Abstract:
OBJECTIVE:To determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in human immunodeficiency virus (HIV) positive women from the Women's Interagency HIV Study (WIHS). DESIGN:Longitudinal cohort study. SUBJECTS AND METHODS:A total of 668 HIV positive women from the WIHS cohort with an initial and at least one follow-up oral sub-study visit contributed 5358 visits. Salivary gland function was assessed based on a dry mouth questionnaire, whole unstimulated and stimulated salivary flow rates, salivary gland enlargement or tenderness and lack of saliva on palpation of the major salivary glands. MAIN OUTCOME MEASURES:Changes in unstimulated and stimulated flow rates at any given visit from that of the immediate prior visit (continuous variables). The development of self-reported dry mouth (present/absent), enlargement or tenderness of salivary glands (present/absent), and absence of secretion on palpation of the salivary glands were binary outcomes (yes/no). RESULTS:Protease Inhibitor (PI) based HAART was a significant risk factor for developing decreased unstimulated (P = 0.01) and stimulated (P = 0.0004) salivary flow rates as well as salivary gland enlargement (P = 0.006) as compared with non-PI based HAART. CONCLUSIONS:PI-based HAART therapy is a significant risk factor for developing reduced salivary flow rates and salivary gland enlargement in HIV positive patients.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Navazesh M,Mulligan R,Karim R,Mack WJ,Ram S,Seirawan H,Greenspan J,Greenspan D,Phelan J,Alves M,Oral Substudy of the Women's Interagency HIV Study Collaborative Study Group*.doi
10.1111/j.1601-0825.2008.01456.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
52-60issue
1eissn
1354-523Xissn
1601-0825pii
ODI1456journal_volume
15pub_type
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