Pathogenesis investigation of miR-199-5p in oral submucous fibrosis based on bioinformatics analysis.

Abstract:

OBJECTIVES:Fibrosis diseases are one of the leading causes of suffering and death. However, no systematic investigation has been carried out on fibrosis-related genes. MATERIALS AND METHODS:By querying PubMed using keywords "fibrosis" and "gene" or "protein," we identified fibrosis-related genes in the last decade. Bioinformatics analysis was performed by MAS 3.0 software. Key miRNA was selected to assess its relationship with oral submucous fibrosis (OSF) and fibroblast functions. RESULTS:A total of 1,310 genes related to fibrosis were identified. TGF-β1, CTGF, MMP9, HSP47, and S1P were found to be associated with mainly fibrotic organs. In total, 244 cellular components terms, 595 molecular function terms, 1,816 cellular component terms, and 136 KEGG pathway annotations were predicted. miR-199-5p was selected as the key miRNA, which has higher level in OSF. Upregulated miR-199-5p was significantly related to OSF duration and OSF histological grade (p = 0.028 and 0.012, respectively). Overexpressive miR-199-5p reduced proliferation and induced apoptosis in buccal fibroblasts. Additionally, expression levels of collagen I (COL I) and III (COL III) were promoted by overexpressive miR-199-5p in buccal fibroblasts. CONCLUSION:These results indicate that fibrosis-related genes are related to a series of complex mechanisms. The characteristics of miR-199-5p may supply important clues for developing therapeutic strategy for OSF.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Yuan Y,Li N,Zeng L,Shen Z,Jiang C

doi

10.1111/odi.13008

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

456-465

issue

2

eissn

1354-523X

issn

1601-0825

journal_volume

25

pub_type

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    authors: Wahl SM,McNeely TB,Janoff EN,Shugars D,Worley P,Tucker C,Orenstein JM

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