The use of tretinoin as oral mucositis prophylaxis in bone marrow transplantation patients: a preliminary study.

Abstract:

OBJECTIVE:The examination of prophylactic efficacy of tretinoin on oral mucositis, post bone marrow transplantation (BMT). PATIENTS AND METHODS:The study population consisted of 11 patients undergoing BMT. Six tretinoin topically-treated patients (0.25 mg daily of 0.1% tretinoin cream) were matched with five non-treated control patients comparing mucositis severity, duration and analgetic (morphine) requirements. Concomitant follow-up included conditioning parameters associated with mucositis and engraftment. RESULTS:The mean of oral mucositis peak scores was significantly lower in the tretinoin-treated patients vs the non-treated patients (score 1.5 vs 3.6; P < 0.02). In the majority of cases the duration of the most severe phase of oral mucositis was shorter in the tretinoin-treated group as compared with the control. Only one patient in the experimental group required morphine analgesics compared with four patients in the control group. CONCLUSIONS:This preliminary study indicates that the severity of oral mucositis, both objective and subjective, in BMT patients may be reduced by 0.1% topical tretinoin cream, 0.25 mg, administered daily from the beginning of the BMT conditioning regimen until marrow engraftment.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Cohen G,Elad S,Or R,Galili D,Garfunkel AA

doi

10.1111/j.1601-0825.1997.tb00049.x

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

243-6

issue

4

eissn

1354-523X

issn

1601-0825

journal_volume

3

pub_type

临床试验,杂志文章,随机对照试验
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