Decellularized Extracellular Matrix for Bioengineering Physiomimetic 3D in Vitro Tumor Models.

abstract：:We describe factors promoting the exploration of locally sourced probiotics, targeting local populations to balance human needs and market opportunities. This would be particularly beneficial for people in developing countries, who generally lack access to affordable probiotics and are often exposed to poor hygiene co...

journal_title：Trends in biotechnology

authors： Sybesma W,Kort R,Lee YK

更新日期：2015-04-01 00:00:00

abstract：:Patterned regular sieves and filters with comparable molecular dimensions hold great promise as an alternative to conventional polymeric gels and fibrous membranes to improve biomolecule separation. Recent developments of microfabricated nanofluidic sieves and filters have demonstrated superior performance for both an...

journal_title：Trends in biotechnology

authors： Fu J,Mao P,Han J

更新日期：2008-06-01 00:00:00

abstract：:Marine natural products (NP) are unanimously acknowledged as the 'blue gold' in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolit...

journal_title：Trends in biotechnology

authors： Leal MC,Calado R,Sheridan C,Alimonti A,Osinga R

更新日期：2013-10-01 00:00:00

abstract：:Despite the wealth of research on stem-cell biology and therapy, there have been few advances in the ex vivo expansion of adult stem cells. Fetal bovine serum, which can elicit an immune reaction in hosts receiving cellular products, remains essential to the culture methods. Recent work by Prockop et al. suggests that...

journal_title：Trends in biotechnology

authors： Horwitz EM

更新日期：2004-08-01 00:00:00

abstract：:Proteins found in nature have traditionally been the most frequently used biocatalysts to produce numerous natural products ranging from commodity chemicals to pharmaceuticals. Protein engineering has emerged as a powerful biotechnological toolbox in the development of metabolic engineering, particularly for the biosy...

journal_title：Trends in biotechnology

authors： Li C,Zhang R,Wang J,Wilson LM,Yan Y

更新日期：2020-07-01 00:00:00

abstract：:We discuss the general properties of optical imaging in three-dimensional object domains from an information-theoretic standpoint, expressing system performance in terms of imaging mutual information (IMI). We use IMI to characterize volume holographic imaging, a new optical imaging method with depth discrimination ca...

journal_title：Trends in biotechnology

authors： Barbastathis G,Sinha A

更新日期：2001-10-01 00:00:00

abstract：:This article reports on the state-of-the-art technologies that sequence DNA using miniaturized devices. The article considers the miniaturization of existing technologies for sequencing DNA and the opportunities for cost reduction that 'on-chip' devices can deliver. The ability to construct nano-scale structures and p...

journal_title：Trends in biotechnology

authors： Ryan D,Rahimi M,Lund J,Mehta R,Parviz BA

更新日期：2007-09-01 00:00:00

abstract：:Step by step, the components of an artificial form of cellular life are being assembled by researchers. Lipid vesicles the size of small bacteria can be prepared and under certain conditions are able to grow and divide, then grow again. Polymerase enzymes encapsulated in the vesicles can synthesize RNA from externally...

journal_title：Trends in biotechnology

authors： Deamer D

更新日期：2005-07-01 00:00:00

abstract：:The use of antibodies or antibody fragments for targeting tumors (either for tumor imaging or as carriers for drugs or toxins), has encountered problems of clearance, and non-specific or inefficient binding in clinical trials. A novel approach, linking two antibody variable fragments (Fvs), with a short peptide to gen...

journal_title：Trends in biotechnology

authors： Bird RE,Walker BW

更新日期：1991-04-01 00:00:00

abstract：:Continued progress in cell-phone devices has made them powerful mobile computers, equipped with sophisticated, permanent physical sensors embedded as the default configuration. By contrast, the incorporation of permanent biosensors in cell-phone units has been prevented by the multivocal nature of the stimuli and the ...

journal_title：Trends in biotechnology

authors： Preechaburana P,Suska A,Filippini D

更新日期：2014-07-01 00:00:00

abstract：:Bioremediation differs from other industrial biotechnologies in that, although bioremediation contractors must profit from the activity, the primary driver is regulatory compliance rather than manufacturing profit. It is an attractive technology in the context of a bioeconomy but currently has limitations at the field...

journal_title：Trends in biotechnology

authors： Gillespie IM,Philp JC

更新日期：2013-06-01 00:00:00

abstract：:Pressure is a thermodynamic parameter whose unique effects on biological systems are increasingly being studied in a growing number of scientific fields. As such, the effects of high pressure are currently being investigated at different levels, ranging from proteins, enzymes and viruses to microorganisms, mammalian c...

journal_title：Trends in biotechnology

authors： Aertsen A,Meersman F,Hendrickx ME,Vogel RF,Michiels CW

更新日期：2009-07-01 00:00:00

abstract：:Reconstituted viral envelopes (RVEs) are formed by solubilizing intact virus in detergent and reassembling the envelope on removal of detergent. RVEs can be formed in the presence of agents that become encapsulated and can then be utilized in vitro and in vivo for drug delivery, cell destruction, transfer of membrane ...

journal_title：Trends in biotechnology

authors： Blumenthal R,Loyter A

更新日期：1991-02-01 00:00:00

abstract：:Protein phosphorylation is a complex and highly dynamic process involved in numerous biological events. Abnormal phosphorylation is one of the underlying mechanisms for the development of cancer and metabolic disorders. The identification and absolute quantification of specific phospho-signatures can help elucidate pr...

journal_title：Trends in biotechnology

authors： Batalha IL,Lowe CR,Roque AC

更新日期：2012-02-01 00:00:00

abstract：:Here, we discuss recent advances in the development of artificial red blood cell (RBC) substitutes, illustrating lessons learned from initial attempts using perfluorocarbon (PFC) emulsions and acellular hemoglobin-based oxygen carriers (HBOCs). We also highlight novel oxygen-containing microparticles, nanoparticles, a...

journal_title：Trends in biotechnology

authors： Tao Z,Ghoroghchian PP

更新日期：2014-09-01 00:00:00

abstract：:Techniques such as positron-emission tomography, single-photon-emission computed tomography, functional magnetic-resonance imaging and magnetoencephalography permit the observation of biological processes in the brain in a noninvasive manner. They have yielded new insights into the biological interrelations of sensory...

journal_title：Trends in biotechnology

authors： Müller-Gärtner HW

更新日期：1998-03-01 00:00:00

abstract：:The promising recognition characteristics exhibited by biomolecules have caused significant interest in biomolecule-based sensor strategies. Here we review several emerging biosensor designs that use modulated electron or energy transfer to a bio-specific ligand as the signaling mechanism. The efficiencies of both ele...

journal_title：Trends in biotechnology

authors： Fan C,Plaxco KW,Heeger AJ

更新日期：2005-04-01 00:00:00

abstract：:Despite the recognized potential of viral vectors for gene therapy, growing biological concerns are prompting the exploration of safer, non-viral vectors to deliver therapeutic nucleic acids. In this context, recombinant proteins can be bioproduced on a large scale, without the need for further in vitro modifications,...

journal_title：Trends in biotechnology

authors： Arís A,Villaverde A

更新日期：2004-07-01 00:00:00

abstract：:Opinions on what synthetic biology actually is range from a natural extension of genetic engineering to a new manufacturing paradigm. It offers, for the first time in the life sciences, rational design and engineering standardisation. It could address problems across a broad spectrum of human concerns, including energ...

journal_title：Trends in biotechnology

authors： Philp JC,Ritchie RJ,Allan JE

更新日期：2013-05-01 00:00:00

abstract：:Nanotechnology is currently driving the dental materials industry to substantial growth, thus reflecting on improvements in materials available for oral prevention and treatment. The present review discusses new developments in nanotechnology applied to dentistry, focusing on the use of nanomaterials for improving the...

journal_title：Trends in biotechnology

authors： Padovani GC,Feitosa VP,Sauro S,Tay FR,Durán G,Paula AJ,Durán N

更新日期：2015-11-01 00:00:00

abstract：:Targeting apoptotic cell death pathways provides wide-ranging opportunities for the discovery and development of novel drugs. Some targeted therapies that selectively induce apoptosis in cancer cells are already marketed, and numerous pro-apoptotic drugs for treating cancer are currently being developed. The anti-apop...

journal_title：Trends in biotechnology

authors： Alam JJ

更新日期：2003-11-01 00:00:00

abstract：:The discovery of targets that are sufficiently robust to yield marketable therapeutics is an enormous challenge. Through the years, several approaches have been used with varying degrees of success. These include target-independent screening of tumor-derived cell lines (disease-dependent), reductionist approaches to i...

journal_title：Trends in biotechnology

authors： Ryan TE,Patterson SD

更新日期：2002-12-01 00:00:00

abstract：:The concept of ecological 'traps' is based in theory from ecology and conservation biology that has now found application to infectious diseases with a study from Paul Turner's group. This study is important because it offers a mathematical model of ecological traps, applies this model to viruses, and tests the model ...

journal_title：Trends in biotechnology

authors： Long CD,Turner-Shelef K,Relman DA

更新日期：2007-12-01 00:00:00

abstract：:The baculovirus expression system has been used extensively for the expression of recombinant proteins in insect cells. Recently, recombinant baculovirus vectors engineered to contain mammalian cell-active promoter elements, have been used successfully for transient and stable gene delivery in a broad spectrum of prim...

journal_title：Trends in biotechnology

authors： Kost TA,Condreay JP

更新日期：2002-04-01 00:00:00

abstract：:Phytoremediation holds promise for in situ treatment of heavy metal contaminated soils. Recently, the benefits of combining siderophore-producing bacteria (SPB) with plants for metal removal from contaminated soils have been demonstrated. Metal-resistant SPB play an important role in the successful survival and growth...

journal_title：Trends in biotechnology

authors： Rajkumar M,Ae N,Prasad MN,Freitas H

更新日期：2010-03-01 00:00:00

abstract：:In vitro antibody generation technologies have now been available for two decades. Research reagents prepared via phage display are becoming available and several recent studies have demonstrated that these technologies are now sufficiently advanced to facilitate generation of a comprehensive renewable resource of ant...

journal_title：Trends in biotechnology

authors： Dübel S,Stoevesandt O,Taussig MJ,Hust M

更新日期：2010-07-01 00:00:00

abstract：:The process of studying dynamic three-dimensional samples has a long history in biological research. Recent advances in hardware and software have made it easier to visualise and record interior detail from multiple focal planes of three-dimensional samples as they change over time (four-dimensional imaging). Once cap...

journal_title：Trends in biotechnology

authors： Thomas CF,White JG

更新日期：1998-04-01 00:00:00

abstract：:Intravital imaging enables to study dynamic tumour-stroma interactions within primary and metastatic sites, including the lung. The combination of optical windows with specific molecular probes targeting the tumour microenvironment will provide new insights into prometastatic stromal interactions and lead to novel the...

journal_title：Trends in biotechnology

authors： Kitamura T,Pollard JW,Vendrell M

更新日期：2017-01-01 00:00:00

abstract：:Advances in high-throughput DNA-sequencing techniques have given us the unprecedented ability to rapidly determine the nucleotide sequences of entire bacterial genomes. The application of these methods to the genomes of microbial pathogens, combined with efficient analytical tools and genome-scale approaches for study...

journal_title：Trends in biotechnology

authors： Smith DR

更新日期：1996-08-01 00:00:00

abstract：:The demands on drug discovery organizations have increased dramatically in recent years, partly because of the need to identify novel targets that are both relevant to disease and chemically tractable. This is leading to an industrial approach to traditional biology and chemistry, inspired in part by the revolution in...

journal_title：Trends in biotechnology

authors： Dean PM,Zanders ED,Bailey DS

更新日期：2001-08-01 00:00:00