Nutritional status in patients of mandibular osteoradionecrosis: A single-institution experience.

Abstract:

BACKGROUND:Mandibular osteoradionecrosis (ORN) is a devastating complication secondary to the radiotherapy of head and neck cancer. The nutritional status of ORN patients is compromised, but remains rarely studied. We aimed to evaluate the overall nutritional status of patients with ORN and explore the risk factors behind poor nutrition. METHODS:This is a single-institution cross-sectional study. Patients diagnosed with ORN were consecutively recruited in a tertiary teaching hospital from July 2017 to August 2019. Multiple laboratory markers and physical indicators were examined to profile their nutritional status. The potential risk factors of poor nutrition were explored by logistic regression. RESULTS:A total of 107 patients with ORN were recruited. Among them, almost all patients (95.3%) had at least one laboratory marker lower than the normal physiological range. A total of 40 (37.5%) patients were categorized as undernutrition, who had lower serum albumin (mean difference: 1.8 ± 0.8 g/L; p = .02), prealbumin (mean difference: 26.8 ± 10.8 mg/L; p = .02), and BMI (3.8 ± 0.4 kg/m2 ; p < .0001) compared to patients of normal nutrition. Notably, the multivariate logistic regression indicated that patients with semi-liquid diet had 14.41 (95% CI: 3.03-68.54, p = .001) times; patients with liquid diet had 5.70 (95% CI: 1.55-20.98, p = .009) times more likely to be in undernutrition, as compared to patients with regular diets. CONCLUSIONS:This is the first study characterizing the poor nutritional status in ORN patients. Patients having semi-liquid or liquid diets tended to have poorer nutritional status. The nutritional status of ORN patients should be underlined for professional nutritional supports so as to enhance their quality of life. More studies are warranted.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Huang Q,He X,Yang WF,Ye J,Lin Z,Xiong C,Liang YJ

doi

10.1111/odi.13762

subject

Has Abstract

pub_date

2020-12-28 00:00:00

eissn

1354-523X

issn

1601-0825

pub_type

杂志文章
  • Novel EDA mutation in X-linked hypohidrotic ectodermal dysplasia and genotype-phenotype correlation.

    abstract:OBJECTIVES:X-linked hypohidrotic ectodermal dysplasia (XLHED) is characterized by abnormalities of hair, teeth, and sweat glands, while non-syndromic hypodontia (NSH) affects only teeth. Mutations in Ectodysplasin A (EDA) underlie both XLHED and NSH. This study investigated the genetic causes of six hypohidrotic ectode...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12376

    authors: Zeng B,Lu H,Xiao X,Zhou L,Lu J,Zhu L,Yu D,Zhao W

    更新日期:2015-11-01 00:00:00

  • A novel mutation in the OFD1 (Cxorf5) gene may contribute to oral phenotype in patients with oral-facial-digital syndrome type 1.

    abstract:BACKGROUND:Oral-facial-digital syndrome (OFDS) type 1 (OFD1) is an X-linked dominant condition associated with embryonic male lethality. It almost always affects the oral cavity, face, and digits. It is considered to be a ciliopathy caused by mutations in the OFD1 gene. A variety of mutations have been described, and a...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2011.01823.x

    authors: Diz P,Alvarez-Iglesias V,Feijoo JF,Limeres J,Seoane J,Tomás I,Carracedo A

    更新日期:2011-09-01 00:00:00

  • Proliferative verrucous leukoplakia: a concise update.

    abstract::Proliferative verrucous leukoplakia (PVL) is of uncertain etiology but may be associated with human papillomavirus (HPV) infection. Proliferative verrucous leukoplakia is seen mainly in older women, beginning as a simple slow-growing, persistent leukoplakia that tends to spread and become multifocal and affect the gin...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2009.01632.x

    authors: Bagan J,Scully C,Jimenez Y,Martorell M

    更新日期:2010-05-01 00:00:00

  • Elder neglect-Oral diseases and injuries.

    abstract::Elder neglect (EN) is the failure of a designated caregiver to meet the needs of a dependent older person. World EN prevalence, meta-analyzed in this study, is 1.0% or 1.8% according to different statistical methods. Referring alleged EN cases to Adult Protective Services (APSs) by healthcare workers (HCWs) is mandato...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12797

    authors: Petti S

    更新日期:2018-09-01 00:00:00

  • Neuralgia-inducing cavitational osteonecrosis: a status report.

    abstract::Neuralgia-inducing cavitational osteonecrosis remains controversial several years following the initial description. Changing etiologic concepts have led to confusion as well as the significant departures from the concept first defined by Ratner which served as the basis for the explaining the pain syndrome with featu...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2009.01532.x

    authors: Sciubba JJ

    更新日期:2009-07-01 00:00:00

  • PKR regulates LPS-induced osteoclast formation and bone destruction in vitro and in vivo.

    abstract:OBJECTIVE:In this study, we aimed to clarify the precise mechanism underlying lipopolysaccharide (LPS)-induced osteoclastogenesis in periodontal disease with a special reference to double-stranded RNA-dependent protein kinase (PKR). MATERIAL AND METHODS:We dissected the role of PKR in LPS-induced osteoclast differenti...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12592

    authors: Teramachi J,Inagaki Y,Shinohara H,Okamura H,Yang D,Ochiai K,Baba R,Morimoto H,Nagata T,Haneji T

    更新日期:2017-03-01 00:00:00

  • DNA methylation in oral squamous cell carcinoma: molecular mechanisms and clinical implications.

    abstract::DNA methylation is an important regulator of gene transcription, and its role in carcinogenesis has been a topic of considerable interest in the last few years. Of the all epigenetic modifications, methylation, which represses transcription of the promoter region of tumor suppressor genes leading to gene silencing, ha...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2011.01833.x

    authors: González-Ramírez I,García-Cuellar C,Sánchez-Pérez Y,Granados-García M

    更新日期:2011-11-01 00:00:00

  • Phosphorylated EGFR at tyrosine 1173 correlates with poor prognosis in oral squamous cell carcinomas.

    abstract:OBJECTIVES:To evaluate the expression of epidermal growth factor receptor (EGFR) and phosphorylated EGFR (pEGFR), in oral squamous cell carcinomas (OSCC). We examined their utility as prognostic markers by relating to clinicopathological characteristics and the clinical outcome. MATERIALS AND METHODS:We analysed 74 pr...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12087

    authors: Monteiro L,Ricardo S,Delgado M,Garcez F,do Amaral B,Lopes C

    更新日期:2014-03-01 00:00:00

  • Defensin-1, an antimicrobial peptide present in the saliva of patients with oral diseases.

    abstract:OBJECTIVES AND DESIGN:A preceding paper has noted a detection of defensin-1 (HNP-1), a peptide with antimicrobial and cytotoxic properties, in the saliva of patients with oral squamous cell carcinoma. The present study deals with the presence of HNP-1 in the saliva of patients with various oral diseases. METHODS:Whole...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1999.tb00078.x

    authors: Mizukawa N,Sugiyama K,Ueno T,Mishima K,Takagi S,Sugahara T

    更新日期:1999-04-01 00:00:00

  • Diagnostic accuracy of Narrow Band Imaging for the detection of oral potentially malignant disorders.

    abstract:OBJECTIVE:To determine the clinical diagnostic accuracy of Narrow Band Imaging(™) for the detection of oral potentially malignant disorders in a prospective series of patients. MATERIALS AND METHODS:New and existing patients referred to an oral medicine and pathology specialist clinic for assessment of at least one wh...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12315

    authors: Vu AN,Matias M,Farah CS

    更新日期:2015-05-01 00:00:00

  • Decreased submandibular adiponectin is involved in the progression of autoimmune sialoadenitis in non-obese diabetic mice.

    abstract:OBJECTIVE:To investigate a possible role of adiponectin in the pathogenesis of autoimmune sialoadenitis in non-obese diabetic (NOD) mouse model of Sjögren's syndrome. MATERIALS AND METHODS:Expression of adiponectin and its receptors (AdipoR1/2) was detected by PCR, immunoblotting, or immunofluorescence. The level of a...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12197

    authors: Su YC,Xiang RL,Zhang Y,Ding C,Cong X,Guo XH,Yang NY,Hua H,Wu LL,Yu GY

    更新日期:2014-11-01 00:00:00

  • Relationship between periodontal disease and male infertility: A case-control study.

    abstract:OBJECTIVES:To compare the prevalence of chronic periodontitis between men who had semen abnormalities and those who had normozoospermia through a case-control study. MATERIALS AND METHODS:Male patients who visited the assisted reproduction clinic of a large general hospital and were diagnosed with semen abnormalities ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13552

    authors: Tao DY,Zhu JL,Xie CY,Kuang YP,Chai WR,Lo ECM,Ye W,Li F,Feng XP,Lu HX

    更新日期:2020-07-23 00:00:00

  • Oral lichenoid lesions of the upper lip and gingiva: What we know so far.

    abstract::The clinical presentation of oral lichen planus and oral lichenoid lesions is diverse. A special category of patients presents with lichenoid lesions affecting only the mucosa of their upper lip and the anterior upper gingiva. This is a concise review summarizing the specific characteristics of these patients. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12763

    authors: Georgakopoulou EA,Malamos D,Achtari MD

    更新日期:2018-03-01 00:00:00

  • Early tooth loss in end-stage renal disease patients on haemodialysis.

    abstract:OBJECTIVE:This article sets out to evaluate the prevalence and aetiopathogenesis of edentulism in patients on haemodialysis. SUBJECTS AND METHODS:The study group comprised 44 adult patients with end-stage renal disease (ESRD) on haemodialysis. A control group was formed of 44 individuals matched for age and sex and wi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12486

    authors: Limeres J,Garcez JF,Marinho JS,Loureiro A,Diniz M,Diz P

    更新日期:2016-09-01 00:00:00

  • Prevalence of six periodontal pathogens detected by DNA probe method in HIV vs non-HIV periodontitis.

    abstract:OBJECTIVE:The aim of the study was to examine the prevalence of selected periodontal pathogens associated with HIV and non-HIV related periodontal lesions. METHODS:Subgingival plaque samples were obtained from both HIV-seropositive and HIV-seronegative patients affected with periodontal disease. DNA probes were used t...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1997.tb00350.x

    authors: Tenenbaum H,Elkaim R,Cuisinier F,Dahan M,Zamanian P,Lang JM

    更新日期:1997-05-01 00:00:00

  • Mouth breathing impairs the development of temporomandibular joint at a very early stage.

    abstract:OBJECTIVES:The study aimed to explore the effects of mouth breathing and hypoxia on the condyle of temporomandibular joint (TMJ) via two animal models. METHODS:24 four-week-old rats were randomly separated into three groups, consisting of eight control rats, eight intermittent hypoxia (IH) rats, and eight intermittent...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13377

    authors: Hu Z,Sun H,Wu Y,Wu X,Mei P,Wang B,Zhu M

    更新日期:2020-10-01 00:00:00

  • Deregulation of desmosomal proteins and extracellular matrix proteases in odontogenic keratocyst.

    abstract:OBJECTIVE:Odontogenic keratocyst (OKC) is a benign lesion that tends to recur after surgical treatment. In an attempt to clarify the molecular basis underlining the OKC pathobiology, we aimed to analyze its proteomic profile. MATERIALS AND METHODS:We compared the proteomic profiles of five OKC and matched normal oral ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13598

    authors: Diniz MG,Duarte-Andrade FF,Stussi F,Vitório JG,Fonseca FP,Ramos Domingues R,Paes Leme AF,Gomes CC,Gomez RS

    更新日期:2020-08-09 00:00:00

  • Cathepsin K modulates invasion, migration and adhesion of oral squamous cell carcinomas in vitro.

    abstract:OBJECTIVE:Cathepsin K was initially discovered as an osteoclast-specific cysteine proteinase, but the enzyme is also expressed in various cancers including oral squamous cell carcinomas. This study aimed to clarify the function of cathepsin K in oral squamous cell carcinomas. MATERIALS AND METHODS:Expression levels of...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12643

    authors: Yamashita K,Iwatake M,Okamoto K,Yamada SI,Umeda M,Tsukuba T

    更新日期:2017-05-01 00:00:00

  • Influence of oestrogen deficiency and excessive mechanical stress on condylar head of mandible.

    abstract:OBJECTIVE:We assessed the aetiology of idiopathic condylar resorption by examining the effects of oestrogen and compressive mechanical stress under a low systemic oestrogen condition in temporomandibular joints (TMJ) caused by an ovariectomy. MATERIALS AND METHODS:Female rabbits were divided into non-ovariectomy (non-...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13452

    authors: Nogami S,Yamauchi K,Odashima K,Ito K,Iikubo M,Kumasaka A,Martinez-de la Cruz G,Gaggl A,Kumamoto H,Takahashi T

    更新日期:2020-11-01 00:00:00

  • MSX1 gene polymorphisms and non-syndromic cleft lip with or without palate (NSCL/P): A meta-analysis.

    abstract:OBJECTIVE:Non-syndromic cleft lip, with or without cleft palate (NSCL/P), is a common craniofacial birth defect, the risk of which is influenced from multiple genetic loci. Association study outcomes between single nucleotide polymorphisms (SNPs) near the muscle segment homeobox gene 1 (MSX1) and NSCL/P have been incon...

    journal_title:Oral diseases

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/odi.13127

    authors: Tasanarong P,Pabalan N,Tharabenjasin P,Jarjanazi H

    更新日期:2019-09-01 00:00:00

  • Increased expression of TRPV1 in squamous cell carcinoma of the human tongue.

    abstract:OBJECTIVES:Recent reports have unambiguously identified the presence and the growth-modulatory role of transient receptor potential vanilloid-1 (TRPV1), a central integrator of pain sensation, on numerous non-neuronal cell types and, of great importance, in certain malignancies. In this study, we have investigated the ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01526.x

    authors: Marincsák R,Tóth BI,Czifra G,Márton I,Rédl P,Tar I,Tóth L,Kovács L,Bíró T

    更新日期:2009-07-01 00:00:00

  • Local drug delivery for oral mucosal diseases: challenges and opportunities.

    abstract::There are few topical formulations used for oral medicine applications most of which have been developed for the management of dermatological conditions. As such, numerous obstacles are faced when utilizing these preparations in the oral cavity, namely enzymatic degradation, taste, limited surface area, poor tissue pe...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2011.01793.x

    authors: Sankar V,Hearnden V,Hull K,Juras DV,Greenberg MS,Kerr AR,Lockhart PB,Patton LL,Porter S,Thornhill M

    更新日期:2011-04-01 00:00:00

  • Solubility properties of human tooth mineral and pathogenesis of dental caries.

    abstract::Dental research over the last century has advanced our understanding of the etiology and pathogenesis of caries lesions. Increasing knowledge of the dynamic demineralization/remineralization processes has led to the current consensus that bacteria-mediated tooth destruction can be arrested or even to some degree rever...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2004.01030.x

    authors: Aoba T

    更新日期:2004-09-01 00:00:00

  • Cell synthesis, proliferation and apoptosis in human dental periapical lesions analysed by in situ hybridisation and immunohistochemistry.

    abstract:OBJECTIVE:The role of structural and host defensive cells in periapical lesions has been assessed previously by morphometric and immunohistochemical studies. The aim of this study was to investigate the function of peri- apical cells by employing molecular techniques to estimate the cell synthetic activity, proliferati...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1999.tb00096.x

    authors: Takahashi K,MacDonald D,Murayama Y,Kinane D

    更新日期:1999-10-01 00:00:00

  • Effects of neratinib and combination with irradiation and chemotherapy in head and neck cancer cells.

    abstract:OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent an...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12552

    authors: Schneider S,Thurnher D,Kadletz L,Seemann R,Brunner M,Kotowski U,Schmid R,Lill C,Heiduschka G

    更新日期:2016-11-01 00:00:00

  • Emerging and changing viral diseases in the new millennium.

    abstract::Most viral infections encountered in resource-rich countries are relatively trivial and transient with perhaps fever, malaise, myalgia, rash (exanthema) and sometimes mucosal manifestations (enanthema), including oral in some. However, the apparent benignity may be illusory as some viral infections have unexpected con...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12356

    authors: Scully C,Samaranayake LP

    更新日期:2016-04-01 00:00:00

  • Prevalence of oral disease among adults with primary HIV infection.

    abstract:OBJECTIVE:To explore the type and prevalence of oral mucosal lesions among adults with primary HIV infection (PHI) compared with HIV-negative adults at high risk for HIV disease, and in relation to HIV viral load. METHODS:We conducted standardized oral examinations to identify specific oral mucosal lesions among adult...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01407.x

    authors: Owotade FJ,Shiboski CH,Poole L,Ramstead CA,Malvin K,Hecht FM,Greenspan JS

    更新日期:2008-09-01 00:00:00

  • Autophagy inhibits TLR4-mediated invasiveness of oral cancer cells via the NF-κB pathway.

    abstract:OBJECTIVES:Toll-like receptor 4 (TLR4) is abnormally expressed in oral cancer tissues and promotes cancer cell invasion. The purpose of this study was to clarify the mechanism by which autophagy regulates oral cancer invasion through the TLR4-NF-κB pathway. SUBJECTS AND METHODS:We examined TLR4 expression in oral canc...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13355

    authors: Kong Q,Liang Y,He Q,You Y,Wu L,Liang L,Liang J

    更新日期:2020-04-14 00:00:00

  • Prevalence and classification of HIV-associated oral lesions.

    abstract:OBJECTIVES:An International Workshop addressed the prevalence and classification of HIV/ AIDS associated oral lesions. DESIGN:Five questions provided the framework for discussion and literature review. What is the prevalence of oral lesions in children and adults? Should the accepted classification of HIV-related oral...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1034/j.1601-0825.2002.00020.x

    authors: Patton LL,Phelan JA,Ramos-Gomez FJ,Nittayananta W,Shiboski CH,Mbuguye TL

    更新日期:2002-01-01 00:00:00

  • BRAF V600E expression in ameloblastomas-A 36-patient cohort from Helsinki University Hospital.

    abstract:OBJECTIVES:We aimed to investigate BRAF V600E percentage immunohistochemically in ameloblastomas of a single institute cohort. We were interested if age, location, histological properties, or tumor recurrence depend on the BRAF status. SUBJECTS, MATERIALS AND METHODS:We had 36 formalin-fixed, paraffin-embedded amelobl...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13072

    authors: Kelppe J,Thorén H,Ristimäki A,Haglund C,Sorsa T,Hagström J

    更新日期:2019-05-01 00:00:00