Abstract:
OBJECTIVE:Periodontitis is a chronic inflammatory disease of the tissues supporting the teeth and is caused by subgingival plaque. Systemic increases in reactive oxygen species are involved in pathogenesis of periodontitis. This study addressed the relationship between levels of serum oxidative stress and antibodies against putative periodontopathic bacteria and their association with periodontal conditions, in a community-based study. SUBJECTS AND METHODS:Serum samples were measured for reactive oxygen metabolite (ROM) levels and anti-oxidant capacity. The serum levels of immunoglobulin G (IgG) antibodies to Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Aggregatibacter actinomycetemcomitans (Aa), and Eikenella corrodens (Ec) were determined by ELISA. RESULTS:The participants with greater clinical attachment loss had higher serum ROM levels and IgG antibody titers to Pg. Serum ROM levels were positively correlated with antibody titers to Pg, Pi, and Ec. When the participants with greater probing pocket depth and clinical attachment loss were used as the dependent variables, high ROM levels showed a statistically significant associations in multivariate logistic analyses; the adjusted odds ratios were 2.9 (95% confidence interval = 1.0-8.5) and 6.0 (95% confidence interval = 2.0-17.6), respectively. CONCLUSIONS:It was concluded that an increased oxidative stress may be detrimental to periodontitis in Japanese community-dwelling adults.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Tamaki N,Hayashida H,Fukui M,Kitamura M,Kawasaki K,Nakazato M,Maeda T,Saito T,Ito HOdoi
10.1111/odi.12127subject
Has Abstractpub_date
2014-04-01 00:00:00pages
e49-56issue
3eissn
1354-523Xissn
1601-0825journal_volume
20pub_type
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