MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.

Abstract:

OBJECTIVE:To investigate the matrix metalloproteinase (MMP)-13 expression in associated and non-nevoid basal cell carcinoma syndrome (NBCCS) Odontogenic Keratocysts (OCKs) in order to contribute to a better understanding of the differences in the growth pattern between them. MATERIALS AND METHODS:Thirty-nine paraffin-embedded blocks of OCKs, 26 sporadic OCKs and 11 NBCCS-associated KCOTs were studied by immunohistochemistry to evaluate MMP-13 expression both in epithelial and stromal layers. A semi-quantitative scale was used to evaluate immunostaining. Obtained data were compared between the two groups, using Fischer's exact test and the chi-square test. RESULTS:Only 13 of 26 sporadic OCKs showed a positive immunostaining, whilst 11 KCOTs resulted in positive labelling for MMP-13 expression. Moreover, syndromic cysts displayed a more intense and diffuse MMP-13 labelling of the stromal tissue. Instead, in non-syndromic forms, the staining pattern of MMP-13 in stromal tissue was completely absent. Fisher's exact test showed a statistically significant greater prevalence of KCOTs-immunolabelled cysts with respect to sporadic OCKs. CONCLUSIONS:Results from this study point out that the biological behaviour of these cysts could be related not only to the epithelial layer but also to stromal tissue in that... MMP-13 overexpression in stromal tissue of NBCCS-associated KCOTs could clarify the higher aggressiveness of these cysts.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Leonardi R,Matthews JB,Caltabiano R,Greco M,Lombardo C,Loreto C,Santarelli A,Lo Muzio L

doi

10.1111/j.1601-0825.2010.01690.x

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

795-800

issue

8

eissn

1354-523X

issn

1601-0825

pii

ODI1690

journal_volume

16

pub_type

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