Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.

Abstract:

OBJECTIVE:Transforming growth factor-beta (TGF-β) proteins are involved in epithelial keratinization. The major function of latent TGF-β binding proteins (LTBPs) is modulating TGF-β activity. However, whether LTBP-1 and LTBP-2 play roles in gingiva keratinization remains unclear. MATERIALS AND METHODS:Human keratinized gingiva and non-keratinized alveolar mucosa were processed for LTBP-1, LTBP-2, cytokeratin-1 (K1), cytokeratin-4 (K4), and TGF-β immunohistochemical (IHC) staining. Porcine heterotopically transplanted connective tissues and newly grown epithelia were harvested for IHC staining. The expression levels of LTBP-1 and LTBP-2 were compared between differentiated and undifferentiated human normal oral keratinocytes (hNOK). The expression of LTBP-1 and LTBP-2 was knocked down in a cell line (OEC-M1) to evaluate the effects on the expression of K1, K4, and involucrin (INV). RESULTS:In human and porcine specimens, LTBP-2 expression patterns distinguished keratinized and non-keratinized oral epithelia. Western blotting results showed that K1, LTBP-1, and INV proteins were upregulated in differentiated hNOK. In OEC-M1 cells, LTBP-2 knockdown resulted in upregulated the expression of K1 and INV and downregulated the expression of K4. LTBP-1 knockdown resulted in opposite effects. CONCLUSION:The expression patterns of LTBP-2 differ in keratinized gingiva and non-keratinized mucosa. LTBP-1 and LTBP-2 are involved in the keratinization of oral epithelium; however, the underlying mechanism remains to be elucidated.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Chiang MS,Yang JR,Liao SC,Hsu CC,Hsu CW,Yuan K

doi

10.1111/odi.12344

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

762-9

issue

6

eissn

1354-523X

issn

1601-0825

journal_volume

21

pub_type

杂志文章
  • Oral complications at 6 months after radiation therapy for head and neck cancer.

    abstract:OBJECTIVE:To examine oral complications 6 months after modern radiation therapy (RT) for head and neck cancer (HNC). METHODS:Prospective multicenter cohort study of patients with HNC receiving intensity-modulated radiation therapy or more advanced RT. Stimulated whole salivary flow, maximal mouth opening, oral mucosit...

    journal_title:Oral diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1111/odi.12710

    authors: Lalla RV,Treister N,Sollecito T,Schmidt B,Patton LL,Mohammadi K,Hodges JS,Brennan MT,OraRad Study Group.

    更新日期:2017-11-01 00:00:00

  • Oxidative stress and antibody levels to periodontal bacteria in adults: the Nagasaki Islands study.

    abstract:OBJECTIVE:Periodontitis is a chronic inflammatory disease of the tissues supporting the teeth and is caused by subgingival plaque. Systemic increases in reactive oxygen species are involved in pathogenesis of periodontitis. This study addressed the relationship between levels of serum oxidative stress and antibodies ag...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12127

    authors: Tamaki N,Hayashida H,Fukui M,Kitamura M,Kawasaki K,Nakazato M,Maeda T,Saito T,Ito HO

    更新日期:2014-04-01 00:00:00

  • T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction.

    abstract:OBJECTIVE:To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction. METHODS:Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2004.01037.x

    authors: Mutlu N,Erdal ME,Herken H,Oz G,Bayazit YA

    更新日期:2004-11-01 00:00:00

  • Individual and contextual determinants of dental pain in adolescents: Evidence from a national survey.

    abstract:OBJECTIVE:To investigate the prevalence of dental pain among adolescent students and its association with individual, school and city variables, using a multilevel approach. SUBJECTS AND METHODS:Individual and school data were obtained from the National Adolescent School-Based Health Survey (PeNSE) conducted in Brazil...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13100

    authors: Freire MCM,Nery NG,Jordão LMR,Abreu MHNG

    更新日期:2019-07-01 00:00:00

  • Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection.

    abstract:OBJECTIVES:The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus pr...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01612.x

    authors: Andric M,Dozic B,Popovic B,Stefanovic D,Basta-Jovanovic G,Djogo N,Andjus P,Milasin J

    更新日期:2010-03-01 00:00:00

  • The oral health status of dentate patients with chronic renal failure undergoing dialysis therapy.

    abstract:OBJECTIVE:The aim of this study was to compare the oral health status of chronic renal failure (CRF) patients on renal replacement therapy with a matched reference population. DESIGN:Cross-sectional study. SUBJECTS:Forty-two dentate CRF patients--aged 25-52 years old--were matched with a reference group of 808 dentat...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2005.01183.x

    authors: Bots CP,Poorterman JH,Brand HS,Kalsbeek H,van Amerongen BM,Veerman EC,Nieuw Amerongen AV

    更新日期:2006-03-01 00:00:00

  • GLUT-1 in oral benign vascular lesions.

    abstract:AIM:To investigate the accuracy of histological diagnosis of oral hemangioma, oral vascular malformation and oral pyogenic granuloma according to immunohistochemical evaluation of the human erythrocyte-type glucose transporter protein (GLUT-1), and to observe the immunoexpression of this protein in oral varix. MATERIA...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01246.x

    authors: Johann AC,Salla JT,Gomez RS,de Aguiar MC,Gontijo B,Mesquita RA

    更新日期:2007-01-01 00:00:00

  • BRAF V600E expression in ameloblastomas-A 36-patient cohort from Helsinki University Hospital.

    abstract:OBJECTIVES:We aimed to investigate BRAF V600E percentage immunohistochemically in ameloblastomas of a single institute cohort. We were interested if age, location, histological properties, or tumor recurrence depend on the BRAF status. SUBJECTS, MATERIALS AND METHODS:We had 36 formalin-fixed, paraffin-embedded amelobl...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13072

    authors: Kelppe J,Thorén H,Ristimäki A,Haglund C,Sorsa T,Hagström J

    更新日期:2019-05-01 00:00:00

  • Osteoclast activation in inflammatory periodontal diseases.

    abstract:OBJECTIVE:In this paper, we review the mechanisms thought to be involved in the activation of osteoclasts in periodontitis. SUMMARY:Osteoclasts are regulated by both microbial and host factors. Some factors act directly on cells of the osteoclast lineage, whereas others act indirectly through other cell types in the b...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1996.tb00218.x

    authors: Wiebe SH,Hafezi M,Sandhu HS,Sims SM,Dixon SJ

    更新日期:1996-06-01 00:00:00

  • Antibiotic effects on bacterial profile in osteonecrosis of the jaw.

    abstract:OBJECTIVE:Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ), and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues. MATERIALS ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2011.01848.x

    authors: Ji X,Pushalkar S,Li Y,Glickman R,Fleisher K,Saxena D

    更新日期:2012-01-01 00:00:00

  • Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients.

    abstract:OBJECTIVE:Oral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease-specific biomarkers in saliva is an easy, quick, and non-invasive approach for molecular diagnosis. This study was design...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12374

    authors: Byun JS,Hong SH,Choi JK,Jung JK,Lee HJ

    更新日期:2015-11-01 00:00:00

  • Sugars and beyond. The role of sugars and the other nutrients and their potential impact on caries.

    abstract::The traditional concept of caries as a multifactorial transmittable and infectious disease has been challenged. Novel conceptual ideas have come to add to the complexity of this highly prevalent disease worldwide. Current etiological understanding of the disease has emphasized the pivotal role of sugars in caries. In ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12778

    authors: Giacaman RA

    更新日期:2018-10-01 00:00:00

  • Periodontitis and respiratory diseases: A systematic review with meta-analysis.

    abstract:OBJECTIVE:To conduct a systematic review and meta-analysis to evaluate the recent scientific literature addressing the association between periodontitis and asthma, chronic obstructive pulmonary disease (COPD), and pneumonia. MATERIALS AND METHODS:The search for studies was carried out using MEDLINE/PubMed, EMBASE, Li...

    journal_title:Oral diseases

    pub_type: 杂志文章,meta分析

    doi:10.1111/odi.13228

    authors: Gomes-Filho IS,Cruz SSD,Trindade SC,Passos-Soares JS,Carvalho-Filho PC,Figueiredo ACMG,Lyrio AO,Hintz AM,Pereira MG,Scannapieco F

    更新日期:2020-03-01 00:00:00

  • The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is one of the most morbid, mortal, and genetically diverse malignancies. Although HNSCC is heterogeneous in nature, alterations in major components of the PI3K/Akt/mTOR pathway are consistently observed throughout the majority of HNSCC cases. These alterations include gene...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12206

    authors: Vander Broek R,Mohan S,Eytan DF,Chen Z,Van Waes C

    更新日期:2015-10-01 00:00:00

  • Alpha-lipoic acid treatment of 31 patients with sore, burning mouth.

    abstract:OBJECTIVE:To review a series of patients with sore, burning mouth treated with alpha-lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms. DESIGN:Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01414.x

    authors: Steele JC,Bruce AJ,Drage LA,Rogers RS 3rd

    更新日期:2008-09-01 00:00:00

  • Decreased submandibular adiponectin is involved in the progression of autoimmune sialoadenitis in non-obese diabetic mice.

    abstract:OBJECTIVE:To investigate a possible role of adiponectin in the pathogenesis of autoimmune sialoadenitis in non-obese diabetic (NOD) mouse model of Sjögren's syndrome. MATERIALS AND METHODS:Expression of adiponectin and its receptors (AdipoR1/2) was detected by PCR, immunoblotting, or immunofluorescence. The level of a...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12197

    authors: Su YC,Xiang RL,Zhang Y,Ding C,Cong X,Guo XH,Yang NY,Hua H,Wu LL,Yu GY

    更新日期:2014-11-01 00:00:00

  • Oral lichenoid lesions of the upper lip and gingiva: What we know so far.

    abstract::The clinical presentation of oral lichen planus and oral lichenoid lesions is diverse. A special category of patients presents with lichenoid lesions affecting only the mucosa of their upper lip and the anterior upper gingiva. This is a concise review summarizing the specific characteristics of these patients. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12763

    authors: Georgakopoulou EA,Malamos D,Achtari MD

    更新日期:2018-03-01 00:00:00

  • Burning mouth syndrome and oral health-related quality of life: is there a change over time?

    abstract:BACKGROUND:The symptoms associated with burning mouth syndrome can be quite varied and can interfere with the every day lives of patients. Management of the condition can be challenging for clinicians. AIMS:To determine the oral health-related quality of life (OHRQOL) implications of BMS on patients over a period of t...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2010.01666.x

    authors: Ni Riordain R,Moloney E,O'Sullivan K,McCreary C

    更新日期:2010-10-01 00:00:00

  • Poland-Moebius syndrome: a case with oral anomalies.

    abstract::The combination of Moebius and Poland anomalies is rarely described in the literature. While some authors believe this association is an independent syndrome, others think that Poland, Moebius and Poland-Moebius syndromes are variations of the same condition. We report a case of Poland-Moebius syndrome in a 6-year-old...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2004.01045.x

    authors: Domingos AC,Lopes SL,Almeida SM,Boscolo FN,Whaites EJ

    更新日期:2004-11-01 00:00:00

  • Development of novel oligonucleotide probes for seven Actinomyces species and their utility in supragingival plaque analysis.

    abstract:OBJECTIVE:The traditional, biochemical and enzymatic methods of identifying Actinomyces species are frequently confounded by the similar phenotypic characteristics shared by the different members of this genus. Therefore, we developed novel species-specific oligonucleotide probes to accurately speciate seven pathogenic...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2003.02926.x

    authors: Tang G,Yip HK,Luo G,Cheung BP,Shen S,Samaranayake LP

    更新日期:2003-07-01 00:00:00

  • Defensin-1, an antimicrobial peptide present in the saliva of patients with oral diseases.

    abstract:OBJECTIVES AND DESIGN:A preceding paper has noted a detection of defensin-1 (HNP-1), a peptide with antimicrobial and cytotoxic properties, in the saliva of patients with oral squamous cell carcinoma. The present study deals with the presence of HNP-1 in the saliva of patients with various oral diseases. METHODS:Whole...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1999.tb00078.x

    authors: Mizukawa N,Sugiyama K,Ueno T,Mishima K,Takagi S,Sugahara T

    更新日期:1999-04-01 00:00:00

  • Toward gene therapy for growth hormone deficiency via salivary gland expression of growth hormone.

    abstract:OBJECTIVES:Salivary glands are useful targets for gene therapeutics. After gene transfer into salivary glands, regulated secretory pathway proteins, such as human growth hormone, are secreted into saliva, whereas constitutive secretory pathway proteins, such as erythropoietin, are secreted into the bloodstream. Secreti...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12217

    authors: Racz GZ,Zheng C,Goldsmith CM,Baum BJ,Cawley NX

    更新日期:2015-03-01 00:00:00

  • Autophagy inhibits TLR4-mediated invasiveness of oral cancer cells via the NF-κB pathway.

    abstract:OBJECTIVES:Toll-like receptor 4 (TLR4) is abnormally expressed in oral cancer tissues and promotes cancer cell invasion. The purpose of this study was to clarify the mechanism by which autophagy regulates oral cancer invasion through the TLR4-NF-κB pathway. SUBJECTS AND METHODS:We examined TLR4 expression in oral canc...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13355

    authors: Kong Q,Liang Y,He Q,You Y,Wu L,Liang L,Liang J

    更新日期:2020-04-14 00:00:00

  • A nomogram for predicting the risk of neck node metastasis in pathologically node-negative oral cavity carcinoma.

    abstract:OBJECTIVE:To generate a nomogram for predicting the risk of neck node metastasis in pathologically node-negative patients using a combination of variables comprising of protein expression, ultrastructural alterations and clinicopathological parameters. MATERIALS AND METHODS:Surgically removed oral tumours (n = 103) we...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12696

    authors: Sawant SS,Dongre H,Ahire C,Sharma S,Kannan S,Mahadik S,Chaukar D,Lukmani F,Patil A,D'Cruz A,Vaidya MM,Dongre P

    更新日期:2017-11-01 00:00:00

  • Occupational COVID-19 risk to dental staff working in a public dental unit in the outbreak epicenter.

    abstract:OBJECTIVE:The management of the COVID-19 outbreak occurred in Lombardy (Italy) implied that non-COVID-19 health care was remodeled, limiting adequate resources in non-hospital public dental healthcare settings. This situation offered the opportunity to investigate the occupational COVID-19 risk to dental staff in publi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13632

    authors: Nardone M,Cordone A,Petti S

    更新日期:2020-09-03 00:00:00

  • Secretory cells in adenomatoid odontogenic tumour: tissue induction or metaplastic mineralisation?

    abstract:OBJECTIVE:To undertake a detailed histological investigation of a large series of adenomatoid odontogenic tumours (AOT) to document the frequency and histomorphology of secretory cells which might indicate an inductive capacity. MATERIALS AND METHODS:Haematoxylin and eosin stained sections of 51 cases of AOT were revi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01399.x

    authors: Jivan V,Altini M,Meer S

    更新日期:2008-07-01 00:00:00

  • Immunohistochemical demonstration of p63 in DMBA-induced hamster buccal pouch squamous cell carcinogenesis.

    abstract:UNLABELLED:Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family, p73 at the 1p36 region and p63 at the 3q27-29 region, have recently been identified. They share considerable sequence homolog...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2003.02920.x

    authors: Chen YK,Hsue SS,Lin LM

    更新日期:2003-09-01 00:00:00

  • Prevalence of oral disease among adults with primary HIV infection.

    abstract:OBJECTIVE:To explore the type and prevalence of oral mucosal lesions among adults with primary HIV infection (PHI) compared with HIV-negative adults at high risk for HIV disease, and in relation to HIV viral load. METHODS:We conducted standardized oral examinations to identify specific oral mucosal lesions among adult...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01407.x

    authors: Owotade FJ,Shiboski CH,Poole L,Ramstead CA,Malvin K,Hecht FM,Greenspan JS

    更新日期:2008-09-01 00:00:00

  • Immunohistochemistry and gene expression of GLUT1, RUNX2 and MTOR in reparative dentinogenesis.

    abstract:OBJECTIVES:To determine glucose transporter 1 (GLUT1) and runt-related transcription factor 2 (RUNX2) expression during reparative dentinogenesis after pulpotomy with mineral trioxide aggregate (MTA) capping. SUBJECTS AND METHODS:Eight-week-old male Wistar rats were used. Pulp of the upper left first molar was exposed...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13230

    authors: Takeuchi R,Ohkura N,Yoshiba K,Tohma A,Yoshiba N,Edanami N,Shirakashi M,Belal RS,Ohshima H,Noiri Y

    更新日期:2020-03-01 00:00:00

  • Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature.

    abstract:OBJECTIVE:Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of salivary glands with a widely diverse biologic behavior that is correlated with the histological grade of the tumor. The purpose of this study was to evaluate the clinical outcomes of MEC of minor salivary glands in a group of 16 patients, w...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2005.01166.x

    authors: Triantafillidou K,Dimitrakopoulos J,Iordanidis F,Koufogiannis D

    更新日期:2006-07-01 00:00:00