Abstract：
:Genetic engineering methods based on the use of transgenes have been successfully adopted to improve crops. A novel all-native DNA gene technology consists of the creation of intragenic constructs by isolating genetic elements from a crop, rearranging them in vitro, and inserting them back into the plant. The ever-increasing genomic information and the elucidation of the molecular mechanisms that control fruit development could be exploited to confer the desired fruit phenotypes using endogenous DNA. The spatial/temporal regulation of genes can be modified by using appropriate endogenous regulatory elements, such as fruit-specific promoters. In addition, intragenic silencing can be employed to downregulate fruit-related genes. Here, we describe the available tools for intragenic manipulation of early phases of fleshy fruit initiation.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Molesini B,Pii Y,Pandolfini Tdoi
10.1016/j.tibtech.2011.07.005subject
Has Abstractpub_date
2012-02-01 00:00:00pages
80-8issue
2eissn
0167-7799issn
1879-3096pii
S0167-7799(11)00135-1journal_volume
30pub_type
杂志文章,评审abstract：:Regulations regarding health claims made for probiotics demand their proven effectiveness and limit the array of microbial species regarded as safe for live consumption. Novel strategies such as moving to postbiotics and genetically modified probiotics may be necessary to increase the effectiveness of microbial produc...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2015.01.006
更新日期：2015-04-01 00:00:00
abstract：:One of the goals of synthetic biology is to build regulatory circuits that control cell behavior, for both basic research purposes and biomedical applications. The ability to build transcriptional regulatory devices depends on the availability of programmable, sequence-specific, and effective synthetic transcription f...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2015.12.014
更新日期：2016-07-01 00:00:00
abstract：:Carotenoids are antioxidants with considerable pharmaceutical potential. More than 600 carotenoid structures are known but their availability is limited owing to practical difficulties associated with chemical synthesis and isolation from microorganisms or plant tissue. To overcome some of these problems, heterologous...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/s0167-7799(99)01307-4
更新日期：1999-06-01 00:00:00
abstract：:There are many paths toward effective microbial inoculants for agriculture. Considering what is practical for the present day technological and farming landscape should not limit our creativity in developing innovative technologies. However, factors including production costs, practicality of implementation, and techn...
journal_title：Trends in biotechnology
pub_type： 评论,信件
doi：10.1016/j.tibtech.2019.02.009
更新日期：2019-06-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章
doi：10.1016/j.tibtech.2013.06.007
更新日期：2013-10-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/s0167-7799(00)01572-9
更新日期：2001-04-01 00:00:00
abstract：:Modern biocatalysis is developing new and precise tools to improve a wide range of production processes, which reduce energy and raw material consumption and generate less waste and toxic side-products. Biocatalysis is also achieving new advances in environmental fields, from enzymatic bioremediation to the synthesis ...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2006.04.002
更新日期：2006-06-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/s0167-7799(00)01457-8
更新日期：2000-07-01 00:00:00
abstract：:The announcement that the European Union (EU) had reached an agreement allowing Member States (MS) to ban genetically modified (GM) crops confirms that the EU has chosen to ignore the food security challenge issued to the world by the Food and Agriculture Organization of the United Nations (FAO) in 2009. The FAO sugge...
journal_title：Trends in biotechnology
pub_type： 杂志文章
doi：10.1016/j.tibtech.2016.04.003
更新日期：2016-07-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2013.06.004
更新日期：2013-10-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2017.03.014
更新日期：2017-07-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章
doi：10.1016/j.tibtech.2013.01.015
更新日期：2013-06-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/S0167-7799(03)00008-8
更新日期：2003-03-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章
doi：10.1016/j.tibtech.2017.10.009
更新日期：2018-03-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2011.01.004
更新日期：2011-05-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章
doi：10.1016/j.tibtech.2004.07.004
更新日期：2004-09-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2018.05.006
更新日期：2018-10-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章
doi：10.1016/j.tibtech.2013.02.001
更新日期：2013-05-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2010.09.004
更新日期：2010-12-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章
doi：10.1016/S0167-7799(03)00143-4
更新日期：2003-07-01 00:00:00
abstract：:Flow cytometry is a rapid method for the quantitative measurement of light scattering and fluorescent properties of cells. Although this technique has been widely applied to biomedical and environmental studies, its potential as a tool in ecotoxicological studies has not yet been fully exploited. This article describe...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/s0167-7799(01)01924-2
更新日期：2002-04-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2020.08.002
更新日期：2020-09-07 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章
doi：10.1016/s0167-7799(02)00022-7
更新日期：2003-02-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章
doi：10.1016/j.tibtech.2014.03.007
更新日期：2014-07-01 00:00:00
abstract：:Small interfering RNAs (siRNAs) have been shown to effectively downregulate gene expression in human cells, giving them potential to eradicate disease. Prospects for clinical applications are discussed in this review, along with an overview of recent history and our current understanding of siRNAs used for therapeutic...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2010.07.009
更新日期：2010-11-01 00:00:00
abstract：:Nanosilver (NS), comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that NS has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings ...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2010.07.006
更新日期：2010-11-01 00:00:00
abstract：:Engineered tissues need a vascular network to supply cells with nutrients and oxygen after implantation. A network that can connect to the vasculature of the patient after implantation can be included during in vitro culture. For optimal integration, this network needs to be highly organized, including venules, capill...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2016.03.002
更新日期：2016-09-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/s0167-7799(01)01701-2
更新日期：2001-09-01 00:00:00
abstract：:The need for companion diagnostics, point-of-care testing (POCT) and high-throughput screening in clinical diagnostics and personalized medicine has pushed the need for more biological information from a single sample at extremely low concentrations and volumes. Optical biosensors based on semiconductor quantum dots (...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2012.04.005
更新日期：2012-07-01 00:00:00
abstract：:Selective delivery of lethal levels of drugs to tumors, without concomitant damage to normal tissues, is a major challenge in cancer chemotherapy. Prodrugs used in conjunction with enzyme-monoclonal antibody conjugates that can target tumors and convert prodrugs to their active drug forms in situ, offer exceptional pr...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/0167-7799(94)90122-8
更新日期：1994-06-01 00:00:00
