The effect of a sodium lauryl sulfate-free dentifrice on patients with recurrent oral ulceration.

Abstract:

OBJECTIVE:Sodium lauryl sulphate (SLS) is the most commonly used detergent in dentifrices. Recent reports have suggested that it may exacerbate conditions with compromised epithelial integrity. The aim of this study was to compare the effect of an SLS-free dentifrice and an SLS-containing dentifrice on recurrent oral ulceration (ROU). DESIGN:A double-blind crossover clinical trial was carried out during which subjects used an SLS dentifrice for 8 weeks and an SLS-free dentifrice for 8 weeks. Each phase was preceded by a 2-week washout period. SETTING:A UK dental teaching hospital. SUBJECTS AND METHODS:Forty-seven subjects completed the trial. They were all in the age range 10-62 years, had regularly recurrent oral ulceration reporting at least one to two ulcers per month and had normal levels of vitamin B12, ferritin and folate. MAIN OUTCOME MEASURES:The trial phases were compared for the following ulcer parameters--number of ulcer days, total pain scores, number of ulcer episodes, and number of ulcers. Additional parameters compared were the number of ulcers per episode, ulcer duration, total pain per episode and ulcer size. RESULTS:None of the ulcer parameters measured was significantly affected by the use of the SLS-free dentifrice as compared with the SLS dentifrice. CONCLUSION:SLS-free dentifrice had no significant effect on ulcer pattern in the ROU study group.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Healy CM,Paterson M,Joyston-Bechal S,Williams DM,Thornhill MH

doi

10.1111/j.1601-0825.1999.tb00062.x

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

39-43

issue

1

eissn

1354-523X

issn

1601-0825

journal_volume

5

pub_type

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