Combining bio- and chemo-catalysis: from enzymes to cells, from petroleum to biomass.


:In the future, biomass will continue to emerge as a viable source of chemicals. The development of new industries that utilize bio-renewables provides opportunities for innovation. For example, bio- and chemo-catalysts can be combined in 'one pot' to prepare chemicals of commercial value. This has been demonstrated using isolated enzymes and whole cells for a variety of chemical transformations. The one-pot approach has been successfully adopted to convert chemicals derived from biomass, and, in our opinion, it has an important role to play in the design of a more sustainable chemical industry. To implement new one-pot bio- and chemo-catalytic processes, issues of incompatibility must be overcome; the strategies for which are discussed in this opinion article.


Trends Biotechnol


Trends in biotechnology


Marr AC,Liu S




Has Abstract


2011-05-01 00:00:00














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    authors: Dai X,Bazaka K,Richard DJ,Thompson ERW,Ostrikov KK

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  • From genes to protein structure and function: novel applications of computational approaches in the genomic era.

    abstract::The genome-sequencing projects are providing a detailed 'parts list' of life. A key to comprehending this list is understanding the function of each gene and each protein at various levels. Sequence-based methods for function prediction are inadequate because of the multifunctional nature of proteins. However, just kn...

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    authors: Skolnick J,Fetrow JS

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  • Confessions of a bioenergy advocate.

    abstract::Feedstocks that deserve serious consideration for fuels and chemicals are sugarcane, corn, trees and algae. Commercialization of biomass refining is imminent but the wild claims of those who think that bioenergy can replace much of our dependence on foreign oil are appalling. It is naive to view biomass as the panacea...

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    authors: Bungay HR

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  • Searching for process information in the aroma of cell cultures.

    abstract::Aroma emissions from living cells can provide valuable information about the metabolic and physiological condition of those cells. Electronic noses are chemical gas-sensor arrays that use artificial neural network models to evaluate aromas. They can interpret the complex aroma information emitted from cultures of bact...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Bachinger T,Mandenius CF

    更新日期:2000-12-01 00:00:00

  • Bioremediation, an environmental remediation technology for the bioeconomy.

    abstract::Bioremediation differs from other industrial biotechnologies in that, although bioremediation contractors must profit from the activity, the primary driver is regulatory compliance rather than manufacturing profit. It is an attractive technology in the context of a bioeconomy but currently has limitations at the field...

    journal_title:Trends in biotechnology

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    authors: Gillespie IM,Philp JC

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  • Artificial molecular sieves and filters: a new paradigm for biomolecule separation.

    abstract::Patterned regular sieves and filters with comparable molecular dimensions hold great promise as an alternative to conventional polymeric gels and fibrous membranes to improve biomolecule separation. Recent developments of microfabricated nanofluidic sieves and filters have demonstrated superior performance for both an...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Fu J,Mao P,Han J

    更新日期:2008-06-01 00:00:00

  • Toward nanoscale genome sequencing.

    abstract::This article reports on the state-of-the-art technologies that sequence DNA using miniaturized devices. The article considers the miniaturization of existing technologies for sequencing DNA and the opportunities for cost reduction that 'on-chip' devices can deliver. The ability to construct nano-scale structures and p...

    journal_title:Trends in biotechnology

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    authors: Ryan D,Rahimi M,Lund J,Mehta R,Parviz BA

    更新日期:2007-09-01 00:00:00

  • Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks.

    abstract::Engineered tissues need a vascular network to supply cells with nutrients and oxygen after implantation. A network that can connect to the vasculature of the patient after implantation can be included during in vitro culture. For optimal integration, this network needs to be highly organized, including venules, capill...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Rouwkema J,Khademhosseini A

    更新日期:2016-09-01 00:00:00

  • Generating recombinant antibodies to the complete human proteome.

    abstract::In vitro antibody generation technologies have now been available for two decades. Research reagents prepared via phage display are becoming available and several recent studies have demonstrated that these technologies are now sufficiently advanced to facilitate generation of a comprehensive renewable resource of ant...

    journal_title:Trends in biotechnology

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    authors: Dübel S,Stoevesandt O,Taussig MJ,Hust M

    更新日期:2010-07-01 00:00:00

  • Drugs against superbugs: private lessons from bacteriophages.

    abstract::Bacterial genomics has provided a plethora of potential targets for antibacterial drug discovery, however, success in the hunt for new antibiotics will hinge on selecting targets with the highest potential. A recent paper by Liu and coworkers describes a new approach to target selection that uncovers strategies used b...

    journal_title:Trends in biotechnology

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    authors: Brown ED

    更新日期:2004-09-01 00:00:00

  • Developments in quantitative mass spectrometry for the analysis of proteome dynamics.

    abstract::Two of the primary responses in a cell when perturbed are modulation of the dynamics of its constituent gene expression and protein abundance to restore steady-state homeostasis. To obtain a detailed model of the restoration of this balance, it is necessary to examine the kinetics of transcription and translation, thu...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Hughes C,Krijgsveld J

    更新日期:2012-12-01 00:00:00

  • Taking your breath away: metabolomics breathes life in to personalized medicine.

    abstract::Breath-based metabolomics (breathomics) is an exciting developing area of biotechnology that centers on the capture, identification, and quantification of volatile organic compound (VOC) patterns in human breath and their utilization as tools in the diagnosis of a broad spectrum of medical problems. With the age of pe...

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    pub_type: 杂志文章,评审


    authors: Rattray NJ,Hamrang Z,Trivedi DK,Goodacre R,Fowler SJ

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  • Synthetic biology, the bioeconomy, and a societal quandary.

    abstract::Opinions on what synthetic biology actually is range from a natural extension of genetic engineering to a new manufacturing paradigm. It offers, for the first time in the life sciences, rational design and engineering standardisation. It could address problems across a broad spectrum of human concerns, including energ...

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    authors: Philp JC,Ritchie RJ,Allan JE

    更新日期:2013-05-01 00:00:00

  • Graphene and graphene oxide: biofunctionalization and applications in biotechnology.

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    authors: Wang Y,Li Z,Wang J,Li J,Lin Y

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  • Neuroimaging-based approaches in the brain-computer interface.

    abstract::Techniques to enable direct communication between the brain and computers/machines, such as the brain-computer interface (BCI) or the brain-machine interface (BMI), are gaining momentum in the neuroscientific realm, with potential applications ranging from medicine to general consumer electronics. Noninvasive BCI tech...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Min BK,Marzelli MJ,Yoo SS

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  • Green biotechnology and European competitiveness.

    abstract::Europe has led many aspects of gene research and yet it has been unable to translate these discoveries into a globally dominant industrial sector. There are valid societal, political and financial reasons for its reluctance to deploy agricultural biotechnology but this reluctance might have unintended consequences. It...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Enriquez J

    更新日期:2001-04-01 00:00:00

  • Facts and fiction of genetically engineered food.

    abstract::The generation of genetically engineered (GE) foods has been raising several concerns and controversies that divide not only the general public but also the scientific community. The fear and importance of the new technology, as well as commercial interests, have supported many of the ongoing discussions. The recent i...

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    pub_type: 杂志文章,评审


    authors: Batista R,Oliveira MM

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  • Advances in the manufacture of MIP nanoparticles.

    abstract::Molecularly imprinted polymers (MIPs) are prepared by creating a three-dimensional polymeric matrix around a template molecule. After the matrix is removed, complementary cavities with respect to shape and functional groups remain. MIPs have been produced for applications in in vitro diagnostics, therapeutics and sepa...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Poma A,Turner AP,Piletsky SA

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  • Single chain antibody variable regions.

    abstract::The use of antibodies or antibody fragments for targeting tumors (either for tumor imaging or as carriers for drugs or toxins), has encountered problems of clearance, and non-specific or inefficient binding in clinical trials. A novel approach, linking two antibody variable fragments (Fvs), with a short peptide to gen...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Bird RE,Walker BW

    更新日期:1991-04-01 00:00:00

  • Microdroplet-Assisted Screening of Biomolecule Production for Metabolic Engineering Applications.

    abstract::Success in synthetic biology and metabolic engineering is quickly becoming 'test' limited within the design-build-test cycle. Commonly used methods for high-throughput screening, including fluorescence-activated cell sorting (FACS) and microtiter plates, have intracellular product and throughput limitations. A growing...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Bowman EK,Alper HS

    更新日期:2020-07-01 00:00:00

  • Two-phase partitioning bioreactors: a new technology platform for destroying xenobiotics.

    abstract::Toxic organic compounds (xenobiotics) pose serious environmental and health risks worldwide. Biological treatment of these materials is severely constrained by their toxic and inhibitory nature and great care is required with respect to the rate at which they are provided to cells. The use of a second, distinct, organ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Daugulis AJ

    更新日期:2001-11-01 00:00:00

  • Extracellular matrix scaffolds for cartilage and bone regeneration.

    abstract::Regenerative medicine approaches based on decellularized extracellular matrix (ECM) scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and regeneration. Moreover, appropriately prepared ECM is biodegrada...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Benders KE,van Weeren PR,Badylak SF,Saris DB,Dhert WJ,Malda J

    更新日期:2013-03-01 00:00:00

  • Commercialization of microfluidic devices.

    abstract::Microfluidic devices offer automation and high-throughput screening, and operate at low volumes of consumables. Although microfluidics has the potential to reduce turnaround times and costs for analytical devices, particularly in medical, veterinary, and environmental sciences, this enabling technology has had limited...

    journal_title:Trends in biotechnology

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    authors: Volpatti LR,Yetisen AK

    更新日期:2014-07-01 00:00:00

  • Antibody separation by hydrophobic charge induction chromatography.

    abstract::Hydrophobic charge induction chromatography using 4-mercapto-ethyl-pyridine as the ligand is an effective method for the separation of antibodies from a variety of feedstocks. Antibodies are adsorbed in physiological conditions without preliminary concentration. Desorption occurs when the pH is lowered, thus inducing ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Boschetti E

    更新日期:2002-08-01 00:00:00

  • Targeted gene therapy: frontiers in the development of 'smart drugs'.

    abstract::Chronic diseases, particularly malignancies and immune-mediated inflammatory diseases (IMIDs), are a challenging frontier for clinical diagnosis and treatment, as well as for biomedical research. Current treatment regimens are frequently insufficient and thus new treatment strategies are needed. Novel therapies for di...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Tarner IH,Müller-Ladner U,Fathman CG

    更新日期:2004-06-01 00:00:00

  • Unique peptide modifications involved in the biosynthesis of lantibiotics.

    abstract::The lantibiotics are a unique class of bacterium-derived peptide antibiotics, all of which contain the rare amino acid lanthionine, as well as a number of other nonprotein amino acids. Unlike most other peptide antibiotics, lantibiotics are produced on the ribosome as a prepeptide, and a series of post-translational m...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Jack RW,Sahl HG

    更新日期:1995-07-01 00:00:00

  • Unintended effects in genetically modified crops: revealed by metabolomics?

    abstract::In Europe the commercialization of food derived from genetically modified plants has been slow because of the complex regulatory process and the concerns of consumers. Risk assessment is focused on potential adverse effects on humans and the environment, which could result from unintended effects of genetic modificati...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Rischer H,Oksman-Caldentey KM

    更新日期:2006-03-01 00:00:00

  • Platelet-Derived Products in Veterinary Medicine: A New Trend or an Effective Therapy?

    abstract::Platelet-derived products (PDPs) have gained popularity, mainly due to their high concentrations of bioactive molecules such as growth factors and cytokines, which play important roles in tissue healing and regeneration. PDPs are obtained through minimally invasive procedures and their therapeutic effect has been wide...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Soares CS,Babo PS,Reis RL,Carvalho PP,Gomes ME

    更新日期:2020-08-28 00:00:00

  • Transgenic plants as vaccine production systems.

    abstract::Transgenic plants that express foreign proteins with industrial or pharmaceutical value represent an economical alternative to fermentation-based production systems. Specific vaccines have been produced in plants as a result of the transient or stable expression of foreign genes. It has recently been shown that genes ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Mason HS,Arntzen CJ

    更新日期:1995-09-01 00:00:00

  • Autonomous surveillance for biosecurity.

    abstract::The global movement of people and goods has increased the risk of biosecurity threats and their potential to incur large economic, social, and environmental costs. Conventional manual biosecurity surveillance methods are limited by their scalability in space and time. This article focuses on autonomous surveillance sy...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Jurdak R,Elfes A,Kusy B,Tews A,Hu W,Hernandez E,Kottege N,Sikka P

    更新日期:2015-04-01 00:00:00