of wild animals using host oocytes from different species has been successful, little is known about the implication of partial or total mitochondrial DNA heteroplasmy in cloned embryos, fetuses and offspring. Finally, there is a need for suitable foster mothers for inter-intra specific cloned embryos. Considering these issues, the limited success achieved in cloning endangered animals is not surprising. However, optimism comes from the rapid gain in the understanding of the molecular clues underlying nuclear reprogramming. If it is possible to achieve a controlled reversal of the differentiated state of a cell then it is probable that other issues that impair the cloning of endangered animals, such as the inter-intra species oocyte or womb donor, will be overcome in the medium term.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Loi P,Galli C,Ptak Gdoi
10.1016/j.tibtech.2007.03.007subject
Has Abstractpub_date
2007-05-01 00:00:00pages
195-200issue
5eissn
0167-7799issn
1879-3096pii
S0167-7799(07)00078-9journal_volume
25pub_type
杂志文章,评审abstract::We have isolated several microorganisms that are adapted to living in the extremes of the deep-sea environment. They include barophilic bacteria, which are able to grow at high hydrostatic pressure, but that are unable to grow at atmospheric pressure, and organic-solvent-tolerant bacteria, which are able to grow in th...
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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pub_type: 杂志文章,评审
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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更新日期:2001-10-01 00:00:00
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journal_title:Trends in biotechnology
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doi:10.1016/j.tibtech.2014.03.007
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2007.09.001
更新日期:2007-10-01 00:00:00
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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