Nitric oxide synthesis and severity of human periodontal disease.

Abstract:

UNLABELLED:The expression of the inducible nitric oxide synthase enzyme (iNOS) is a response to an inflammatory stimulus and produces a large amount of nitric oxide (NO), which may act as a cytotoxic molecule against the invading microorganism and may be related to both harmful and beneficial effects to tissues. OBJECTIVE AND MATERIAL AND METHODS:In order to further characterize the presence of NO in human periodontal disease, we undertook a quantitative study of iNOS positive cells in samples of clinically healthy gingival tissues, plaque-induced gingivitis and localized chronic periodontitis using immunohistochemistry. RESULTS:A significant increase in the number of iNOS+ cells mm-2 was found in the samples of the gingivitis and periodontitis compared with those of the control. In all groups most of the polymorphonuclear cells showed intense immunoreactivity for iNOS independent of the disease stage, and the percentage of iNOS+ polymorphonuclear cells increased significantly in periodontal disease when compared with the control. CONCLUSION:Our results indicate that iNOS increases in the presence of periodontal disease. In addition, our findings suggest that polymorphonuclear cells present an additional activation pathway in periodontal disease, expressing significant iNOS and probably representing an important source of NO in human periodontal disease that has not been previously reported.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Batista AC,Silva TA,Chun JH,Lara VS

doi

10.1034/j.1601-0825.2002.02852.x

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

254-60

issue

5

eissn

1354-523X

issn

1601-0825

journal_volume

8

pub_type

杂志文章
  • The impact of the world Workshops on oral health and disease in HIV and AIDS (1988-2020).

    abstract::The first World Workshop on Oral AIDS was held in San Diego in 1988, organized by John and Deborah Greenspan who saw the need and advantages of getting together all those health workers globally who were interested in oral aspects of HIV with a common purpose of advancing the field collectively and collaboratively. Si...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13385

    authors: Greenspan JS,Challacombe SJ

    更新日期:2020-09-01 00:00:00

  • Poland-Moebius syndrome: a case with oral anomalies.

    abstract::The combination of Moebius and Poland anomalies is rarely described in the literature. While some authors believe this association is an independent syndrome, others think that Poland, Moebius and Poland-Moebius syndromes are variations of the same condition. We report a case of Poland-Moebius syndrome in a 6-year-old...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2004.01045.x

    authors: Domingos AC,Lopes SL,Almeida SM,Boscolo FN,Whaites EJ

    更新日期:2004-11-01 00:00:00

  • Oral health of patients with hepatitis C virus infection: a pilot study.

    abstract:OBJECTIVES:This study examined the oral health of a cohort of hepatitis C virus (HCV) patients. In particular, the prevalence of lichen planus and xerostomia were determined. Experiences of discrimination against HCV-infected patients by their dentists were also recorded. METHODS:Forty patients infected with HCV, who ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2001.00695.x

    authors: Henderson L,Muir M,Mills PR,Spence E,Fox R,McCruden EA,Bagg J

    更新日期:2001-09-01 00:00:00

  • The heme oxygenase system and oral diseases.

    abstract::Oral Diseases (2011) 17, 252-257 Heme oxygenase (HO) system catabolizes heme into three products: carbon monoxide (CO), biliverdin/bilirubin and free iron, which consists of three forms identified to date: the oxidative stress-inducible protein HO-1 and the constitutive isozymes HO-2 and HO-3. HO has been involved in ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01732.x

    authors: Fan W,Huang F,Zhu X,Li D,Fu S,He H

    更新日期:2011-04-01 00:00:00

  • Chemokines and chemokine receptors: the key to understanding AIDS.

    abstract::This article reviews the recent rapid developments in research that have demonstrated the importance of chemokines and their receptors in HIV infection and the progression to AIDS. These discoveries have transformed our understanding of how the virus may infect cells and why certain individuals may be resistant to HIV...

    journal_title:Oral diseases

    pub_type: 社论,评审

    doi:10.1111/j.1601-0825.1997.tb00002.x

    authors: Thornhill MH,Li J

    更新日期:1997-03-01 00:00:00

  • Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.

    abstract::Despite the presence of HIV-1 in the oral cavity, transmission of the virus through saliva has not been proven. Consistent with these observations, we recently identified an endogenous 12 kD protein, secretory leukocyte protease inhibitor (SLPI), in saliva which blocks HIV-1 infection in vitro. Whereas other salivary ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1997.tb00377.x

    authors: Wahl SM,McNeely TB,Janoff EN,Shugars D,Worley P,Tucker C,Orenstein JM

    更新日期:1997-05-01 00:00:00

  • Role of oral examination in newly diagnosed multiple myeloma patients: A safe and simple way to detect light chain amyloidosis.

    abstract:OBJECTIVE:Up to 30% of multiple myeloma (MM) patients have subclinical amyloid deposits. These patients are under-recognized and are more susceptible to drug toxicity, bleeding and death. Early diagnosis and adjustment of treatment are crucial. Biopsies of oral mucosa might be a potentially useful diagnostic tool. The ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12901

    authors: Leiba M,Jarjoura S,Abboud W,Nagler A,Yahalom R,Duek A,Yarom N

    更新日期:2018-10-01 00:00:00

  • MicroRNA-21 promotes orthodontic tooth movement by modulating the RANKL/OPG balance in T cells.

    abstract:OBJECTIVES:The present study was designed to investigate the effects of microRNA-21 (miR-21) on orthodontic tooth movement. METHODS:The orthodontic tooth movement model was established in C57BL/6 and miR-21-/- mice with or without implantation of activated T cells. Histological and histomorphometrical analyses were pe...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13239

    authors: Wu L,Su Y,Lin F,Zhu S,Wang J,Hou Y,Du J,Liu Y,Guo L

    更新日期:2020-03-01 00:00:00

  • Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature.

    abstract:OBJECTIVE:Rheumatoid arthritis (RA) and periodontitis share several pathological features including bone and soft tissue destruction and high levels of circulating inflammatory proteins. Studies related to cytokines in the periodontal inflammatory exudate (gingivocrevicular fluid, GCF) of RA patients might provide insi...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13145

    authors: Rahajoe PS,Smit MJ,Kertia N,Westra J,Vissink A

    更新日期:2019-09-01 00:00:00

  • Elder neglect-Oral diseases and injuries.

    abstract::Elder neglect (EN) is the failure of a designated caregiver to meet the needs of a dependent older person. World EN prevalence, meta-analyzed in this study, is 1.0% or 1.8% according to different statistical methods. Referring alleged EN cases to Adult Protective Services (APSs) by healthcare workers (HCWs) is mandato...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12797

    authors: Petti S

    更新日期:2018-09-01 00:00:00

  • TNF as marker of oral candidiasis, HSV infection, and mucositis onset during chemotherapy in leukemia patients.

    abstract:OBJECTIVE:To assess changes in the salivary expression of IL-1α, IL-1β, IL-2, IL-6, IL-10, IL-17, and TNF in acute leukemia (AL) patients before and during chemotherapy, and its association with HSV infection, oral candidiasis (OC), and oral mucositis (OM) onset. METHODS:Cohort study in AL patients >15 years starting ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12677

    authors: Ramírez-Amador V,Zambrano JG,Anaya-Saavedra G,Zentella-Dehesa A,Irigoyen-Camacho E,Meráz-Cruz N,Ponce de León-Rosales S

    更新日期:2017-10-01 00:00:00

  • Fourier Transform Infrared Imaging analysis of dental pulp inflammatory diseases.

    abstract:OBJECTIVES:Fourier Transform Infrared microspectroscopy let characterize the macromolecular composition and distribution of tissues and cells, by studying the interaction between infrared radiation and matter. Therefore, we hypothesize to exploit this analytical tool in the analysis of inflamed pulps, to detect the dif...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12635

    authors: Giorgini E,Sabbatini S,Conti C,Rubini C,Rocchetti R,Fioroni M,Memè L,Orilisi G

    更新日期:2017-05-01 00:00:00

  • Effect of aluminum concentration on dental caries formation in the rat.

    abstract:OBJECTIVE:Topically applied aluminum (AI) reduced fissure caries in rats with indigenous microflora, but neither therapeutic activity nor concentration effects have been studied in animals infected with caries-inducing bacteria. This study investigated the effects of solutions containing various AI concentrations on fo...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1995.tb00164.x

    authors: Putt MS,Kleber CJ

    更新日期:1995-06-01 00:00:00

  • Hyaline ring granuloma of the mouth-A foreign-body reaction that dentists should be aware of: Critical review of literature and histochemical/immunohistochemical study of a new case.

    abstract::Hyaline ring granuloma (HRG) is a rare and atypical foreign-body granulomatous chronic inflammatory condition. Our aim was to make a critical review of the literature cases and also to illustrate histochemical and immunohistochemical findings of a new case. A modified PICO strategy was used. Inclusion criteria were me...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13287

    authors: Kimura TC,Carneiro MC,Coelho YFS,de Sousa SCOM,Veltrini VC

    更新日期:2020-01-24 00:00:00

  • The paradox of painless periodontal disease.

    abstract::Periodontal diseases, primarily gingivitis and periodontitis, are characterised by progressive inflammation and tissue destruction. However, they are unusual in that they are not also accompanied by the pain commonly seen in other inflammatory conditions. This suggests that interactions between periodontal bacteria an...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12537

    authors: Gaurilcikaite E,Renton T,Grant AD

    更新日期:2017-05-01 00:00:00

  • Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer.

    abstract:OBJECTIVE:To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. SUBJECTS AND METHODS:INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a lar...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13502

    authors: Bravi F,Lee YA,Hashibe M,Boffetta P,Conway DI,Ferraroni M,La Vecchia C,Edefonti V,INHANCE Consortium investigators.

    更新日期:2021-01-01 00:00:00

  • Borate bioactive glass prevents zoledronate-induced osteonecrosis of the jaw by restoring osteogenesis and angiogenesis.

    abstract:OBJECTIVES:Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe complication of systemic nitrogen-containing bisphosphonate (N-BP) administration, which leads to osteonecrosis, pain, and infection. Despite much effort, effective remedies are yet to be established. This study aimed to investigate potentia...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13436

    authors: Su Z,Li J,Bai X,Tay FR,Zhang M,Liang K,He L,Yuan H,Li J

    更新日期:2020-11-01 00:00:00

  • Saliva with reduced calcium and phosphorous concentrations: Effect on erosion dental lesions.

    abstract:OBJECTIVES:To investigate whether saliva formulations with reduced calcium (Ca) and inorganic phosphorous (Pi) concentration would affect dental erosion caused by hydrochloric acid (HCl). METHODS:Enamel and root dentine bovine slabs were embedded, polished, and measured for surface Knoop microhardness (SMH). After ref...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12843

    authors: Denucci GC,Mantilla TF,Amaral F,Basting RT,França F,Turssi CP

    更新日期:2018-09-01 00:00:00

  • Cathepsin K modulates invasion, migration and adhesion of oral squamous cell carcinomas in vitro.

    abstract:OBJECTIVE:Cathepsin K was initially discovered as an osteoclast-specific cysteine proteinase, but the enzyme is also expressed in various cancers including oral squamous cell carcinomas. This study aimed to clarify the function of cathepsin K in oral squamous cell carcinomas. MATERIALS AND METHODS:Expression levels of...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12643

    authors: Yamashita K,Iwatake M,Okamoto K,Yamada SI,Umeda M,Tsukuba T

    更新日期:2017-05-01 00:00:00

  • Peripheral painful traumatic trigeminal neuropathies.

    abstract::The aim of this article is to review the clinical, pathophysiological, and therapeutic aspects of traumatically induced trigeminal nerve pain. We introduce a new and, in our view, more accurate terminology: peripheral painful traumatic trigeminal neuropathy (PPTTN) to define this patient group. The proposed pathophysi...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2011.01883.x

    authors: Benoliel R,Kahn J,Eliav E

    更新日期:2012-05-01 00:00:00

  • Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome.

    abstract:OBJECTIVE:Patients with burning mouth syndrome (BMS) often represent a clinical challenge as available agents for symptomatic treatment are few and often ineffective. The aim was to evaluate the effect of a bupivacaine lozenge on oral mucosal pain, xerostomia, and taste alterations in patients with BMS. METHODS:Eighte...

    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/odi.12386

    authors: Treldal C,Jacobsen CB,Mogensen S,Rasmussen M,Jacobsen J,Petersen J,Lynge Pedersen AM,Andersen O

    更新日期:2016-03-01 00:00:00

  • A multicenter study of oral sarcomas in Brazil.

    abstract:OBJECTIVES:The aim of this study was to investigate the prevalence of oral sarcomas from geographic regions of Brazil. MATERIALS AND METHODS:A cross-sectional study was conducted on biopsies obtained from January 2007 to December 2016 at twelve Brazilian oral and maxillofacial pathology centres. Gender, age, evolution...

    journal_title:Oral diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1111/odi.13211

    authors: de Carvalho WRS,de Souza LL,Pontes FSC,Uchôa DCC,Corrêa DL,de Cáceres CVBL,Lopes MA,Santos-Silva AR,Vargas PA,de Andrade BAB,Romañach M,Gomez RS,Costa SFDS,Batista AC,Mendonça EF,Pinto DDS Júnior,Gondak R,da Cruz Perez

    更新日期:2020-01-01 00:00:00

  • Micronuclear and sister chromatid exchange analyses in peripheral lymphocytes of patients with oral lichen planus--a pilot study.

    abstract:OBJECTIVE:The purpose of this study was to determine the genetic instability of peripheral blood lymphocytes from patients diagnosed with oral lichen planus (OLP) by investigation of frequencies of micronuclei (MN) and sister chromatid exchange (SCE). MATERIALS AND METHODS:A total of 22 newly diagnosed and untreated p...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01576.x

    authors: Ergun S,Warnakulasuriya S,Duman N,Saruhanoğlu A,Sevinç B,Oztürk S,Ozel S,Cefle K,Palanduz S,Tanyeri H

    更新日期:2009-10-01 00:00:00

  • The microbiome-systemic diseases connection.

    abstract::The human microbiome consists of all microorganisms occupying the skin, mucous membranes and intestinal tract of the human body. The contact of the mucosal immune system with the human microbiome is a balanced interplay between defence mechanisms of the immune system and symbiotic or pathogenic microbial factors, such...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12472

    authors: van der Meulen TA,Harmsen H,Bootsma H,Spijkervet F,Kroese F,Vissink A

    更新日期:2016-11-01 00:00:00

  • Novel rare variations in IRF6 in subjects with non-syndromic cleft lip and palate and dental agenesis.

    abstract:OBJECTIVE:Subjects with cleft lip and palate (CLP) present high prevalence of dental agenesis. Among candidate genes for these phenotypes is IRF6. However, genetic studies do not analyze dental agenesis as a phenotype associated with cleft. Therefore, we investigated the frequency of rare and novel variations in IRF6 i...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12975

    authors: Neves LT,Dionísio TJ,Garbieri TF,Parisi VA,Oliveira FV,Oliveira TM,Santos CF

    更新日期:2019-01-01 00:00:00

  • GSTM1 enzyme concentration and enzyme activity in correlation to the genotype of detoxification enzymes in squamous cell carcinoma of the oral cavity.

    abstract:BACKGROUND:Differences in genotype and phenotype of detoxification genes could be one reason for conflicting results in studies dealing with gene polymorphisms as susceptibility factors for tobacco associated cancer. OBJECTIVES:The objective of this study was to investigate gene polymorphisms of detoxification enzymes...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2003.02866.x

    authors: Gronau S,Koenig-Greger D,Jerg M,Riechelmann H

    更新日期:2003-03-01 00:00:00

  • Trigeminal autonomic cephalalgias.

    abstract::The trigeminal autonomic cephalalgias (TACs) are a group of primary headache disorders characterised by lateralized symptoms: prominent headache and ipsilateral cranial autonomic features, such as conjunctival injection, lacrimation and rhinorrhea. The TACs are: cluster headache (CH), paroxysmal hemicrania (PH), short...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12263

    authors: Eller M,Goadsby PJ

    更新日期:2016-01-01 00:00:00

  • Development of lung metastases in mouse models of tongue squamous cell carcinoma.

    abstract:OBJECTIVE:Oral squamous cell carcinoma (OSCC) represents 3%-4% of all cancers. Despite the increasing incidence of OSCC distant metastasis and poor prognosis, few animal models of OSCC distant metastasis have been reported. In this study, we established mouse models of OSCC lung metastasis by orthotopic and tail vein i...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13592

    authors: Marcazzan S,Dadbin A,Brachi G,Blanco E,Varoni EM,Lodi G,Ferrari M

    更新日期:2020-08-07 00:00:00

  • Rechargeable anticandidal denture material with sustained release in saliva.

    abstract:OBJECTIVE:Candida-induced denture stomatitis is a common debilitating problem among denture wearers. Previously, we described the fabrication of a new denture material that released antifungal drugs when immersed in phosphate buffered saline. Here, we use more clinically relevant immersion conditions (human saliva; 37°...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12456

    authors: Malakhov A,Wen J,Zhang BX,Wang H,Geng H,Chen XD,Sun Y,Yeh CK

    更新日期:2016-07-01 00:00:00

  • The homeobox HOXB13 is expressed in human minor salivary gland.

    abstract:BACKGROUND:Homeobox are a family of developmental genes involved in morphogenesis and cellular differentiation. Participation of homeobox within normal and malignant tissue has been recently discussed in the literature. OBJECTIVE:To analyze the presence of HOXB13 transcript expression in human minor salivary gland. M...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2005.01218.x

    authors: Cazal C,Sobral AP,de Almeida FC,das Graças Silva-Valenzuela M,Durazzo MD,Nunes FD

    更新日期:2006-07-01 00:00:00