Abstract:
BACKGROUND:Homeobox are a family of developmental genes involved in morphogenesis and cellular differentiation. Participation of homeobox within normal and malignant tissue has been recently discussed in the literature. OBJECTIVE:To analyze the presence of HOXB13 transcript expression in human minor salivary gland. MATERIAL AND METHODS:Ten-micrometer sections from frozen samples were evaluated employing non-radioactive in situ hybridization technique and HOXB13 mRNA probes. RESULTS:HOXB13 was found to be expressed in ducts and mucous acini but not in serous acini. CONCLUSIONS:RESULTS suggest that HOXB13 transcripts are differently expressed in normal mucous and serous acini, and it may possibly reflect a different role in salivary gland carcinogenesis.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Cazal C,Sobral AP,de Almeida FC,das Graças Silva-Valenzuela M,Durazzo MD,Nunes FDdoi
10.1111/j.1601-0825.2005.01218.xsubject
Has Abstractpub_date
2006-07-01 00:00:00pages
424-7issue
4eissn
1354-523Xissn
1601-0825pii
ODI1218journal_volume
12pub_type
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