Immunohistochemical correlation between microvessel density and lymphoid infiltrate in radicular cysts.

Abstract:

OBJECTIVE:Radicular cysts occur as a result of the immunological response to continuous antigenic stimulation from root canals. We correlated the immunophenotypical composition of the lymphoid infiltrate to the microvessel density expressed by the count of CD34 reactive endothelial cells in radicular cysts. SUBJECTS AND METHODS:Thirty-four cases of radicular cysts were evaluated by immunohistochemistry, using antibodies against B- and T-cell antigens (CD20, CD3, CD4, CD8) and against the endothelial cell marker CD34. Statistical analysis was performed. RESULTS:In the epithelium, we observed a low amount of lymphoid infiltrate in all 34 radicular cysts, and a strong significant negative correlation between T and B lymphocytes and between T-helper and T-cytotoxic/suppressor lymphocytes. In the cyst capsule, we observed a significant positive correlation between B and T lymphocytes, B and T-cytotoxic/suppressor lymphocytes, T and T-helper lymphocytes and between the number of CD34+ blood vessels and T and T-helper lymphocytes, respectively. We observed a statistically significant correlation between percentage of CD34+ vessels and inflammatory infiltrate grade. CONCLUSIONS:Both humoral and cellular immune reactions and neovascularization are likely to occur in the complex events of tissue destruction. The inflammatory infiltrate has an important role in neoangiogenesis and consequently in radicular cysts development and growth.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Zizzi A,Aspriello SD,Ferrante L,Stramazzotti D,Colella G,Balercia P,Lo Muzio L,Piemontese M,Goteri G,Rubini C

doi

10.1111/j.1601-0825.2012.01961.x

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

92-9

issue

1

eissn

1354-523X

issn

1601-0825

journal_volume

19

pub_type

杂志文章
  • Oral lichen planus: a preliminary clinical study on treatment with tazarotene.

    abstract:OBJECTIVE:The rationale for using tazarotene in oral lichen planus (OLP) is its regulatory action on the growth and differentiation of keratinocytes and on inflammation. This randomized, placebo-controlled study addresses evaluation of the effects of topic tazarotene in the treatment of OLP. DESIGN:The degree of lesio...

    journal_title:Oral diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1601-0825.2002.02833.x

    authors: Petruzzi M,De Benedittis M,Grassi R,Cassano N,Vena G,Serpico R

    更新日期:2002-11-01 00:00:00

  • Oral complication risks after invasive and non-invasive dental procedures in HIV-positive patients.

    abstract:BACKGROUND:Limited published scientific evidence is available to provide guidance to clinicians on possible increased risks of invasive oral procedures associated with the human immunodeficiency virus (HIV) status of the patient. The aim of this study was to assess post-procedural complications in patients infected wit...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01262.x

    authors: Campo J,Cano J,del Romero J,Hernando V,Rodríguez C,Bascones A

    更新日期:2007-01-01 00:00:00

  • Rechargeable anticandidal denture material with sustained release in saliva.

    abstract:OBJECTIVE:Candida-induced denture stomatitis is a common debilitating problem among denture wearers. Previously, we described the fabrication of a new denture material that released antifungal drugs when immersed in phosphate buffered saline. Here, we use more clinically relevant immersion conditions (human saliva; 37°...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12456

    authors: Malakhov A,Wen J,Zhang BX,Wang H,Geng H,Chen XD,Sun Y,Yeh CK

    更新日期:2016-07-01 00:00:00

  • Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.

    abstract:OBJECTIVE:Transforming growth factor-beta (TGF-β) proteins are involved in epithelial keratinization. The major function of latent TGF-β binding proteins (LTBPs) is modulating TGF-β activity. However, whether LTBP-1 and LTBP-2 play roles in gingiva keratinization remains unclear. MATERIALS AND METHODS:Human keratinize...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12344

    authors: Chiang MS,Yang JR,Liao SC,Hsu CC,Hsu CW,Yuan K

    更新日期:2015-09-01 00:00:00

  • Poor patient compliance with instructions for continuous sialogogues after 131 I therapy.

    abstract:OBJECTIVES:To analyze the role of patient compliance as a factor in evaluating the effectiveness of continuous sialogogues to prevent salivary side effects from 131 I therapy in differentiated thyroid cancer patients. METHODS:Differentiated thyroid cancer patients who were clinically scheduled for an 131 I therapy at ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12969

    authors: Wu D,Khorjekar G,Kharazi P,Moreau S,Kulkarni K,Burman KD,Wartofsky L,Van Nostrand D

    更新日期:2019-01-01 00:00:00

  • Metastatic salivary gland carcinoma: A role for stereotactic body radiation therapy? A study of AIRO-Head and Neck working group.

    abstract:OBJECTIVES:The role of radiotherapy (RT) for oligometastases is currently established in different oncological settings but data on salivary gland cancer (SGC) are lacking. We evaluated the role of RT in oligometastatic SGC patients, focusing on stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS:We perf...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13755

    authors: Franzese C,Ingargiola R,Tomatis S,Iacovelli NA,Beltramo G,Franco P,Bonomo P,Zanetti IB,Argenone A,Cante D,Romanello DA,Musio D,De Felice F,Furlan C,Scorsetti M,Orlandi E

    更新日期:2020-12-15 00:00:00

  • Comparative effects of various commercially available mouthrinse formulations on oral malodor.

    abstract:OBJECTIVES:The primary aim of this study was to compare a new mouthwash (SB12®) containing 0.025% chlorhexidine and 0.3% zinc for oral malodor reduction against four commercially available mouthwashes and negative control. A secondary aim was to compare the two methods for measuring volatile sulphur compounds (VSC) by ...

    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.2010.01714.x

    authors: Saad S,Greenman J,Shaw H

    更新日期:2011-03-01 00:00:00

  • Osteoclast activation in inflammatory periodontal diseases.

    abstract:OBJECTIVE:In this paper, we review the mechanisms thought to be involved in the activation of osteoclasts in periodontitis. SUMMARY:Osteoclasts are regulated by both microbial and host factors. Some factors act directly on cells of the osteoclast lineage, whereas others act indirectly through other cell types in the b...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1996.tb00218.x

    authors: Wiebe SH,Hafezi M,Sandhu HS,Sims SM,Dixon SJ

    更新日期:1996-06-01 00:00:00

  • Periodontitis and respiratory diseases: A systematic review with meta-analysis.

    abstract:OBJECTIVE:To conduct a systematic review and meta-analysis to evaluate the recent scientific literature addressing the association between periodontitis and asthma, chronic obstructive pulmonary disease (COPD), and pneumonia. MATERIALS AND METHODS:The search for studies was carried out using MEDLINE/PubMed, EMBASE, Li...

    journal_title:Oral diseases

    pub_type: 杂志文章,meta分析

    doi:10.1111/odi.13228

    authors: Gomes-Filho IS,Cruz SSD,Trindade SC,Passos-Soares JS,Carvalho-Filho PC,Figueiredo ACMG,Lyrio AO,Hintz AM,Pereira MG,Scannapieco F

    更新日期:2020-03-01 00:00:00

  • Oral bacterial diversity is inversely correlated with mucosal inflammation.

    abstract:OBJECTIVE:We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP). METHODS:Patients with RAS (n = 15) and LP (n = 18) an...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13420

    authors: Hijazi K,Morrison RW,Mukhopadhya I,Martin B,Gemmell M,Shaw S,Santoro F

    更新日期:2020-10-01 00:00:00

  • HIV infection and periodontal diseases: an overview of the post-HAART era.

    abstract::HIV infection remains a global health problem of unprecedented dimensions, although the development of highly active antiretroviral therapy (HAART) has significantly modified the course of HIV disease into a manageable chronic disease with longer survival and improved quality of life in HIV-infected subjects. Among th...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01727.x

    authors: Mataftsi M,Skoura L,Sakellari D

    更新日期:2011-01-01 00:00:00

  • Betel and tobacco chewing habit and its relation to risk factors for periodontal disease.

    abstract:OBJECTIVES:To comparatively assess periodontal status in patients who chew different products and patients who do not have this habit and to assess how this practice interacts with predisposing factors and risk indicators of disease. METHODS:Patients included in the dental care carried out in a rural community in Indi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12820

    authors: Giovannoni ML,Valdivia-Gandur I,Lozano de Luaces V,Varela Véliz H,Balasubbaiah Y,Chimenos-Küstner E

    更新日期:2018-07-01 00:00:00

  • Traditional Chinese medicine and oral diseases: today and tomorrow.

    abstract::With a history of over 2000 years, traditional Chinese medicine (TCM) evolves into a unique system of diagnosing and treating illnesses. It is a challenge to convey the fundamentals of this traditional medicine to our Western colleagues because of the differences in language, philosophy and concept of diagnosis and tr...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01706.x

    authors: Zheng LW,Hua H,Cheung LK

    更新日期:2011-01-01 00:00:00

  • Locally delivered antimicrobials for the treatment of chronic periodontitis.

    abstract::The basic treatment of chronic periodontitis is a mechanical debridement of periodontal pockets by scaling and root planing (S/RP) in combination with efficient plaque control. Locally delivered antiseptics (LDA) have been proposed to practitioners and, while subgingival irrigation of antiseptics is still used in clin...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1034/j.1601-0825.9.s1.8.x

    authors: Etienne D

    更新日期:2003-01-01 00:00:00

  • The familial trend of the local inflammatory response in periodontal disease.

    abstract:OBJECTIVES:The imbalanced host response in front of a dysbiotic biofilm is one of the major aspects of severe periodontitis, which also presents a strong familial aggregation related to the susceptibility factors transmission within family members. This study hypothesized that aggressive periodontitis (GAgP) patients a...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13738

    authors: Monteiro MF,Casati MZ,Sallum EA,Silvério KG,Nociti-Jr FH,Casarin RCV

    更新日期:2020-11-30 00:00:00

  • Pharmacodiagnostic evaluation of EGFR expression in oral squamous cell carcinoma.

    abstract:OBJECTIVE:To determine epidermal growth factor receptor (EGFR) expression in oral squamous cell carcinomas (OSCC), and its possible relationships with clinical findings, histological findings, disease course and prognosis. MATERIALS AND METHODS:Surgical specimens of 47 OSCCs were studied immunohistochemically for dete...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01280.x

    authors: Diniz-Freitas M,García-Caballero T,Antúnez-López J,Gándara-Rey JM,García-García A

    更新日期:2007-05-01 00:00:00

  • A nomogram for predicting the risk of neck node metastasis in pathologically node-negative oral cavity carcinoma.

    abstract:OBJECTIVE:To generate a nomogram for predicting the risk of neck node metastasis in pathologically node-negative patients using a combination of variables comprising of protein expression, ultrastructural alterations and clinicopathological parameters. MATERIALS AND METHODS:Surgically removed oral tumours (n = 103) we...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12696

    authors: Sawant SS,Dongre H,Ahire C,Sharma S,Kannan S,Mahadik S,Chaukar D,Lukmani F,Patil A,D'Cruz A,Vaidya MM,Dongre P

    更新日期:2017-11-01 00:00:00

  • Relationship between periodontal disease and male infertility: A case-control study.

    abstract:OBJECTIVES:To compare the prevalence of chronic periodontitis between men who had semen abnormalities and those who had normozoospermia through a case-control study. MATERIALS AND METHODS:Male patients who visited the assisted reproduction clinic of a large general hospital and were diagnosed with semen abnormalities ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13552

    authors: Tao DY,Zhu JL,Xie CY,Kuang YP,Chai WR,Lo ECM,Ye W,Li F,Feng XP,Lu HX

    更新日期:2020-07-23 00:00:00

  • Granzyme B-truncated VEGF fusion protein represses angiogenesis and tumor growth of OSCC.

    abstract:OBJECTIVE:To evaluate the antitumor effects of fusion protein hGrB-TV of human granzyme B (hGrB) and truncated vascular endothelial growth factor (tVEGF) on human oral squamous cell carcinoma (OSCC) in vitro and in vivo. METHODS:The fusion protein hGrB-TV was expressed and purified from E. coli bacteria by affinity ch...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12522

    authors: Lv XZ,Zheng MY,Lin ZQ,Zhao M,Wang H,Zeng WS

    更新日期:2016-10-01 00:00:00

  • Micronuclear and sister chromatid exchange analyses in peripheral lymphocytes of patients with oral lichen planus--a pilot study.

    abstract:OBJECTIVE:The purpose of this study was to determine the genetic instability of peripheral blood lymphocytes from patients diagnosed with oral lichen planus (OLP) by investigation of frequencies of micronuclei (MN) and sister chromatid exchange (SCE). MATERIALS AND METHODS:A total of 22 newly diagnosed and untreated p...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01576.x

    authors: Ergun S,Warnakulasuriya S,Duman N,Saruhanoğlu A,Sevinç B,Oztürk S,Ozel S,Cefle K,Palanduz S,Tanyeri H

    更新日期:2009-10-01 00:00:00

  • Effect of HAART on salivary gland function in the Women's Interagency HIV Study (WIHS).

    abstract:OBJECTIVE:To determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in human immunodeficiency virus (HIV) positive women from the Women's Interagency HIV Study (WIHS). DESIGN:Longitudinal cohort study. SUBJECTS AND METHODS:A total of 668 HIV positive women from the WIHS cohort...

    journal_title:Oral diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1601-0825.2008.01456.x

    authors: Navazesh M,Mulligan R,Karim R,Mack WJ,Ram S,Seirawan H,Greenspan J,Greenspan D,Phelan J,Alves M,Oral Substudy of the Women's Interagency HIV Study Collaborative Study Group*.

    更新日期:2009-01-01 00:00:00

  • Cytokeratins in epithelia of odontogenic neoplasms.

    abstract::Neoplasms and tumours related to the odontogenic apparatus may be composed only of epithelial tissue or epithelial tissue associated with odontogenic ectomesenchyme. The immunohistochemical detection of different cytokeratins (CKs) polypeptides and vimentin has made it easier to explain the histogenesis of many epithe...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2003.00861.x

    authors: Crivelini MM,de Araújo VC,de Sousa SO,de Araújo NS

    更新日期:2003-01-01 00:00:00

  • Whole-genome sequencing in a pair of monozygotic twins with discordant cleft lip and palate subtypes.

    abstract:OBJECTIVE:Orofacial clefts (OFCs) are common and etiologically complex birth defects. This study explored potential genetic differences in a pair of Japanese monozygotic (MZ) twins with different forms of OFC using whole-genome sequencing. SUBJECTS AND METHODS:One co-twin (MZ-1) presented with nonsyndromic bilateral c...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12910

    authors: Takahashi M,Hosomichi K,Yamaguchi T,Nagahama R,Yoshida H,Maki K,Marazita ML,Weinberg SM,Tajima A

    更新日期:2018-10-01 00:00:00

  • Practices of Maryland dentists: oral cancer prevention and early detection--baseline data from 1995.

    abstract:OBJECTIVES:To investigate practices and opinions of general dentists in Maryland, USA, related to oral and pharyngeal cancer prevention and early detection. DESIGN AND METHODS:A pre-tested, 34-item questionnaire, cover letter and addressed, stamped envelope were mailed in the summer, 1995, to a simple random sample of...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2000.tb00140.x

    authors: Horowitz AM,Drury TF,Canto MT

    更新日期:2000-09-01 00:00:00

  • Involvement of transient receptor potential vanilloid 2 in intra-oral incisional pain.

    abstract:OBJECTIVE:To examine whether transient receptor potential vanilloid 2 (TRPV2) contributes to the changes in intra-oral thermal and mechanical sensitivity following the incision of buccal mucosa. MATERIALS AND METHODS:Buccal mucosal pain threshold was measured after the incision. Changes in the number of TRPV2-immunore...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12853

    authors: Urata K,Shinoda M,Ikutame D,Iinuma T,Iwata K

    更新日期:2018-09-01 00:00:00

  • Collagenases and tissue inhibitors of metalloproteinases: a functional balance in tissue degradation.

    abstract:BACKGROUND:Members of the family of matrix metalloproteinases (MMPs; also called collagenases or matrixins) are key enzymes in matrix degradation. They function at neutral pH and can digest synergistically all the matrix macromolecules. Biochemical and clonal studies indicate that there are three major groups: the spec...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1996.tb00206.x

    authors: Reynolds JJ

    更新日期:1996-03-01 00:00:00

  • The paradox of painless periodontal disease.

    abstract::Periodontal diseases, primarily gingivitis and periodontitis, are characterised by progressive inflammation and tissue destruction. However, they are unusual in that they are not also accompanied by the pain commonly seen in other inflammatory conditions. This suggests that interactions between periodontal bacteria an...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12537

    authors: Gaurilcikaite E,Renton T,Grant AD

    更新日期:2017-05-01 00:00:00

  • Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption.

    abstract:OBJECTIVE:Orthodontic-induced external apical root resorption (EARR) is a complex phenotype determined by poorly defined mechanical and patient intrinsic factors. The aim of this work was to construct a multifactorial integrative model, including clinical and genetic susceptibility factors, to analyze the risk of devel...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12185

    authors: Pereira S,Lavado N,Nogueira L,Lopez M,Abreu J,Silva H

    更新日期:2014-10-01 00:00:00

  • Necroptosis in the periodontal homeostasis: Signals emanating from dying cells.

    abstract::Periodontal tissues are constantly exposed to microbial stimuli. The equilibrium between microbes and host defense system helps maintain the homeostasis in the periodontal microenvironment. Growth of pathogenic bacteria in dental biofilms may induce proinflammatory cytokine production to recruit sentinel cells, mainly...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12722

    authors: Li J,Ke X,Yan F,Lei L,Li H

    更新日期:2018-09-01 00:00:00

  • Bifunctional anticaries peptides with antibacterial and remineralizing effects.

    abstract:OBJECTIVES:Initial dental caries often occurs in clinic. Reduction of cariogenic bacteria and promotion of remineralization are effective ways to control them. This study was to develop bifunctional anticaries peptides with antibacterial and remineralizing properties. METHODS:We designed peptides TDH19, TNH19, and TVH...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12990

    authors: Wang X,Wang Y,Wang K,Ren Q,Li H,Zheng S,Niu Y,Zhou X,Li W,Zhang L

    更新日期:2019-03-01 00:00:00