Combining bio- and chemo-catalysis: from enzymes to cells, from petroleum to biomass.

abstract：:Antibodies are able to both bind antigens and trigger the responses that eliminate them from circulation. All antibodies are glycosylated at conserved positions in their constant regions, and the presence of carbohydrate can be critical for antigen clearance functions such as complement activation. The structure of th...

journal_title：Trends in biotechnology

authors： Wright A,Morrison SL

更新日期：1997-01-01 00:00:00

abstract：:Brain-machine interfaces (BMIs) enable humans to interact with devices by modulating their brain signals. Despite impressive technological advancements, several obstacles remain. The most commonly used BMI control signals are derived from the brain areas involved in primary sensory- or motor-related processing. Howeve...

journal_title：Trends in biotechnology

authors： Min BK,Chavarriaga R,Millán JDR

更新日期：2017-07-01 00:00:00

abstract：:Microbes are present at every crime scene and have been used as physical evidence for over a century. Advances in DNA sequencing and computational approaches have led to recent breakthroughs in the use of microbiome approaches for forensic science, particularly in the areas of estimating postmortem intervals (PMIs), l...

journal_title：Trends in biotechnology

authors： Metcalf JL,Xu ZZ,Bouslimani A,Dorrestein P,Carter DO,Knight R

更新日期：2017-09-01 00:00:00

abstract：:Room temperature ionic liquids are non-volatile, thermally stable and highly polar; they are also moderately hydrophilic solvents. Here, we discuss their use as reaction media for biocatalysis. Enzymes of widely diverging types are catalytically active in ionic liquids or aqueous biphasic ionic liquid systems. Lipases...

journal_title：Trends in biotechnology

authors： van Rantwijk F,Madeira Lau R,Sheldon RA

更新日期：2003-03-01 00:00:00

abstract：:Nanosilver (NS), comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that NS has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings ...

journal_title：Trends in biotechnology

authors： Chaloupka K,Malam Y,Seifalian AM

更新日期：2010-11-01 00:00:00

abstract：:Although there is still some skepticism in the biological community regarding the value and significance of quantitative computational modeling, important steps are continually being taken to enhance its accessibility and predictive power. We view these developments as essential components of an emerging 'respectful m...

journal_title：Trends in biotechnology

authors： Tsigkinopoulou A,Baker SM,Breitling R

更新日期：2017-06-01 00:00:00

abstract：:The ability to detect single-base changes is of fundamental importance in molecular genetics. This is particularly true in human genetics, where interest in linking mutations of identified genes to particular disease phenotypes is most intense, and where a demand exists for clinical diagnosis of defined mutations. In ...

journal_title：Trends in biotechnology

authors： Prosser J

更新日期：1993-06-01 00:00:00

abstract：:Mutasynthesis couples the power of chemical synthesis with molecular biology to generate derivatives of medicinally valuable, natural products. Recently, this technique has been exploited by Cambridge-based biotech company Biotica Technology Ltd, and their collaborators, to generate promising new variants of the polyk...

journal_title：Trends in biotechnology

authors： Weissman KJ

更新日期：2007-04-01 00:00:00

abstract：:Geological storage of CO2 is a fast-developing technology that can mitigate rising carbon emissions. However, there are environmental concerns with the long-term storage and implications of a leak from a carbon capture storage (CCS) site. Traditional monitoring lacks clear protocols and relies heavily on physical meth...

journal_title：Trends in biotechnology

authors： Hicks N,Vik U,Taylor P,Ladoukakis E,Park J,Kolisis F,Jakobsen KS

更新日期：2017-01-01 00:00:00

abstract：:Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, such as antibody targeting. The pH (low) insertion peptides (pHLIP®s) provide new opportunities for targeting acidic tissues. Through the physical mechanism of membran...

journal_title：Trends in biotechnology

authors： Wyatt LC,Lewis JS,Andreev OA,Reshetnyak YK,Engelman DM

更新日期：2017-07-01 00:00:00

abstract：:Bioelectrochemical power-to-gas (BEP2G) is considered a potentially convenient way of storing renewable surplus electricity in the form of methane. In methane-producing bioelectrochemical systems (BESs), carbon dioxide and electrical energy are converted into methane, using electrodes that supply either electrons or h...

journal_title：Trends in biotechnology

authors： Geppert F,Liu D,van Eerten-Jansen M,Weidner E,Buisman C,Ter Heijne A

更新日期：2016-11-01 00:00:00

abstract：:A key aspect of the genomics revolution is the transformation of large amounts of biological information into an electronic format, leading to an information-based approach to biomedical problems. Large-scale RNA assays and gene-expression-microarray studies, in particular, represent the second wave of the genomics re...

journal_title：Trends in biotechnology

authors： Zweiger G

更新日期：1999-11-01 00:00:00

abstract：:The endothelium lining blood vessels expresses molecules that are restricted in their expression to a particular tissue or organ. These molecules are attractive targets for therapy and diagnosis because they allow agents to be delivered specifically to the blood vessels supplying the desired tissue. However, it is dif...

journal_title：Trends in biotechnology

authors： George AJ,Lee L,Pitzalis C

更新日期：2003-05-01 00:00:00

abstract：:Atmospheric pressure gas plasmas are emerging as a promising treatment in cancer that can supplement the existing set of treatment modalities and, when combined with other therapies, enhance their selectivity and efficacy against resistant cancers. With further optimisation in production and administration of plasma t...

journal_title：Trends in biotechnology

authors： Dai X,Bazaka K,Richard DJ,Thompson ERW,Ostrikov KK

更新日期：2018-11-01 00:00:00

abstract：:Stem cell differentiation is regulated by the complex interplay of multiple parameters, including adhesive intercellular interactions, cytoskeletal and extracellular matrix remodeling, and gradients of agonists and antagonists that individually and collectively vary as a function of spatial locale and temporal stages ...

journal_title：Trends in biotechnology

authors： Kinney MA,McDevitt TC

更新日期：2013-02-01 00:00:00

abstract：:Discussions on research quality and reproducibility are appearing in the pages of scientific journals with heightened significance and gaining media attention. Many institutions have developed guidelines to address the topic of quality in basic research, but questions remain about how best to implement and monitor com...

journal_title：Trends in biotechnology

authors： Riedl DH,Dunn MK

更新日期：2013-10-01 00:00:00

abstract：:Microbial contamination of polymer surfaces has become a significant challenge in domestic, industrial, and biomedical applications. Recent progress in our understanding of how topographical features of different length scales can be used to effectively and selectively control the attachment and proliferation of diffe...

journal_title：Trends in biotechnology

authors： Nguyen DHK,Bazaka O,Bazaka K,Crawford RJ,Ivanova EP

更新日期：2020-05-01 00:00:00

abstract：:In recent years, entrapment of cells within spheres of Ca2+ alginate has become the most widely used technique for immobilizing living cells. This versatile method includes applications ranging from immobilization of living or dead cells in bioreactors, immobilization of plant protoplasts for micropropagation and immo...

journal_title：Trends in biotechnology

authors： Smidsrød O,Skjåk-Braek G

更新日期：1990-03-01 00:00:00

abstract：:Techniques such as positron-emission tomography, single-photon-emission computed tomography, functional magnetic-resonance imaging and magnetoencephalography permit the observation of biological processes in the brain in a noninvasive manner. They have yielded new insights into the biological interrelations of sensory...

journal_title：Trends in biotechnology

authors： Müller-Gärtner HW

更新日期：1998-03-01 00:00:00

abstract：:Despite the recognized potential of viral vectors for gene therapy, growing biological concerns are prompting the exploration of safer, non-viral vectors to deliver therapeutic nucleic acids. In this context, recombinant proteins can be bioproduced on a large scale, without the need for further in vitro modifications,...

journal_title：Trends in biotechnology

authors： Arís A,Villaverde A

更新日期：2004-07-01 00:00:00

abstract：:This article reports on the state-of-the-art technologies that sequence DNA using miniaturized devices. The article considers the miniaturization of existing technologies for sequencing DNA and the opportunities for cost reduction that 'on-chip' devices can deliver. The ability to construct nano-scale structures and p...

journal_title：Trends in biotechnology

authors： Ryan D,Rahimi M,Lund J,Mehta R,Parviz BA

更新日期：2007-09-01 00:00:00

abstract：:Many pathogens have the ability to vary the antigenic composition of surface-associated antigens. Often, this variation is mediated by the regulation of gene expression. By varying its antigenicity, the pathogen is able to avoid host immune responses more efficiently; however, this makes the design of vaccines against...

journal_title：Trends in biotechnology

authors： Maskell D,Frankel G,Dougan G

更新日期：1993-12-01 00:00:00

abstract：:The expression 'crystal clear' stems from the science of crystallography, which determines the detailed atomic structures of materials by exposing crystals to X-rays. Protein structures are pivotal to the success of rational drug design and other biotechnology applications; however, obtaining high quality crystals pos...

journal_title：Trends in biotechnology

authors： Saridakis E,Chayen NE

更新日期：2009-02-01 00:00:00

abstract：:Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recen...

journal_title：Trends in biotechnology

authors： Cormode DP,Gao L,Koo H

更新日期：2018-01-01 00:00:00

abstract：:The current productivity crisis in drug discovery has prompted the pharmaceutical industry to decentralize R&D, which is now more responsive, more flexible and better connected to research in academia and biotechnology firms. Organizational changes are also under way in academia. Universities are expanding their techn...

journal_title：Trends in biotechnology

authors： West W,Nightingale P

更新日期：2009-10-01 00:00:00

abstract：:High-throughput genetic screens interfering with gene expression are invaluable tools to identify gene function and phenotype-to-genotype interactions. Implementing such screens in the laboratory is challenging, and the choice between currently available technologies based on RNAi and CRISPR/Cas9 (CRISPR-associated pr...

journal_title：Trends in biotechnology

authors： Schuster A,Erasimus H,Fritah S,Nazarov PV,van Dyck E,Niclou SP,Golebiewska A

更新日期：2019-01-01 00:00:00

abstract：:Since its inception a decade ago, sol-gel encapsulation has opened up an intriguing new way to immobilize biological materials. An array of substances, including catalytic antibodies, DNA, RNA, antigens, live bacterial, fungal, plant and animal cells and whole protozoa, have been encapsulated in silica, metal-oxide, o...

journal_title：Trends in biotechnology

authors： Gill I,Ballesteros A

更新日期：2000-07-01 00:00:00

abstract：:Life science in the 21st century is developing rapidly through the structural analysis of biomolecules, the completion of the human genome sequence and the analysis of transcriptomes. The mouse transcriptome has been comprehensively analyzed using a gene discovery approach to collect full-length cDNA (FL-cDNA) clones....

journal_title：Trends in biotechnology

authors： Hayashizaki Y,Kanamori M

更新日期：2004-04-01 00:00:00

abstract：:Despite the wealth of research on stem-cell biology and therapy, there have been few advances in the ex vivo expansion of adult stem cells. Fetal bovine serum, which can elicit an immune reaction in hosts receiving cellular products, remains essential to the culture methods. Recent work by Prockop et al. suggests that...

journal_title：Trends in biotechnology

authors： Horwitz EM

更新日期：2004-08-01 00:00:00

abstract：:The prevalence of antimicrobial-resistant pathogens has highlighted the urgent need for new drugs. Actinomycetes have been the most prominent sources of natural products for drug discovery and development. Advances in genomics have inspired several emerging strategies to reinvigorate the field of natural product disco...

journal_title：Trends in biotechnology

authors： Niu G

更新日期：2018-03-01 00:00:00