Abstract:
BACKGROUND:Tumour budding (B) and depth of invasion (D) have both been reported as promising prognostic markers in oral squamous cell carcinoma (OSCC). This meta-analysis assessed the prognostic value of the tumour budding and depth of invasion combination (BD model) in OSCC. METHODS:Databases including Ovid MEDLINE, PubMed, Scopus and Web of Science were searched for articles that studied the BD model as a prognosticator in OSCC. PICO search strategy was "In OSCC patients, does BD model have a prognostic power?" We used the reporting recommendations for tumour marker prognostic studies (REMARK) criteria to evaluate the quality of studies eligible for systematic review and meta-analysis. RESULTS:Nine studies were relevant as they analysed the BD model for prognostication of OSCC. These studies used either haematoxylin and eosin (HE) or pan-cytokeratin (PCK)-stained resected sections of OSCC. Our meta-analysis showed a significant association of BD model with OSCC disease-free survival (hazard ratio = 2.02; 95% confidence interval = 1.44-2.85). CONCLUSIONS:The BD model is a simple and reliable prognostic indicator for OSCC. Evaluation of the BD model from HE- or PCK-stained sections could facilitate individualized treatment planning for OSCC patients.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Wahab A,Onkamo O,Pirinen M,Almangush A,Salo Tdoi
10.1111/odi.13671subject
Has Abstractpub_date
2020-10-08 00:00:00eissn
1354-523Xissn
1601-0825pub_type
杂志文章,评审相关文献
ORAL DISEASES文献大全abstract:OBJECTIVES:To determine glucose transporter 1 (GLUT1) and runt-related transcription factor 2 (RUNX2) expression during reparative dentinogenesis after pulpotomy with mineral trioxide aggregate (MTA) capping. SUBJECTS AND METHODS:Eight-week-old male Wistar rats were used. Pulp of the upper left first molar was exposed...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13230
更新日期:2020-03-01 00:00:00
abstract::Candidosis is by far the commonest oral fungal infection in man and could manifest as an adverse effect of drug therapy such as inhaled or topically applied corticosteroids. Due to the anti-inflammatory and immunosuppressive effect steroids are used in the management of bronchial asthma and oral mucosal diseases. In t...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:
更新日期:2001-07-01 00:00:00
abstract::Dental research over the last century has advanced our understanding of the etiology and pathogenesis of caries lesions. Increasing knowledge of the dynamic demineralization/remineralization processes has led to the current consensus that bacteria-mediated tooth destruction can be arrested or even to some degree rever...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2004.01030.x
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVES:Autosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI) shows phenotypic heterogeneity. Our aim was to characterise the ADHCAI phenotypes, tooth properties and genotypes. METHODS:Three unrelated ADHCAI probands and seven additional affected members of the three families were recruited. Mutations w...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13780
更新日期:2021-01-24 00:00:00
abstract:OBJECTIVE:To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction. METHODS:Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2004.01037.x
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:Lactobacilli are considered cariogenic micro-organisms. As oral species of lactobacilli have not been thoroughly described, the aim of this work was to isolated and identify these organisms from teeth, tongue, saliva and gum of healthy patients and to describe some of their surface properties. SUBJECTS:Forty...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2000.tb00118.x
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To document the pattern of intra-oral carcinomas diagnosed in north-eastern Nigeria. DESIGN AND SETTING:A retrospective clinical and histopathological review seen in a tertiary care hospital (January 1987-December 2002). MATERIALS AND METHODS:Information on socio-demographic characteristics of patients and ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2005.01134.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:Cyclosporine A (CsA) is used as an immunosuppressive agent and its prominent side effect is the induction of gingival overgrowth. Type I plasminogen activator inhibitor (PAI-1) has shown to play an important role in CsA-induced gingival overgrowth. However, little is known about whether factors can modulate ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01653.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:In this paper, we review the mechanisms thought to be involved in the activation of osteoclasts in periodontitis. SUMMARY:Osteoclasts are regulated by both microbial and host factors. Some factors act directly on cells of the osteoclast lineage, whereas others act indirectly through other cell types in the b...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.1996.tb00218.x
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:To investigate a possible role of adiponectin in the pathogenesis of autoimmune sialoadenitis in non-obese diabetic (NOD) mouse model of Sjögren's syndrome. MATERIALS AND METHODS:Expression of adiponectin and its receptors (AdipoR1/2) was detected by PCR, immunoblotting, or immunofluorescence. The level of a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12197
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To establish whether an intra-oral lubricating device for dry mouth alters the oral environment. DESIGN:A single-blind randomized cross-over study. METHOD:Twenty-nine dentate subjects from the Sjogren's syndrome clinic attended on five occasions at 4-week intervals. They were randomized, having the device f...
journal_title:Oral diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1601-0825.2005.01161.x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in human immunodeficiency virus (HIV) positive women from the Women's Interagency HIV Study (WIHS). DESIGN:Longitudinal cohort study. SUBJECTS AND METHODS:A total of 668 HIV positive women from the WIHS cohort...
journal_title:Oral diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1601-0825.2008.01456.x
更新日期:2009-01-01 00:00:00
abstract::The combination of Moebius and Poland anomalies is rarely described in the literature. While some authors believe this association is an independent syndrome, others think that Poland, Moebius and Poland-Moebius syndromes are variations of the same condition. We report a case of Poland-Moebius syndrome in a 6-year-old...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2004.01045.x
更新日期:2004-11-01 00:00:00
abstract::The basic treatment of chronic periodontitis is a mechanical debridement of periodontal pockets by scaling and root planing (S/RP) in combination with efficient plaque control. Locally delivered antiseptics (LDA) have been proposed to practitioners and, while subgingival irrigation of antiseptics is still used in clin...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1034/j.1601-0825.9.s1.8.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To assess the effects of periodontitis on renal interstitial fibrosis in a mouse model. MATERIALS AND METHODS:Thirty C57BL/6 male mice were divided into control, periodontitis (PD), unilateral ureteral ligation (UUO) and PD+UUO groups. Unilateral ureteral ligation was performed 6 days after periodontitis. A...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13764
更新日期:2020-12-31 00:00:00
abstract::Periodontal tissues are constantly exposed to microbial stimuli. The equilibrium between microbes and host defense system helps maintain the homeostasis in the periodontal microenvironment. Growth of pathogenic bacteria in dental biofilms may induce proinflammatory cytokine production to recruit sentinel cells, mainly...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12722
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine the relationship between active osteoclasts, as defined by positive nuclear NFATc1 signals, and the clinical behaviors of oral giant cell granulomas. MATERIALS AND METHODS:NFATc1 immunohistochemical and TRAP-Cbfa1 double immunofluorescence stainings were performed on 9 ca...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13022
更新日期:2019-04-01 00:00:00
abstract::The deep mycoses are uncommon infections, usually acquired from the inhalation or ingestion of fungal spores, sometimes from the soil in areas of endemicity, such as in the Americas and south-east Asia, or from decaying vegetable matter. They are also seen in immunocompromised persons and, increasingly, in HIV-infecte...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.1997.tb00361.x
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the oral functionality and the oral sensorimotor alterations are associated with oropharyngeal dysphagia in community-dwelling older persons and long-term care older residents. METHODS:An exploratory study with 265 independent older persons of the southern state of Brazil. The diagnosis o...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12809
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To detail a scoping review on the global and regional relative frequencies of oral mucosal disorders in the children based on both clinical studies and those reported from biopsy records. MATERIALS AND METHODS:A literature search was completed from 1 January 1990 to 31 December 2018 using PubMed and EMBASE. ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13112
更新日期:2019-06-01 00:00:00
abstract::With a history of over 2000 years, traditional Chinese medicine (TCM) evolves into a unique system of diagnosing and treating illnesses. It is a challenge to convey the fundamentals of this traditional medicine to our Western colleagues because of the differences in language, philosophy and concept of diagnosis and tr...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2010.01706.x
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To explore the type and prevalence of oral mucosal lesions among adults with primary HIV infection (PHI) compared with HIV-negative adults at high risk for HIV disease, and in relation to HIV viral load. METHODS:We conducted standardized oral examinations to identify specific oral mucosal lesions among adult...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01407.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:A multicentre collaborative study by the London HIV and Dentistry Group failed to associate the presence of erythematous candidiasis (EC) with advanced HIV disease. Data from a study of the periodontal health of homosexual men attending a genito-urinary medicine clinic presented an opportunity to investigate...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1997.tb00339.x
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to establish a possible association between the degree of differentiation of squamous cell carcinomas (SCC) derived from rat oral tissues treated in vivo with carcinogen 4NQO, and the expression of TGF-beta on epithelial cells and the distribution of extracellular matrix proteins (la...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1996.tb00198.x
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:This study was designed to establish a rat model of a critical size alveolar bone defect. MATERIALS AND METHODS:Standardized buccal or mesiobuccal alveolar bone defects were made around the right first mandibular molar of 12-week-old rats, and the left was used as a control. Alveolar bone healing was examine...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01522.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Oral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease-specific biomarkers in saliva is an easy, quick, and non-invasive approach for molecular diagnosis. This study was design...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12374
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP). METHODS:Patients with RAS (n = 15) and LP (n = 18) an...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13420
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To investigate the sex differences in clinical features, including salivary flow rate, psychological distress and hypothalamic-pituitary-adrenal axis response and their inter-relationships in patients with burning mouth syndrome. SUBJECTS AND METHODS:Eighteen men and 37 postmenopausal women with burning mout...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13195
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To explore the potential of detecting the level of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1-alpha (IL-1-alpha), IL-6, and IL-8 in whole unstimulated saliva (WUS) in monitoring the therapeutic effects of topical dexamethasone on these salivary cytokines in subjects with...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2005.01165.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:Bisphosphonates are widely used to treat bone diseases such as osteoporosis. However, they may cause osteonecrosis of the jaw. Here, we investigated whether in vivo exposure to bisphosphonates has a different effect on long bone and jaw osteoclasts, and on the turnover of these different bones. MATERIALS AN...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12587
更新日期:2017-01-01 00:00:00