The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.

abstract：OBJECTIVE: This study is aimed to investigate the association between OLP susceptibility and clinical type in the Thai population and three polymorphisms within the promoter region of the TNF-α at positions -863, -308 and -238 which have putative functional significances. MATERIALS AND METHODS: Genomic DNA from 75 Tha...

journal_title：Oral diseases

authors： Kimkong I,Hirankarn N,Nakkuntod J,Kitkumthorn N

更新日期：2011-03-01 00:00:00

abstract：:Oral Diseases (2011) 17, 252-257 Heme oxygenase (HO) system catabolizes heme into three products: carbon monoxide (CO), biliverdin/bilirubin and free iron, which consists of three forms identified to date: the oxidative stress-inducible protein HO-1 and the constitutive isozymes HO-2 and HO-3. HO has been involved in ...

journal_title：Oral diseases

authors： Fan W,Huang F,Zhu X,Li D,Fu S,He H

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To explore the role of CD10 in cisplatin resistance of oral squamous cell carcinoma (OSCC) and its association with the Hedgehog (Hh) signaling pathway and cancer stem cells (CSCs). METHODS:The correlation between cell viability and CD10 expression was analyzed in different OSCC cell lines after the cisplati...

journal_title：Oral diseases

authors： Wang Y,Li Q,Xu L,Chen J,Pu Y,Wang L,Sun H,Guo Y,Guo C

更新日期：2020-10-09 00:00:00

abstract：:Apical periodontitis (AP) is a prevalent infectious and inflammatory disorder that involves inflammation of periapical tissues and the disintegration of alveolar bone. AP may eventually lead to tooth loss if not timely treated. This disease is caused by pathogenic bacteria in the necrotic pulps and root canals, thereb...

journal_title：Oral diseases

authors： Wei L,Xu M,Xiong H

更新日期：2020-06-02 00:00:00

abstract：OBJECTIVES:Autosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI) shows phenotypic heterogeneity. Our aim was to characterise the ADHCAI phenotypes, tooth properties and genotypes. METHODS:Three unrelated ADHCAI probands and seven additional affected members of the three families were recruited. Mutations w...

journal_title：Oral diseases

authors： Sriwattanapong K,Nitayavardhana I,Theerapanon T,Thaweesapphithak S,Chantarawaratit PO,Garuyakich R,Phokaew C,Porntaveetus T,Shotelersuk V

更新日期：2021-01-24 00:00:00

abstract：OBJECTIVES:To study the response to in vitro priming of peripheral neutrophils from patients with periodontitis compared to healthy controls. Peripheral neutrophils from these patients had shown increased production of oxygen radicals after activation with opsonized bacteria and a difference in priming response could s...

journal_title：Oral diseases

authors： Gustafsson A,Asman B,Bergström K

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To assess the effect of adjunctive use of modified cold-atmospheric pressure plasma (MCAP) to surgically mechanical debridement (MD) on peri-implantitis (PI) in beagles. MATERIAL AND METHODS:Bilateral mandibles of beagles with PI, which induced by cotton ligature twined with steel in sub-marginal around the ...

journal_title：Oral diseases

authors： Zhou X,Wu D,Liang D,Zhang W,Shi Q,Cao Y

更新日期：2020-12-15 00:00:00

abstract：OBJECTIVE:We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP). METHODS:Patients with RAS (n = 15) and LP (n = 18) an...

journal_title：Oral diseases

authors： Hijazi K,Morrison RW,Mukhopadhya I,Martin B,Gemmell M,Shaw S,Santoro F

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Clastic cells, originating from the monocyte-macrophage lineage, resorb mineralized tissues. In periapical periodontitis, alveolar bone around the tooth apex becomes resorbed; however, the roots of the teeth are often left intact by yet unknown mechanisms. Here, we examined the status of clastic cells in a...

journal_title：Oral diseases

authors： Shah A,Lee D,Song M,Kim S,Kang MK,Kim RH

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:We aimed to investigate BRAF V600E percentage immunohistochemically in ameloblastomas of a single institute cohort. We were interested if age, location, histological properties, or tumor recurrence depend on the BRAF status. SUBJECTS, MATERIALS AND METHODS:We had 36 formalin-fixed, paraffin-embedded amelobl...

journal_title：Oral diseases

authors： Kelppe J,Thorén H,Ristimäki A,Haglund C,Sorsa T,Hagström J

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:We assessed the aetiology of idiopathic condylar resorption by examining the effects of oestrogen and compressive mechanical stress under a low systemic oestrogen condition in temporomandibular joints (TMJ) caused by an ovariectomy. MATERIALS AND METHODS:Female rabbits were divided into non-ovariectomy (non-...

journal_title：Oral diseases

authors： Nogami S,Yamauchi K,Odashima K,Ito K,Iikubo M,Kumasaka A,Martinez-de la Cruz G,Gaggl A,Kumamoto H,Takahashi T

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Transforming growth factor-beta (TGF-β) proteins are involved in epithelial keratinization. The major function of latent TGF-β binding proteins (LTBPs) is modulating TGF-β activity. However, whether LTBP-1 and LTBP-2 play roles in gingiva keratinization remains unclear. MATERIALS AND METHODS:Human keratinize...

journal_title：Oral diseases

authors： Chiang MS,Yang JR,Liao SC,Hsu CC,Hsu CW,Yuan K

更新日期：2015-09-01 00:00:00

abstract：:In order for chairside diagnostic testing to make an impact on dental therapy, practitioners require a better understanding of genetic mutations contributing to the pathophysiology of periodontal disease. Commensal and pathogenic bacterial colonization in oral cavity tissues produces a cascade of proinflammatory signa...

journal_title：Oral diseases

authors： Rudick CP,Lang MS,Miyamoto T

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Periodontal and cardiovascular diseases share some common underlying mechanisms. Hyperlipidemia is a major risk factor for cardiovascular diseases. This study sought to assess the association of hyperlipidemia and statin consumption with periodontal status. MATERIALS AND METHODS:This cross-sectional study w...

journal_title：Oral diseases

authors： Sayar F,Fallah S,Akhondi N,Jamshidi S

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:To examine seasonal variations in the presentation of acute necrotising ulcerative gingivitis (ANUG) in a previously unstudied population in Cape Town, South Africa. DESIGN:A descriptive study of all presenting cases of ANUG at a health center over 6 years; patients were examined at one point in time. SETT...

journal_title：Oral diseases

authors： Arendorf TM,Bredekamp B,Cloete CA,Joshipura K

更新日期：2001-05-01 00:00:00

abstract：:Submandibular gland excision is generally performed through a transcervical approach, a safe procedure that, however, carries few neurological, functional and aesthetic drawbacks. Intraoral approach to the submandibular gland has been described many years ago but it has been newly proposed in recent years thanks to en...

journal_title：Oral diseases

authors： Cammaroto G,Vicini C,Montevecchi F,Bonsembiante A,Meccariello G,Bresciani L,Pelucchi S,Capaccio P

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Initial dental caries often occurs in clinic. Reduction of cariogenic bacteria and promotion of remineralization are effective ways to control them. This study was to develop bifunctional anticaries peptides with antibacterial and remineralizing properties. METHODS:We designed peptides TDH19, TNH19, and TVH...

journal_title：Oral diseases

authors： Wang X,Wang Y,Wang K,Ren Q,Li H,Zheng S,Niu Y,Zhou X,Li W,Zhang L

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the cysteine protease inhibitory properties of the human salivary cystatins S, SA and SN in order to identify potential in vivo target cysteine proteases which may include those involved in periodontal tissue destruction. In addition, the potential role of the salivar...

journal_title：Oral diseases

authors： Baron A,DeCarlo A,Featherstone J

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:We assessed the periodontal situation radiologically according to tumour p16 status. MATERIALS AND METHODS:Patients with a diagnosis of tonsillar cancer and availability of a digital panoramic radiograph (DPR) during a 5-year period were included in this retrospective study. The predictor variables were per...

journal_title：Oral diseases

authors： Keinänen A,Marinescu-Gava M,Uittamo J,Hagström J,Marttila E,Snäll J

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:The role of structural and host defensive cells in periapical lesions has been assessed previously by morphometric and immunohistochemical studies. The aim of this study was to investigate the function of peri- apical cells by employing molecular techniques to estimate the cell synthetic activity, proliferati...

journal_title：Oral diseases

authors： Takahashi K,MacDonald D,Murayama Y,Kinane D

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVES:The primary aim of this study was to compare a new mouthwash (SB12®) containing 0.025% chlorhexidine and 0.3% zinc for oral malodor reduction against four commercially available mouthwashes and negative control. A secondary aim was to compare the two methods for measuring volatile sulphur compounds (VSC) by ...

journal_title：Oral diseases

authors： Saad S,Greenman J,Shaw H

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:To investigate whether saliva formulations with reduced calcium (Ca) and inorganic phosphorous (Pi) concentration would affect dental erosion caused by hydrochloric acid (HCl). METHODS:Enamel and root dentine bovine slabs were embedded, polished, and measured for surface Knoop microhardness (SMH). After ref...

journal_title：Oral diseases

authors： Denucci GC,Mantilla TF,Amaral F,Basting RT,França F,Turssi CP

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms underlying the development of dysplasia in leukoplakia are unknown. We used RNA sequencing to examine the molecular and biological pathway differences in oral leukoplakia with and without oral epithelial dysplasia. MATERIALS AND METHODS:Excisional biopsy specimens (25) were taken fro...

journal_title：Oral diseases

authors： Farah CS,Fox SA

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To review a series of patients with sore, burning mouth treated with alpha-lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms. DESIGN:Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients...

journal_title：Oral diseases

authors： Steele JC,Bruce AJ,Drage LA,Rogers RS 3rd

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent an...

journal_title：Oral diseases

authors： Schneider S,Thurnher D,Kadletz L,Seemann R,Brunner M,Kotowski U,Schmid R,Lill C,Heiduschka G

更新日期：2016-11-01 00:00:00

abstract：:The aim of this study was to assess the prevalence of factors associated with oral colonization by Candida spp. in pediatric patients with AIDS. The sample comprised of 117 children. Clinical status, medicines in use, and laboratory findings were obtained from hospital records; sociodemographic data were given by rela...

journal_title：Oral diseases

authors： Domaneschi C,Massarente DB,de Freitas RS,de Sousa Marques HH,Paula CR,Migliari DA,Antunes JL

更新日期：2011-05-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is a common medical condition affecting approximately 35-40% of the adult population in the western world. The role of GERD in causing extra-esophageal symptoms including laryngitis, asthma, cough, chest pain, and dental erosions is increasingly recognized with renewed interest a...

journal_title：Oral diseases

authors： Farrokhi F,Vaezi MF

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:The rationale for using tazarotene in oral lichen planus (OLP) is its regulatory action on the growth and differentiation of keratinocytes and on inflammation. This randomized, placebo-controlled study addresses evaluation of the effects of topic tazarotene in the treatment of OLP. DESIGN:The degree of lesio...

journal_title：Oral diseases

authors： Petruzzi M,De Benedittis M,Grassi R,Cassano N,Vena G,Serpico R

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVES:Fibrosis diseases are one of the leading causes of suffering and death. However, no systematic investigation has been carried out on fibrosis-related genes. MATERIALS AND METHODS:By querying PubMed using keywords "fibrosis" and "gene" or "protein," we identified fibrosis-related genes in the last decade. Bi...

journal_title：Oral diseases

authors： Yuan Y,Li N,Zeng L,Shen Z,Jiang C

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:The establishment of animal models of xenotransplantation can contribute to the elucidation of the molecular pathogenesis of ameloblastic fibrodentinomas (AFD) and it also provides an opportunity for drug tests. We aimed to evaluate the possibility of AFD tumour growth in a patient-derived xenograft (PDX) mo...

journal_title：Oral diseases

authors： Pereira NB,de Souza JC,Bastos VC,Fonseca FP,de Avelar GF,Castro WH,Dias AAM,Mosqueda-Taylor A,Gomez RS,Gomes CC

更新日期：2019-05-01 00:00:00