Bifunctional anticaries peptides with antibacterial and remineralizing effects.

Abstract:

OBJECTIVES:Initial dental caries often occurs in clinic. Reduction of cariogenic bacteria and promotion of remineralization are effective ways to control them. This study was to develop bifunctional anticaries peptides with antibacterial and remineralizing properties. METHODS:We designed peptides TDH19, TNH19, and TVH19 and selected one through comparing their minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) against Streptococcus mutans and their reaction on mineralization. Then the bifunction of the selected peptide was studied through: (a) effects on S. mutans biofilm, (b) remineralizing effects on initial lesions and (c) stability in saliva and cytocompatibility to human oral keratinocytes (HOKs). RESULTS:TVH19 showed the lowest MIC and MBC and a better mineralizing ability. It inhibited new biofilm formation and reduced the viability of old biofilm (p < 0.05). Treating initial caries with TVH19 led to greater recovery of surface microhardness, shallower lesion depth, and higher mineral content (p < 0.05). No significant differences were observed between TVH19 and NaF samples (p > 0.05). TVH19 was stable in saliva and had little effect on HOKs. CONCLUSIONS:The novel bifunctional anticaries peptide TVH19 was developed with remarkable antibacterial activity and the potential to enhance remineralization of initial caries.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Wang X,Wang Y,Wang K,Ren Q,Li H,Zheng S,Niu Y,Zhou X,Li W,Zhang L

doi

10.1111/odi.12990

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

488-496

issue

2

eissn

1354-523X

issn

1601-0825

journal_volume

25

pub_type

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