Pathogenesis investigation of miR-199-5p in oral submucous fibrosis based on bioinformatics analysis.


OBJECTIVES:Fibrosis diseases are one of the leading causes of suffering and death. However, no systematic investigation has been carried out on fibrosis-related genes. MATERIALS AND METHODS:By querying PubMed using keywords "fibrosis" and "gene" or "protein," we identified fibrosis-related genes in the last decade. Bioinformatics analysis was performed by MAS 3.0 software. Key miRNA was selected to assess its relationship with oral submucous fibrosis (OSF) and fibroblast functions. RESULTS:A total of 1,310 genes related to fibrosis were identified. TGF-β1, CTGF, MMP9, HSP47, and S1P were found to be associated with mainly fibrotic organs. In total, 244 cellular components terms, 595 molecular function terms, 1,816 cellular component terms, and 136 KEGG pathway annotations were predicted. miR-199-5p was selected as the key miRNA, which has higher level in OSF. Upregulated miR-199-5p was significantly related to OSF duration and OSF histological grade (p = 0.028 and 0.012, respectively). Overexpressive miR-199-5p reduced proliferation and induced apoptosis in buccal fibroblasts. Additionally, expression levels of collagen I (COL I) and III (COL III) were promoted by overexpressive miR-199-5p in buccal fibroblasts. CONCLUSION:These results indicate that fibrosis-related genes are related to a series of complex mechanisms. The characteristics of miR-199-5p may supply important clues for developing therapeutic strategy for OSF.


Oral Dis


Oral diseases


Yuan Y,Li N,Zeng L,Shen Z,Jiang C




Has Abstract


2019-03-01 00:00:00












  • Submandibular gland excision: From external surgery to robotic intraoral and extraoral approaches.

    abstract::Submandibular gland excision is generally performed through a transcervical approach, a safe procedure that, however, carries few neurological, functional and aesthetic drawbacks. Intraoral approach to the submandibular gland has been described many years ago but it has been newly proposed in recent years thanks to en...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Cammaroto G,Vicini C,Montevecchi F,Bonsembiante A,Meccariello G,Bresciani L,Pelucchi S,Capaccio P

    更新日期:2020-07-01 00:00:00

  • Salivary gland malignancies - an update on current management for oral healthcare practitioners.

    abstract::Salivary gland tumours represent a diverse range of tumours with many histological subtypes which occur in major and minor salivary glands. The management of these tumours is complex owing to their heterogeneity. Surgery together with radiotherapy and/or chemotherapy remains the treatment strategy for these tumours. T...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Green B,Rahimi S,Brennan PA

    更新日期:2016-11-01 00:00:00

  • Phosphorylated EGFR at tyrosine 1173 correlates with poor prognosis in oral squamous cell carcinomas.

    abstract:OBJECTIVES:To evaluate the expression of epidermal growth factor receptor (EGFR) and phosphorylated EGFR (pEGFR), in oral squamous cell carcinomas (OSCC). We examined their utility as prognostic markers by relating to clinicopathological characteristics and the clinical outcome. MATERIALS AND METHODS:We analysed 74 pr...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Monteiro L,Ricardo S,Delgado M,Garcez F,do Amaral B,Lopes C

    更新日期:2014-03-01 00:00:00

  • Accumulation of strontium and fluoride in approximal dental plaque and changes in plaque microflora after rinsing with chlorhexidine-fluoride-strontium solution.

    abstract:OBJECTIVES:To find out if strontium is incorporated into plaque and enamel in vivo during a 2-week rinsing period with a chlorhexidine-fluoride-strontium solution and to determine the effects of the rinsing on the numbers of mutans streptococci and lactobacilli in plaque. SUBJECTS AND METHODS:A total of 18 adult parti...

    journal_title:Oral diseases

    pub_type: 临床试验,杂志文章


    authors: Spets-Happonen S,Seppä L,Korhonen A,Alakuijala P

    更新日期:1998-06-01 00:00:00

  • Novel anticoagulants: general overview and practical considerations for dental practitioners.

    abstract::Currently, 4 novel Direct Oral Anticoagulants (DOACs) were approved by the FDA. This review focuses on these agents and proposes a matrix for the general dentists to assess bleeding risk in dental management of patient on DOACs. The outline covers the pharmacology of DOACs (rivaroxaban, apixaban, edoxaban and dabigatr...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Elad S,Marshall J,Meyerowitz C,Connolly G

    更新日期:2016-01-01 00:00:00

  • Efficacy of xenogeneic collagen matrix in the treatment of gingival recessions: A systematic review and meta-analysis.

    abstract:OBJECTIVES:This review aims to evaluate the efficacy of xenogeneic collagen matrix (XCM) for the treatment of single or multiple gingival recessions in terms of clinical parameters and patient-related outcomes. MATERIALS AND METHODS:Various electronic databases (The Cochrane Central Register of Controlled Trials, MEDL...

    journal_title:Oral diseases

    pub_type: 杂志文章,meta分析


    authors: Huang JP,Liu JM,Wu YM,Chen LL,Ding PH

    更新日期:2019-05-01 00:00:00

  • Oral lichen planus: a preliminary clinical study on treatment with tazarotene.

    abstract:OBJECTIVE:The rationale for using tazarotene in oral lichen planus (OLP) is its regulatory action on the growth and differentiation of keratinocytes and on inflammation. This randomized, placebo-controlled study addresses evaluation of the effects of topic tazarotene in the treatment of OLP. DESIGN:The degree of lesio...

    journal_title:Oral diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Petruzzi M,De Benedittis M,Grassi R,Cassano N,Vena G,Serpico R

    更新日期:2002-11-01 00:00:00

  • Clinical, microbiological and ultrastructural features of angular cheilitis lesions in Southern Chinese.

    abstract:OBJECTIVE:To obtain baseline data on angular cheilitis in Southern Chinese. DESIGN:A cross-sectional investigation of the clinical, microbiological and ultrastructural features of the condition. SUBJECTS AND METHOD:Thirty six Chinese adults with angular cheilitis; 28 controls matched for age and sex, with no inflamma...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Dias AP,Samaranayake LP

    更新日期:1995-03-01 00:00:00

  • Priming response to inflammatory mediators in hyperreactive peripheral neutrophils from adult periodontitis.

    abstract:OBJECTIVES:To study the response to in vitro priming of peripheral neutrophils from patients with periodontitis compared to healthy controls. Peripheral neutrophils from these patients had shown increased production of oxygen radicals after activation with opsonized bacteria and a difference in priming response could s...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Gustafsson A,Asman B,Bergström K

    更新日期:1997-09-01 00:00:00

  • Role of oral examination in newly diagnosed multiple myeloma patients: A safe and simple way to detect light chain amyloidosis.

    abstract:OBJECTIVE:Up to 30% of multiple myeloma (MM) patients have subclinical amyloid deposits. These patients are under-recognized and are more susceptible to drug toxicity, bleeding and death. Early diagnosis and adjustment of treatment are crucial. Biopsies of oral mucosa might be a potentially useful diagnostic tool. The ...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Leiba M,Jarjoura S,Abboud W,Nagler A,Yahalom R,Duek A,Yarom N

    更新日期:2018-10-01 00:00:00

  • Collagenases and tissue inhibitors of metalloproteinases: a functional balance in tissue degradation.

    abstract:BACKGROUND:Members of the family of matrix metalloproteinases (MMPs; also called collagenases or matrixins) are key enzymes in matrix degradation. They function at neutral pH and can digest synergistically all the matrix macromolecules. Biochemical and clonal studies indicate that there are three major groups: the spec...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Reynolds JJ

    更新日期:1996-03-01 00:00:00

  • Using next-generation sequencing to detect oral microbiome change following periodontal interventions: A systematic review.

    abstract:OBJECTIVES:This systematic review was to evaluate the change of oral microbiome based on next-generation sequencing (NGS)-metagenomic analysis following periodontal interventions among systematically healthy subjects. MATERIALS AND METHODS:A structured search strategy consisting of "metagenomics" and "oral diseases" w...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Zhang Y,Qi Y,Lo ECM,McGrath C,Mei ML,Dai R

    更新日期:2020-05-11 00:00:00

  • Oral disease in the elderly in long-term hospital care.

    abstract:OBJECTIVE:To obtain baseline information on the prevalence of oral problems and disease in institutionalized elderly in a Scottish hospital. DESIGN:A cross-sectional clinical investigation with complementary microbiological studies as appropriate. SUBJECTS AND METHODS:A cohort of 147 elderly in five long-term care wa...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Samaranayake LP,Wilkieson CA,Lamey PJ,MacFarlane TW

    更新日期:1995-09-01 00:00:00

  • Clastic cells are absent around the root surface in pulp-exposed periapical periodontitis lesions in mice.

    abstract:INTRODUCTION:Clastic cells, originating from the monocyte-macrophage lineage, resorb mineralized tissues. In periapical periodontitis, alveolar bone around the tooth apex becomes resorbed; however, the roots of the teeth are often left intact by yet unknown mechanisms. Here, we examined the status of clastic cells in a...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Shah A,Lee D,Song M,Kim S,Kang MK,Kim RH

    更新日期:2018-03-01 00:00:00

  • Quality of life of family caregivers of children with orofacial clefts in Nigeria: a mixed-method study.

    abstract:BACKGROUND:Orofacial clefts (OFCs) are common birth defects that may impose a large burden on the health and psychosocioeconomic well-being of affected individuals and families. This study aims to identify qualitative factors that affect the quality of life (QOL) of family caregivers of children with OFCs. METHODS:A m...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Awoyale T,Onajole AT,Ogunnowo BE,Adeyemo WL,Wanyonyi KL,Butali A

    更新日期:2016-03-01 00:00:00

  • The effect of smoking on gingival crevicular fluid peptidoglycan recognition protein-1 level following initial periodontal therapy in chronic periodontitis.

    abstract:OBJECTIVE:To determine the effect of smoking on peptidoglycan recognition protein (PGRP)-1 levels in gingival crevicular fluid (GCF) in smokers and non-smokers with chronic periodontitis (CP) following initial periodontal therapy. SUBJECTS AND METHODS:A total of 40 patients with CP (20 smokers (S + CP) and 20 non-smok...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Karsiyaka Hendek M,Kisa U,Olgun E

    更新日期:2020-01-01 00:00:00

  • Deregulation of desmosomal proteins and extracellular matrix proteases in odontogenic keratocyst.

    abstract:OBJECTIVE:Odontogenic keratocyst (OKC) is a benign lesion that tends to recur after surgical treatment. In an attempt to clarify the molecular basis underlining the OKC pathobiology, we aimed to analyze its proteomic profile. MATERIALS AND METHODS:We compared the proteomic profiles of five OKC and matched normal oral ...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Diniz MG,Duarte-Andrade FF,Stussi F,Vitório JG,Fonseca FP,Ramos Domingues R,Paes Leme AF,Gomes CC,Gomez RS

    更新日期:2020-08-09 00:00:00

  • Novel EDA mutation in X-linked hypohidrotic ectodermal dysplasia and genotype-phenotype correlation.

    abstract:OBJECTIVES:X-linked hypohidrotic ectodermal dysplasia (XLHED) is characterized by abnormalities of hair, teeth, and sweat glands, while non-syndromic hypodontia (NSH) affects only teeth. Mutations in Ectodysplasin A (EDA) underlie both XLHED and NSH. This study investigated the genetic causes of six hypohidrotic ectode...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Zeng B,Lu H,Xiao X,Zhou L,Lu J,Zhu L,Yu D,Zhao W

    更新日期:2015-11-01 00:00:00

  • Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.

    abstract:OBJECTIVE:Transforming growth factor-beta (TGF-β) proteins are involved in epithelial keratinization. The major function of latent TGF-β binding proteins (LTBPs) is modulating TGF-β activity. However, whether LTBP-1 and LTBP-2 play roles in gingiva keratinization remains unclear. MATERIALS AND METHODS:Human keratinize...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Chiang MS,Yang JR,Liao SC,Hsu CC,Hsu CW,Yuan K

    更新日期:2015-09-01 00:00:00

  • GLUT-1 in oral benign vascular lesions.

    abstract:AIM:To investigate the accuracy of histological diagnosis of oral hemangioma, oral vascular malformation and oral pyogenic granuloma according to immunohistochemical evaluation of the human erythrocyte-type glucose transporter protein (GLUT-1), and to observe the immunoexpression of this protein in oral varix. MATERIA...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Johann AC,Salla JT,Gomez RS,de Aguiar MC,Gontijo B,Mesquita RA

    更新日期:2007-01-01 00:00:00

  • Individual and contextual determinants of dental pain in adolescents: Evidence from a national survey.

    abstract:OBJECTIVE:To investigate the prevalence of dental pain among adolescent students and its association with individual, school and city variables, using a multilevel approach. SUBJECTS AND METHODS:Individual and school data were obtained from the National Adolescent School-Based Health Survey (PeNSE) conducted in Brazil...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Freire MCM,Nery NG,Jordão LMR,Abreu MHNG

    更新日期:2019-07-01 00:00:00

  • Increased expression of TRPV1 in squamous cell carcinoma of the human tongue.

    abstract:OBJECTIVES:Recent reports have unambiguously identified the presence and the growth-modulatory role of transient receptor potential vanilloid-1 (TRPV1), a central integrator of pain sensation, on numerous non-neuronal cell types and, of great importance, in certain malignancies. In this study, we have investigated the ...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Marincsák R,Tóth BI,Czifra G,Márton I,Rédl P,Tar I,Tóth L,Kovács L,Bíró T

    更新日期:2009-07-01 00:00:00

  • Influence of oestrogen deficiency and excessive mechanical stress on condylar head of mandible.

    abstract:OBJECTIVE:We assessed the aetiology of idiopathic condylar resorption by examining the effects of oestrogen and compressive mechanical stress under a low systemic oestrogen condition in temporomandibular joints (TMJ) caused by an ovariectomy. MATERIALS AND METHODS:Female rabbits were divided into non-ovariectomy (non-...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Nogami S,Yamauchi K,Odashima K,Ito K,Iikubo M,Kumasaka A,Martinez-de la Cruz G,Gaggl A,Kumamoto H,Takahashi T

    更新日期:2020-11-01 00:00:00

  • Periodontitis in tonsil cancer patients-A comparative study in accordance with tumour p16 status.

    abstract:OBJECTIVES:We assessed the periodontal situation radiologically according to tumour p16 status. MATERIALS AND METHODS:Patients with a diagnosis of tonsillar cancer and availability of a digital panoramic radiograph (DPR) during a 5-year period were included in this retrospective study. The predictor variables were per...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Keinänen A,Marinescu-Gava M,Uittamo J,Hagström J,Marttila E,Snäll J

    更新日期:2020-11-01 00:00:00

  • Decreased submandibular adiponectin is involved in the progression of autoimmune sialoadenitis in non-obese diabetic mice.

    abstract:OBJECTIVE:To investigate a possible role of adiponectin in the pathogenesis of autoimmune sialoadenitis in non-obese diabetic (NOD) mouse model of Sjögren's syndrome. MATERIALS AND METHODS:Expression of adiponectin and its receptors (AdipoR1/2) was detected by PCR, immunoblotting, or immunofluorescence. The level of a...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Su YC,Xiang RL,Zhang Y,Ding C,Cong X,Guo XH,Yang NY,Hua H,Wu LL,Yu GY

    更新日期:2014-11-01 00:00:00

  • Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.

    abstract::Despite the presence of HIV-1 in the oral cavity, transmission of the virus through saliva has not been proven. Consistent with these observations, we recently identified an endogenous 12 kD protein, secretory leukocyte protease inhibitor (SLPI), in saliva which blocks HIV-1 infection in vitro. Whereas other salivary ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Wahl SM,McNeely TB,Janoff EN,Shugars D,Worley P,Tucker C,Orenstein JM

    更新日期:1997-05-01 00:00:00

  • Oral cancer: experiences and diagnostic abilities elicited by dentists in North-western Spain.

    abstract:BACKGROUND:Opinions, knowledge, behaviours and attitudes of general dental practitioners on oral cancer prevention and detection have been reported from many countries. However, experiences and skills of oral cancer detection have not been evaluated systematically. OBJECTIVE:To obtain information on behaviours of scre...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Seoane J,Warnakulasuriya S,Varela-Centelles P,Esparza G,Dios PD

    更新日期:2006-09-01 00:00:00

  • Cancer stemness of CD10-positive cells regulated by Hedgehog pathway promotes the resistance to cisplatin in oral squamous cell carcinoma.

    abstract:OBJECTIVE:To explore the role of CD10 in cisplatin resistance of oral squamous cell carcinoma (OSCC) and its association with the Hedgehog (Hh) signaling pathway and cancer stem cells (CSCs). METHODS:The correlation between cell viability and CD10 expression was analyzed in different OSCC cell lines after the cisplati...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Wang Y,Li Q,Xu L,Chen J,Pu Y,Wang L,Sun H,Guo Y,Guo C

    更新日期:2020-10-09 00:00:00

  • Current ideas to reduce or salvage radiation damage to salivary glands.

    abstract::Radiation-induced hyposalivation is still a major problem after radiotherapy for head and neck cancer. Current and promising new thoughts to reduce or salvage radiation damage to salivary gland tissue are explored. The main cause underlying radiation-induced hyposalivation is a lack of functional saliva-producing acin...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Vissink A,van Luijk P,Langendijk JA,Coppes RP

    更新日期:2015-01-01 00:00:00

  • Periodontitis and respiratory diseases: A systematic review with meta-analysis.

    abstract:OBJECTIVE:To conduct a systematic review and meta-analysis to evaluate the recent scientific literature addressing the association between periodontitis and asthma, chronic obstructive pulmonary disease (COPD), and pneumonia. MATERIALS AND METHODS:The search for studies was carried out using MEDLINE/PubMed, EMBASE, Li...

    journal_title:Oral diseases

    pub_type: 杂志文章,meta分析


    authors: Gomes-Filho IS,Cruz SSD,Trindade SC,Passos-Soares JS,Carvalho-Filho PC,Figueiredo ACMG,Lyrio AO,Hintz AM,Pereira MG,Scannapieco F

    更新日期:2020-03-01 00:00:00