European research infrastructures for the development of nanobiotechnologies.

Abstract:

:Research infrastructures are essential for top-level academic and industrial research activities. Throughout the successive framework programmes (FPs) of the EU, actions have been gradually developed to support researchers in accessing top-level European research infrastructures located outside their own country and also to better coordinate and integrate these infrastructures Europe-wide, enabling better research services. At the same time, research infrastructures pave the way for the development of scientific and technological advances. Under the sixth Framework Programme (FP6; 2002-2006), for example, nanobiotechnologies have benefited from these European actions through three approaches: the support of multi-disciplinary pan-European infrastructures; the support of pan-European infrastructures dedicated to biology but with usage in multiple domains of biology; and the funding of integrated centers for nanobiotechnologies. The seventh Framework Programme (FP7; 2007-2013) will reinforce these actions toward research infrastructures, with particular attention to the emergence of new ones as well as to the provision of important strategic research services in fields such as nanobiotechnologies.

journal_name

Trends Biotechnol

journal_title

Trends in biotechnology

authors

Péro H,Faure JE

doi

10.1016/j.tibtech.2007.03.001

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

191-4

issue

5

eissn

0167-7799

issn

1879-3096

pii

S0167-7799(07)00072-8

journal_volume

25

pub_type

杂志文章,评审
  • Non-GMO genetically edited crop plants.

    abstract::Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2015.04.002

    authors: Kanchiswamy CN,Malnoy M,Velasco R,Kim JS,Viola R

    更新日期:2015-09-01 00:00:00

  • Biosensors based on binding-modulated donor-acceptor distances.

    abstract::The promising recognition characteristics exhibited by biomolecules have caused significant interest in biomolecule-based sensor strategies. Here we review several emerging biosensor designs that use modulated electron or energy transfer to a bio-specific ligand as the signaling mechanism. The efficiencies of both ele...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2005.02.005

    authors: Fan C,Plaxco KW,Heeger AJ

    更新日期:2005-04-01 00:00:00

  • Regulation of Glucose Metabolism - A Perspective From Cell Bioprocessing.

    abstract::Cultured mammalian cells are the main workhorses for producing biologics. The performance of these cell culture processes, in terms of both productivity and product quality attributes, is significantly influenced by cellular metabolism. Glucose is the major carbon source for cellular biosynthesis and energy generation...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2016.04.012

    authors: Mulukutla BC,Yongky A,Le T,Mashek DG,Hu WS

    更新日期:2016-08-01 00:00:00

  • Probiotics in transition: novel strategies.

    abstract::Regulations regarding health claims made for probiotics demand their proven effectiveness and limit the array of microbial species regarded as safe for live consumption. Novel strategies such as moving to postbiotics and genetically modified probiotics may be necessary to increase the effectiveness of microbial produc...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2015.01.006

    authors: Gosálbez L,Ramón D

    更新日期:2015-04-01 00:00:00

  • Tumor targeting: activation of prodrugs by enzyme-monoclonal antibody conjugates.

    abstract::Selective delivery of lethal levels of drugs to tumors, without concomitant damage to normal tissues, is a major challenge in cancer chemotherapy. Prodrugs used in conjunction with enzyme-monoclonal antibody conjugates that can target tumors and convert prodrugs to their active drug forms in situ, offer exceptional pr...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/0167-7799(94)90122-8

    authors: Huennekens FM

    更新日期:1994-06-01 00:00:00

  • Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective.

    abstract::Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) components in an important interface whose correct functioning is crit...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2018.01.003

    authors: Potjewyd G,Moxon S,Wang T,Domingos M,Hooper NM

    更新日期:2018-04-01 00:00:00

  • β-Lactam and glycopeptide antibiotics: first and last line of defense?

    abstract::Most infections are caused by bacteria, many of which are ever-evolving and resistant to nearly all available antibiotics. β-Lactams and glycopeptides are used to combat these infections by inhibiting bacterial cell-wall synthesis. This mechanism remains an interesting target in the search for new antibiotics in light...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2010.09.004

    authors: Jovetic S,Zhu Y,Marcone GL,Marinelli F,Tramper J

    更新日期:2010-12-01 00:00:00

  • Malaria transmission-blocking vaccines.

    abstract::Antibodies to surface proteins of the sexual stages of Plasmodium falciparum block completely the transmission of these malaria parasites. Transmission-blocking vaccines therefore represent a powerful and novel approach to controlling the spread of this lethal disease. ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/0167-7799(92)90280-9

    authors: Kaslow DC,Bathurst IC,Barr PJ

    更新日期:1992-11-01 00:00:00

  • Harnessing SLE Autoantibodies for Intracellular Delivery of Biologic Therapeutics.

    abstract::Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for biomedical research and the pharmaceutical industry. Approximately two-thirds of disease-associated targets are found inside the cell. Difficulty blocking these targets with available drugs creates a need for technology to...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2020.07.003

    authors: Gordon RE,Nemeth JF,Singh S,Lingham RB,Grewal IS

    更新日期:2020-08-14 00:00:00

  • How omics technologies can contribute to the '3R' principles by introducing new strategies in animal testing.

    abstract::In Europe, in light of ethical, political and commercial pressure, every effort should be made to replace animals with alternatives (e.g. in vitro models), to reduce the number of animals used in experiments to a minimum and to refine current testing strategies in a way that ensures animals undergo minimum pain and di...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2006.06.003

    authors: Kroeger M

    更新日期:2006-08-01 00:00:00

  • Genomics-Driven Natural Product Discovery in Actinomycetes.

    abstract::The prevalence of antimicrobial-resistant pathogens has highlighted the urgent need for new drugs. Actinomycetes have been the most prominent sources of natural products for drug discovery and development. Advances in genomics have inspired several emerging strategies to reinvigorate the field of natural product disco...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2017.10.009

    authors: Niu G

    更新日期:2018-03-01 00:00:00

  • The myth of the biotech revolution.

    abstract::The existence of a medicinal 'biotech revolution' has been widely accepted and promoted by academics, consultants, industry and government. This has generated expectations about significant improvements in the drug discovery process, healthcare and economic development that influence a considerable amount of policy-ma...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2004.09.010

    authors: Nightingale P,Martin P

    更新日期:2004-11-01 00:00:00

  • Novel and established applications of microbial polysaccharides.

    abstract::Microbial exopolysaccharides such as xanthan and dextran have been commercial products for many years; the search for new gelling agents has yielded gellan. Exopolysaccharides have many other novel properties to offer, and the discovery of immune modulation and tumouristasis by beta-D-glucans, and the use of bacterial...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/S0167-7799(97)01139-6

    authors: Sutherland IW

    更新日期:1998-01-01 00:00:00

  • Delivery of intrahemocoelic peptides for insect pest management.

    abstract::The extensive use of chemical insecticides for insect pest management has resulted in insecticide resistance now being recorded in >500 species of insects and mites. Although gut-active toxins such as those derived from Bacillus thuringiensis (Bt) have been successfully used for insect pest management, a diverse range...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2013.08.001

    authors: Bonning BC,Chougule NP

    更新日期:2014-02-01 00:00:00

  • Unearthing Hidden Chemical Potential from Discarded Actinobacterial Libraries.

    abstract::The redundancy of natural product biosynthesis in microbes poses a practical challenge for discovering new antimicrobial compounds from bacteria. The recent application of clustered regularly interspaced short palindromic repeats (CRISPR) technology by Culp et al. to inactivate the production of abundant antibiotics g...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2019.11.003

    authors: Timmermans ML,Ross AC

    更新日期:2020-01-01 00:00:00

  • Detecting single-base mutations.

    abstract::The ability to detect single-base changes is of fundamental importance in molecular genetics. This is particularly true in human genetics, where interest in linking mutations of identified genes to particular disease phenotypes is most intense, and where a demand exists for clinical diagnosis of defined mutations. In ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/0167-7799(93)90135-V

    authors: Prosser J

    更新日期:1993-06-01 00:00:00

  • Autonomous surveillance for biosecurity.

    abstract::The global movement of people and goods has increased the risk of biosecurity threats and their potential to incur large economic, social, and environmental costs. Conventional manual biosecurity surveillance methods are limited by their scalability in space and time. This article focuses on autonomous surveillance sy...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2015.01.003

    authors: Jurdak R,Elfes A,Kusy B,Tews A,Hu W,Hernandez E,Kottege N,Sikka P

    更新日期:2015-04-01 00:00:00

  • Using Prokaryotes for Carbon Capture Storage.

    abstract::Geological storage of CO2 is a fast-developing technology that can mitigate rising carbon emissions. However, there are environmental concerns with the long-term storage and implications of a leak from a carbon capture storage (CCS) site. Traditional monitoring lacks clear protocols and relies heavily on physical meth...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/j.tibtech.2016.06.011

    authors: Hicks N,Vik U,Taylor P,Ladoukakis E,Park J,Kolisis F,Jakobsen KS

    更新日期:2017-01-01 00:00:00

  • Foreign protein degradation and instability in plants and plant tissue cultures.

    abstract::Low production cost is a key factor driving the development of plants and plant tissue cultures for the synthesis of therapeutic and other foreign proteins. Because product yield and concentration exert a major influence on process economics, improving foreign protein accumulation is crucial for enhancing the commerci...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2006.06.012

    authors: Doran PM

    更新日期:2006-09-01 00:00:00

  • Rapid prototyping as a tool for manufacturing bioartificial livers.

    abstract::Rapid prototyping (RP) technologies are a set of manufacturing processes that can produce very complex structures directly from computer-aided design models without structure-specific tools or knowledge. These technologies might eventually enable the manufacture of human livers to create functional substitutes for tre...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2007.08.010

    authors: Wang X,Yan Y,Zhang R

    更新日期:2007-11-01 00:00:00

  • Potential of siderophore-producing bacteria for improving heavy metal phytoextraction.

    abstract::Phytoremediation holds promise for in situ treatment of heavy metal contaminated soils. Recently, the benefits of combining siderophore-producing bacteria (SPB) with plants for metal removal from contaminated soils have been demonstrated. Metal-resistant SPB play an important role in the successful survival and growth...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2009.12.002

    authors: Rajkumar M,Ae N,Prasad MN,Freitas H

    更新日期:2010-03-01 00:00:00

  • Enzyme reactions in the presence of cyclodextrins: biosensors and enzyme assays.

    abstract::Cyclodextrins, macrocyclic carbohydrates with apolar internal cavities, can form complexes with, and solubilize many normally water-insoluble compounds. Ferrocene and its derivatives, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/S0167-7799(00)89002-2

    authors: Luong JH,Brown RS,Male KB,Cattaneo MV,Zhao S

    更新日期:1995-11-01 00:00:00

  • Computational design of peptide ligands.

    abstract::Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major o...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2011.01.004

    authors: Vanhee P,van der Sloot AM,Verschueren E,Serrano L,Rousseau F,Schymkowitz J

    更新日期:2011-05-01 00:00:00

  • A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering.

    abstract::Musculoskeletal diseases are increasing the prevalence of physical disability worldwide. Within the body, musculoskeletal soft and hard tissues integrate through specific multitissue transitions, allowing for body movements. Owing to their unique compositional and structural gradients, injuries challenge the native in...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2019.06.003

    authors: Calejo I,Costa-Almeida R,Reis RL,Gomes ME

    更新日期:2020-01-01 00:00:00

  • Applications of flow cytometry to ecotoxicity testing using microalgae.

    abstract::Flow cytometry is a rapid method for the quantitative measurement of light scattering and fluorescent properties of cells. Although this technique has been widely applied to biomedical and environmental studies, its potential as a tool in ecotoxicological studies has not yet been fully exploited. This article describe...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/s0167-7799(01)01924-2

    authors: Stauber JL,Franklin NM,Adams MS

    更新日期:2002-04-01 00:00:00

  • Engineering biofilm formation and dispersal.

    abstract::Anywhere water is in the liquid state, bacteria will exist as biofilms, which are complex communities of cells that are cemented together. Although frequently associated with disease and biofouling, biofilms are also important for engineering applications, such as bioremediation, biocatalysis and microbial fuel cells....

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2010.11.001

    authors: Wood TK,Hong SH,Ma Q

    更新日期:2011-02-01 00:00:00

  • Decellularized Extracellular Matrix for Bioengineering Physiomimetic 3D in Vitro Tumor Models.

    abstract::Recent advances in the extraction and purification of decellularized extracellular matrix (dECM) obtained from healthy or malignant tissues open new avenues for engineering physiomimetic 3D in vitro tumor models, which closely recapitulate key biomolecular hallmarks and the dynamic cancer cell-ECM interactions in the ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2020.04.006

    authors: Ferreira LP,Gaspar VM,Mano JF

    更新日期:2020-12-01 00:00:00

  • Colloidal gas aphrons: potential applications in biotechnology

    abstract::Colloidal gas aphrons are microbubbles encapsulated by surfactant multilayers. They provide a large interfacial area to adsorb charged and/or hydrophobic molecules; the extent and mechanism of the adsorption depends on the surfactant multilayer. The physical properties of colloidal gas aphrons have recently been chara...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章

    doi:10.1016/s0167-7799(99)01363-3

    authors: Jauregi P,Varley J

    更新日期:1999-10-01 00:00:00

  • Engineering cyanobacteria to generate high-value products.

    abstract::Although many microorganisms have been used for the bioindustrial generation of valuable metabolites, the productive potential of cyanobacterial species has remained largely unexplored. Cyanobacteria possess several advantages as organisms for bioindustrial processes, including simple input requirements, tolerance of ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2010.12.003

    authors: Ducat DC,Way JC,Silver PA

    更新日期:2011-02-01 00:00:00

  • Non-invasive wearable electrochemical sensors: a review.

    abstract::Wearable sensors have garnered considerable recent interest owing to their tremendous promise for a plethora of applications. Yet the absence of reliable non-invasive chemical sensors has greatly hindered progress in the area of on-body sensing. Electrochemical sensors offer considerable promise as wearable chemical s...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tibtech.2014.04.005

    authors: Bandodkar AJ,Wang J

    更新日期:2014-07-01 00:00:00