Combining bio- and chemo-catalysis: from enzymes to cells, from petroleum to biomass.


:In the future, biomass will continue to emerge as a viable source of chemicals. The development of new industries that utilize bio-renewables provides opportunities for innovation. For example, bio- and chemo-catalysts can be combined in 'one pot' to prepare chemicals of commercial value. This has been demonstrated using isolated enzymes and whole cells for a variety of chemical transformations. The one-pot approach has been successfully adopted to convert chemicals derived from biomass, and, in our opinion, it has an important role to play in the design of a more sustainable chemical industry. To implement new one-pot bio- and chemo-catalytic processes, issues of incompatibility must be overcome; the strategies for which are discussed in this opinion article.


Trends Biotechnol


Trends in biotechnology


Marr AC,Liu S




Has Abstract


2011-05-01 00:00:00














  • Effect of glycosylation on antibody function: implications for genetic engineering.

    abstract::Antibodies are able to both bind antigens and trigger the responses that eliminate them from circulation. All antibodies are glycosylated at conserved positions in their constant regions, and the presence of carbohydrate can be critical for antigen clearance functions such as complement activation. The structure of th...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Wright A,Morrison SL

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  • Harnessing Prefrontal Cognitive Signals for Brain-Machine Interfaces.

    abstract::Brain-machine interfaces (BMIs) enable humans to interact with devices by modulating their brain signals. Despite impressive technological advancements, several obstacles remain. The most commonly used BMI control signals are derived from the brain areas involved in primary sensory- or motor-related processing. Howeve...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Min BK,Chavarriaga R,Millán JDR

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  • Microbiome Tools for Forensic Science.

    abstract::Microbes are present at every crime scene and have been used as physical evidence for over a century. Advances in DNA sequencing and computational approaches have led to recent breakthroughs in the use of microbiome approaches for forensic science, particularly in the areas of estimating postmortem intervals (PMIs), l...

    journal_title:Trends in biotechnology

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    authors: Metcalf JL,Xu ZZ,Bouslimani A,Dorrestein P,Carter DO,Knight R

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  • Biocatalytic transformations in ionic liquids.

    abstract::Room temperature ionic liquids are non-volatile, thermally stable and highly polar; they are also moderately hydrophilic solvents. Here, we discuss their use as reaction media for biocatalysis. Enzymes of widely diverging types are catalytically active in ionic liquids or aqueous biphasic ionic liquid systems. Lipases...

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    pub_type: 杂志文章,评审


    authors: van Rantwijk F,Madeira Lau R,Sheldon RA

    更新日期:2003-03-01 00:00:00

  • Nanosilver as a new generation of nanoproduct in biomedical applications.

    abstract::Nanosilver (NS), comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that NS has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Chaloupka K,Malam Y,Seifalian AM

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  • Respectful Modeling: Addressing Uncertainty in Dynamic System Models for Molecular Biology.

    abstract::Although there is still some skepticism in the biological community regarding the value and significance of quantitative computational modeling, important steps are continually being taken to enhance its accessibility and predictive power. We view these developments as essential components of an emerging 'respectful m...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Tsigkinopoulou A,Baker SM,Breitling R

    更新日期:2017-06-01 00:00:00

  • Detecting single-base mutations.

    abstract::The ability to detect single-base changes is of fundamental importance in molecular genetics. This is particularly true in human genetics, where interest in linking mutations of identified genes to particular disease phenotypes is most intense, and where a demand exists for clinical diagnosis of defined mutations. In ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Prosser J

    更新日期:1993-06-01 00:00:00

  • Mutasynthesis - uniting chemistry and genetics for drug discovery.

    abstract::Mutasynthesis couples the power of chemical synthesis with molecular biology to generate derivatives of medicinally valuable, natural products. Recently, this technique has been exploited by Cambridge-based biotech company Biotica Technology Ltd, and their collaborators, to generate promising new variants of the polyk...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Weissman KJ

    更新日期:2007-04-01 00:00:00

  • Using Prokaryotes for Carbon Capture Storage.

    abstract::Geological storage of CO2 is a fast-developing technology that can mitigate rising carbon emissions. However, there are environmental concerns with the long-term storage and implications of a leak from a carbon capture storage (CCS) site. Traditional monitoring lacks clear protocols and relies heavily on physical meth...

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    pub_type: 杂志文章


    authors: Hicks N,Vik U,Taylor P,Ladoukakis E,Park J,Kolisis F,Jakobsen KS

    更新日期:2017-01-01 00:00:00

  • Applications of pHLIP Technology for Cancer Imaging and Therapy.

    abstract::Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, such as antibody targeting. The pH (low) insertion peptides (pHLIP®s) provide new opportunities for targeting acidic tissues. Through the physical mechanism of membran...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Wyatt LC,Lewis JS,Andreev OA,Reshetnyak YK,Engelman DM

    更新日期:2017-07-01 00:00:00

  • Bioelectrochemical Power-to-Gas: State of the Art and Future Perspectives.

    abstract::Bioelectrochemical power-to-gas (BEP2G) is considered a potentially convenient way of storing renewable surplus electricity in the form of methane. In methane-producing bioelectrochemical systems (BESs), carbon dioxide and electrical energy are converted into methane, using electrodes that supply either electrons or h...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Geppert F,Liu D,van Eerten-Jansen M,Weidner E,Buisman C,Ter Heijne A

    更新日期:2016-11-01 00:00:00

  • Knowledge discovery in gene-expression-microarray data: mining the information output of the genome.

    abstract::A key aspect of the genomics revolution is the transformation of large amounts of biological information into an electronic format, leading to an information-based approach to biomedical problems. Large-scale RNA assays and gene-expression-microarray studies, in particular, represent the second wave of the genomics re...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Zweiger G

    更新日期:1999-11-01 00:00:00

  • Isolating ligands specific for human vasculature using in vivo phage selection.

    abstract::The endothelium lining blood vessels expresses molecules that are restricted in their expression to a particular tissue or organ. These molecules are attractive targets for therapy and diagnosis because they allow agents to be delivered specifically to the blood vessels supplying the desired tissue. However, it is dif...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: George AJ,Lee L,Pitzalis C

    更新日期:2003-05-01 00:00:00

  • The Emerging Role of Gas Plasma in Oncotherapy.

    abstract::Atmospheric pressure gas plasmas are emerging as a promising treatment in cancer that can supplement the existing set of treatment modalities and, when combined with other therapies, enhance their selectivity and efficacy against resistant cancers. With further optimisation in production and administration of plasma t...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Dai X,Bazaka K,Richard DJ,Thompson ERW,Ostrikov KK

    更新日期:2018-11-01 00:00:00

  • Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis.

    abstract::Stem cell differentiation is regulated by the complex interplay of multiple parameters, including adhesive intercellular interactions, cytoskeletal and extracellular matrix remodeling, and gradients of agonists and antagonists that individually and collectively vary as a function of spatial locale and temporal stages ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Kinney MA,McDevitt TC

    更新日期:2013-02-01 00:00:00

  • Quality assurance mechanisms for the unregulated research environment.

    abstract::Discussions on research quality and reproducibility are appearing in the pages of scientific journals with heightened significance and gaining media attention. Many institutions have developed guidelines to address the topic of quality in basic research, but questions remain about how best to implement and monitor com...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Riedl DH,Dunn MK

    更新日期:2013-10-01 00:00:00

  • Three-Dimensional Hierarchical Wrinkles on Polymer Films: From Chaotic to Ordered Antimicrobial Topographies.

    abstract::Microbial contamination of polymer surfaces has become a significant challenge in domestic, industrial, and biomedical applications. Recent progress in our understanding of how topographical features of different length scales can be used to effectively and selectively control the attachment and proliferation of diffe...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Nguyen DHK,Bazaka O,Bazaka K,Crawford RJ,Ivanova EP

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  • Alginate as immobilization matrix for cells.

    abstract::In recent years, entrapment of cells within spheres of Ca2+ alginate has become the most widely used technique for immobilizing living cells. This versatile method includes applications ranging from immobilization of living or dead cells in bioreactors, immobilization of plant protoplasts for micropropagation and immo...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Smidsrød O,Skjåk-Braek G

    更新日期:1990-03-01 00:00:00

  • Imaging techniques in the analysis of brain function and behaviour.

    abstract::Techniques such as positron-emission tomography, single-photon-emission computed tomography, functional magnetic-resonance imaging and magnetoencephalography permit the observation of biological processes in the brain in a noninvasive manner. They have yielded new insights into the biological interrelations of sensory...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Müller-Gärtner HW

    更新日期:1998-03-01 00:00:00

  • Modular protein engineering for non-viral gene therapy.

    abstract::Despite the recognized potential of viral vectors for gene therapy, growing biological concerns are prompting the exploration of safer, non-viral vectors to deliver therapeutic nucleic acids. In this context, recombinant proteins can be bioproduced on a large scale, without the need for further in vitro modifications,...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Arís A,Villaverde A

    更新日期:2004-07-01 00:00:00

  • Toward nanoscale genome sequencing.

    abstract::This article reports on the state-of-the-art technologies that sequence DNA using miniaturized devices. The article considers the miniaturization of existing technologies for sequencing DNA and the opportunities for cost reduction that 'on-chip' devices can deliver. The ability to construct nano-scale structures and p...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Ryan D,Rahimi M,Lund J,Mehta R,Parviz BA

    更新日期:2007-09-01 00:00:00

  • Phase and antigenic variation--the impact on strategies for bacterial vaccine design.

    abstract::Many pathogens have the ability to vary the antigenic composition of surface-associated antigens. Often, this variation is mediated by the regulation of gene expression. By varying its antigenicity, the pathogen is able to avoid host immune responses more efficiently; however, this makes the design of vaccines against...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Maskell D,Frankel G,Dougan G

    更新日期:1993-12-01 00:00:00

  • Towards a 'universal' nucleant for protein crystallization.

    abstract::The expression 'crystal clear' stems from the science of crystallography, which determines the detailed atomic structures of materials by exposing crystals to X-rays. Protein structures are pivotal to the success of rational drug design and other biotechnology applications; however, obtaining high quality crystals pos...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Saridakis E,Chayen NE

    更新日期:2009-02-01 00:00:00

  • Emerging Biomedical Applications of Enzyme-Like Catalytic Nanomaterials.

    abstract::Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recen...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Cormode DP,Gao L,Koo H

    更新日期:2018-01-01 00:00:00

  • Organizing for innovation: towards successful translational research.

    abstract::The current productivity crisis in drug discovery has prompted the pharmaceutical industry to decentralize R&D, which is now more responsive, more flexible and better connected to research in academia and biotechnology firms. Organizational changes are also under way in academia. Universities are expanding their techn...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: West W,Nightingale P

    更新日期:2009-10-01 00:00:00

  • RNAi/CRISPR Screens: from a Pool to a Valid Hit.

    abstract::High-throughput genetic screens interfering with gene expression are invaluable tools to identify gene function and phenotype-to-genotype interactions. Implementing such screens in the laboratory is challenging, and the choice between currently available technologies based on RNAi and CRISPR/Cas9 (CRISPR-associated pr...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Schuster A,Erasimus H,Fritah S,Nazarov PV,van Dyck E,Niclou SP,Golebiewska A

    更新日期:2019-01-01 00:00:00

  • Bioencapsulation within synthetic polymers (Part 1): sol-gel encapsulated biologicals.

    abstract::Since its inception a decade ago, sol-gel encapsulation has opened up an intriguing new way to immobilize biological materials. An array of substances, including catalytic antibodies, DNA, RNA, antigens, live bacterial, fungal, plant and animal cells and whole protozoa, have been encapsulated in silica, metal-oxide, o...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Gill I,Ballesteros A

    更新日期:2000-07-01 00:00:00

  • Dynamic transcriptome of mice.

    abstract::Life science in the 21st century is developing rapidly through the structural analysis of biomolecules, the completion of the human genome sequence and the analysis of transcriptomes. The mouse transcriptome has been comprehensively analyzed using a gene discovery approach to collect full-length cDNA (FL-cDNA) clones....

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Hayashizaki Y,Kanamori M

    更新日期:2004-04-01 00:00:00

  • Dkk-1-mediated expansion of adult stem cells.

    abstract::Despite the wealth of research on stem-cell biology and therapy, there have been few advances in the ex vivo expansion of adult stem cells. Fetal bovine serum, which can elicit an immune reaction in hosts receiving cellular products, remains essential to the culture methods. Recent work by Prockop et al. suggests that...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Horwitz EM

    更新日期:2004-08-01 00:00:00

  • Genomics-Driven Natural Product Discovery in Actinomycetes.

    abstract::The prevalence of antimicrobial-resistant pathogens has highlighted the urgent need for new drugs. Actinomycetes have been the most prominent sources of natural products for drug discovery and development. Advances in genomics have inspired several emerging strategies to reinvigorate the field of natural product disco...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Niu G

    更新日期:2018-03-01 00:00:00