Abstract:
:The promising recognition characteristics exhibited by biomolecules have caused significant interest in biomolecule-based sensor strategies. Here we review several emerging biosensor designs that use modulated electron or energy transfer to a bio-specific ligand as the signaling mechanism. The efficiencies of both electron transfer and energy transfer are strongly dependent on donor-acceptor distance. When coupled with the large conformational changes sometimes associated with biomolecular recognition, these distance-dependent processes provide a robust means for generating optical and electronic signals.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Fan C,Plaxco KW,Heeger AJdoi
10.1016/j.tibtech.2005.02.005subject
Has Abstractpub_date
2005-04-01 00:00:00pages
186-92issue
4eissn
0167-7799issn
1879-3096pii
S0167-7799(05)00051-Xjournal_volume
23pub_type
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