Unique peptide modifications involved in the biosynthesis of lantibiotics.

abstract：:The expression 'crystal clear' stems from the science of crystallography, which determines the detailed atomic structures of materials by exposing crystals to X-rays. Protein structures are pivotal to the success of rational drug design and other biotechnology applications; however, obtaining high quality crystals pos...

journal_title：Trends in biotechnology

authors： Saridakis E,Chayen NE

更新日期：2009-02-01 00:00:00

abstract：:Low production cost is a key factor driving the development of plants and plant tissue cultures for the synthesis of therapeutic and other foreign proteins. Because product yield and concentration exert a major influence on process economics, improving foreign protein accumulation is crucial for enhancing the commerci...

journal_title：Trends in biotechnology

authors： Doran PM

更新日期：2006-09-01 00:00:00

abstract：:Traditionally, biotechnology design has focused on the manufacture of chemicals and biologics. Still, a majority of biotechnology products that appear on the market today is the result of mechanical-electric (mechatronic) construction. For these, the biological components play decisive roles in the design solution; th...

journal_title：Trends in biotechnology

authors： Mandenius CF,Björkman M

更新日期：2010-05-01 00:00:00

abstract：:Psychrophilic anaerobic treatment is an attractive option for wastewaters that are discharged at moderate to low temperature. The expanded granular sludge bed (EGSB) reactor has been shown to be a feasible system for anaerobic treatment of mainly soluble and pre-acidified wastewater at temperatures of 5--10 degrees C....

journal_title：Trends in biotechnology

authors： Lettinga G,Rebac S,Zeeman G

更新日期：2001-09-01 00:00:00

abstract：:Innovative fermentation processes are necessary for the cost-effective production of bulk chemicals from renewable resources. Current microbial processes are either anaerobic processes, with high yield and productivity, or less-efficient aerobic processes. Oxygen utilization plays an important role in energy generatio...

journal_title：Trends in biotechnology

authors： Weusthuis RA,Lamot I,van der Oost J,Sanders JP

更新日期：2011-04-01 00:00:00

abstract：:Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recen...

journal_title：Trends in biotechnology

authors： Cormode DP,Gao L,Koo H

更新日期：2018-01-01 00:00:00

abstract：:Since its invention at the beginning of the 1990s, antibody phage display has revolutionized the generation of monoclonal antibodies and their engineering. It is now possible to create antibodies binding to any chosen target antigen without the use of laboratory animals or hybridomas, in a system that completely by-pa...

journal_title：Trends in biotechnology

authors： Hoogenboom HR

更新日期：1997-02-01 00:00:00

abstract：:Intravital imaging enables to study dynamic tumour-stroma interactions within primary and metastatic sites, including the lung. The combination of optical windows with specific molecular probes targeting the tumour microenvironment will provide new insights into prometastatic stromal interactions and lead to novel the...

journal_title：Trends in biotechnology

authors： Kitamura T,Pollard JW,Vendrell M

更新日期：2017-01-01 00:00:00

abstract：:In the future, biomass will continue to emerge as a viable source of chemicals. The development of new industries that utilize bio-renewables provides opportunities for innovation. For example, bio- and chemo-catalysts can be combined in 'one pot' to prepare chemicals of commercial value. This has been demonstrated us...

journal_title：Trends in biotechnology

authors： Marr AC,Liu S

更新日期：2011-05-01 00:00:00

abstract：:Porous microcarriers are new support materials with important advantages in both industrial cell-culture processes and the culture of cells of medical importance. Porous microcarriers are now commercially available with internal architecture and surface chemistry suitable for culture of both anchorage-dependent and an...

journal_title：Trends in biotechnology

authors： Cahn F

更新日期：1990-05-01 00:00:00

abstract：:Molecularly imprinted polymers (MIPs) are prepared by creating a three-dimensional polymeric matrix around a template molecule. After the matrix is removed, complementary cavities with respect to shape and functional groups remain. MIPs have been produced for applications in in vitro diagnostics, therapeutics and sepa...

journal_title：Trends in biotechnology

authors： Poma A,Turner AP,Piletsky SA

更新日期：2010-12-01 00:00:00

abstract：:Metabolomics embraces several strategies that aim to quantify cell metabolites in order to increase our understanding of how metabolite levels and interactions influence phenotypes. Metabolic footprinting represents a niche within metabolomics, because it focuses on the analysis of extracellular metabolites. Although ...

journal_title：Trends in biotechnology

authors： Mapelli V,Olsson L,Nielsen J

更新日期：2008-09-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease resulting from the destruction of pancreatic insulin-producing beta cells that most frequently occurs in genetically predisposed children. Recent observations illustrating the regenerative capability of the endocrine pancreas in addition to advances in stem cell and gene ...

journal_title：Trends in biotechnology

authors： Pasquali L,Fan Y,Trucco M,Ringquist S

更新日期：2006-11-01 00:00:00

abstract：:The tricarboxylic acid (TCA) cycle has been used for decades in the microbial production of chemicals such as citrate, L-glutamate, and succinate. Maximizing yield is key for cost-competitive production. However, for most TCA cycle products, the maximum pathway yield is lower than the theoretical maximum yield (Y(E))....

journal_title：Trends in biotechnology

authors： Vuoristo KS,Mars AE,Sanders JPM,Eggink G,Weusthuis RA

更新日期：2016-03-01 00:00:00

abstract：:Platelet-derived products (PDPs) have gained popularity, mainly due to their high concentrations of bioactive molecules such as growth factors and cytokines, which play important roles in tissue healing and regeneration. PDPs are obtained through minimally invasive procedures and their therapeutic effect has been wide...

journal_title：Trends in biotechnology

authors： Soares CS,Babo PS,Reis RL,Carvalho PP,Gomes ME

更新日期：2020-08-28 00:00:00

abstract：:Benzylisoquinoline alkaloids (BIAs) are a family of ∼2500 alkaloids with both potential and realized pharmaceutical value, including most notably the opiates such as codeine and morphine. Only a few BIAs accumulate readily in plants, which limits the pharmaceutical potential of the family. Shifting BIA production to m...

journal_title：Trends in biotechnology

authors： Narcross L,Fossati E,Bourgeois L,Dueber JE,Martin VJJ

更新日期：2016-03-01 00:00:00

abstract：:Genomic research is expected to generate new types of complex observational data, changing the types of experiments as well as our understanding of biological processes. The investigation and definition of relationships among proteins is essential for understanding the function of each gene and the mechanisms of biolo...

journal_title：Trends in biotechnology

authors： Haberkorn U,Altmann A

更新日期：2003-06-01 00:00:00

abstract：:Along with the development of metabolic engineering and synthetic biology tools, various microbes are being used to produce aromatic chemicals. In microbes, aromatics are mainly produced via a common important precursor, chorismate, in the shikimate pathway. Natural or non-natural aromatics have been produced by engin...

journal_title：Trends in biotechnology

authors： Noda S,Kondo A

更新日期：2017-08-01 00:00:00

abstract：:Vascularisation is key to developing large transplantable tissue constructs capable of providing therapeutic benefits. The vascularised tissue engineering chamber originates from surgical concepts in tissue prefabrication and microsurgery. It serves as an in vivo bioreactor in the form of a closed, protected space sur...

journal_title：Trends in biotechnology

authors： Yap KK,Yeoh GC,Morrison WA,Mitchell GM

更新日期：2018-10-01 00:00:00

abstract：:The process of studying dynamic three-dimensional samples has a long history in biological research. Recent advances in hardware and software have made it easier to visualise and record interior detail from multiple focal planes of three-dimensional samples as they change over time (four-dimensional imaging). Once cap...

journal_title：Trends in biotechnology

authors： Thomas CF,White JG

更新日期：1998-04-01 00:00:00

abstract：:Precise control of transgene expression is pivotal to the engineering of plants with increased disease resistance. Many early attempts to boost disease resistance used constitutive overexpression of defence components but frequently this resulted in poor quality plants. It is now clear that the extensive cellular repr...

journal_title：Trends in biotechnology

authors： Gurr SJ,Rushton PJ

更新日期：2005-06-01 00:00:00

abstract：:A switch from a petroleum-based to a biobased economy requires the capacity to produce both high-value low-volume and low-value high-volume products. Recent evidence supports the development of microalgae-based microbial cell factories with the objective of establishing environmentally sustainable manufacturing soluti...

journal_title：Trends in biotechnology

authors： Butler T,Kapoore RV,Vaidyanathan S

更新日期：2020-06-01 00:00:00

abstract：:Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome ...

journal_title：Trends in biotechnology

authors： Kanchiswamy CN,Malnoy M,Velasco R,Kim JS,Viola R

更新日期：2015-09-01 00:00:00

abstract：:Technology is a social practice that embodies the capacity of societies to transform themselves by creating and manipulating not only physical objects, but also symbols and cultural forms. It is an illusion that scientific and socioeconomic drivers are the sole elements determining the destiny of a technology. Althoug...

journal_title：Trends in biotechnology

authors： Mordini E

更新日期：2007-12-01 00:00:00

abstract：:Colloidal gas aphrons are microbubbles encapsulated by surfactant multilayers. They provide a large interfacial area to adsorb charged and/or hydrophobic molecules; the extent and mechanism of the adsorption depends on the surfactant multilayer. The physical properties of colloidal gas aphrons have recently been chara...

journal_title：Trends in biotechnology

authors： Jauregi P,Varley J

更新日期：1999-10-01 00:00:00

abstract：:Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues. Many synthetic or natural biomaterials have been developed for this purpose and are used to deliver wound therapeutics in a controlled manner that prevents unwan...

journal_title：Trends in biotechnology

authors： Andreadis ST,Geer DJ

更新日期：2006-07-01 00:00:00

abstract：:Mutasynthesis couples the power of chemical synthesis with molecular biology to generate derivatives of medicinally valuable, natural products. Recently, this technique has been exploited by Cambridge-based biotech company Biotica Technology Ltd, and their collaborators, to generate promising new variants of the polyk...

journal_title：Trends in biotechnology

authors： Weissman KJ

更新日期：2007-04-01 00:00:00

abstract：:In Europe the commercialization of food derived from genetically modified plants has been slow because of the complex regulatory process and the concerns of consumers. Risk assessment is focused on potential adverse effects on humans and the environment, which could result from unintended effects of genetic modificati...

journal_title：Trends in biotechnology

authors： Rischer H,Oksman-Caldentey KM

更新日期：2006-03-01 00:00:00

abstract：:Atherosclerosis and heart disease are still the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts but the patency of such grafts is limited compared to natural materials. Tissue engineering, whereby living tissue replacements can be co...

journal_title：Trends in biotechnology

authors： Sales KM,Salacinski HJ,Alobaid N,Mikhail M,Balakrishnan V,Seifalian AM

更新日期：2005-09-01 00:00:00

abstract：:The baculovirus expression system has been used extensively for the expression of recombinant proteins in insect cells. Recently, recombinant baculovirus vectors engineered to contain mammalian cell-active promoter elements, have been used successfully for transient and stable gene delivery in a broad spectrum of prim...

journal_title：Trends in biotechnology

authors： Kost TA,Condreay JP

更新日期：2002-04-01 00:00:00